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Yeast-based screening platform for rapid identification of GPCR agonists
This invention is a yeast-based screening platform that uses tethered peptide libraries to identify human GPCR agonists quickly and cost-effectively, yielding receptor-specific ligands and valuable insights into GPCR drug discovery.
Background
The field of receptor pharmacology and drug discovery continues to seek improved methods for reliably identifying...
Published: 3/4/2025
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Inventor(s): Andrew Ellington, Colleen Mulvihill, Jimmy Gollihar, Elizabeth Gardner, Edward Marcotte
Keywords(s):
Category(s): Life sciences > Therapeutics > Drug screening, Life sciences > Therapeutics > Drug discovery
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Chemical language model for identifying functionally similar molecules across structural variants
A chemical language model identifies functionally similar molecules to a query by using SMILES strings and different canonicalization algorithms. This method finds structurally distinct but functionally analogous molecules, aiding drug discovery by focusing on functional rather than structural similarities.
Background
Chemical similarity searches...
Published: 10/21/2024
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Inventor(s): Andrew Ellington, Clayton Kosonocky, Aaron Feller
Keywords(s):
Category(s): Life sciences > Medical technology > TechBio (software innovation in healthcare)
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SmartScreen: enhancing receptor interactions with RCPR technology
The technology uses Receptor Compartmentalized Partnered Replication (RCPR) to identify optimal interactions between receptors or pathways and their effector molecules by selectively amplifying genes that produce a thermostable polymerase during thermal cycling in emulsified libraries.
Background
The technology involves the identification and evolution...
Published: 9/10/2024
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Inventor(s): Andrew Ellington, Jimmy Gollihar, Elizabeth Gardner, Katie Kao
Keywords(s):
Category(s): Life sciences > Research tools > Tool/assay/screening platform
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Unbiased material identification and characterization using proximity ligation assay technology
The technology describes a method for characterizing known or unknown materials using libraries of probes that bind to them. These probes, which can be oligonucleotides or peptides linked to polynucleotide barcodes, are analyzed via sequencing to identify material-specific patterns, enabling the detection and identification of known and unknown materials.
Background
Characterizing...
Published: 8/2/2024
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Inventor(s): Andrew Ellington, Sanchita Bhadra, Zachary Wentzell
Keywords(s):
Category(s): Life sciences > Research tools > Tool/assay/screening platform
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Engineered RNA polymerases and capping enzymes for the expression of 7‑methylguanylate capped RNA
Background
Dr. Andrew Ellington and his team have identified and engineered a novel group II intron reverse transcriptase, RT-12. Dr. Ellington is a Professor in Molecular Biosciences, the Nancy Lee and Perry R. Bass Regents Chair in Molecular Biology, and holds the Wilson M. and Kathryn Fraser Research Professorship in Biochemistry at UT Austin. His...
Published: 2/7/2025
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Inventor(s): Andrew Ellington, Shaunak Kar, Elizabeth Gardner, Jimmy Gollihar, Raghav Shroff
Keywords(s):
Category(s): Life sciences > Research tools > Reagent, Life sciences > Therapeutics > Gene therapy
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Low-cost rapid diagnosis of viral diseases
Background/problem
Detection of infectious diseases relies on amplification techniques of genetic material such as RNA or DNA. State-of-the-art amplification techniques include RT-PCR and RT-LAMP, both of which use a reverse transcriptase (RT) to amplify RNA. Usually, an RNA strand is reverse transcribed into complementary DNA (cDNA), which is...
Published: 3/10/2025
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Inventor(s): Andrew Ellington, Inyup Paik, Sanchita Bhadra, Shaunak Kar
Keywords(s):
Category(s): Life sciences > Research tools > Reagent
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Innovative modularization of One Pot PURE system for commercial unnatural amino acid incorporation
Background
The integration of non-canonical amino acids into proteins holds immense promise for various industries, from biomedicine to biotechnology. However, traditional methods face challenges like high costs and batch variability. The One Pot PURE system, a streamlined version of cell-free protein synthesis, addresses these issues, offering precise...
Published: 5/8/2024
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Inventor(s): Andrew Ellington, Phuoc (Jaydin) Ngo, Satoshi Ishida, Bianca Busogi, Maximiliano Ledesma
Keywords(s):
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Research tools > Reagent
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Thermostable reverse transcriptase based on a thermostable DNA polymerase
Background
Reverse transcriptase enzymes are pivotal in molecular biology for transcribing RNA into DNA, facilitating studies from gene expression analysis to viral detection. The reliability and efficiency of reverse transcription are crucial for accurate cDNA formation, a foundational step necessary for subsequent applications such as cloning and...
Published: 3/10/2025
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Inventor(s): Andrew Ellington, Jared Ellefson, Jimmy Gollihar
Keywords(s):
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Research tools > Reagent
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Revolutionizing plastic recycling: FAST-PETase enzyme variant
Background
Plastic waste is a pressing ecological challenge, with a staggering 8.3 billion metric tons produced, of which 6 billion tons become waste. Traditional methods of plastic degradation, such as chemical processes, are costly and generate harmful byproducts. Enzymatic degradation presents a sustainable alternative, with poly (ethylene terephthalate)...
Published: 3/4/2024
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Inventor(s): Hal Alper, Andrew Ellington, Daniel Diaz, Hongyuan Lu
Keywords(s):
Category(s): Life sciences > Agriculture, Life sciences > Metabolic engineering
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Plastic-degrading enzymes
Able to break down PET plastics in as little as 24 hours
Overview
Plastic waste poses an ecological challenge. There have been 8.3 billion metric tons of plastics produced—6 billion tons are waste. What do we do with this waste?
The long-term, sustainable solution is to find effective ways to break down the plastic into smaller parts and then...
Published: 2/28/2024
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Inventor(s): Hal Alper, Andrew Ellington, Hongyuan Lu
Keywords(s):
Category(s): Life sciences > Agriculture, Life sciences > Research tools > Reagent, Physical sciences > Energy > Renewable, green, or transitional energy
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