Search Results - andrew+ellington

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Machine-learning guided engineering of T7 RNA polymerase and mRNA capping enzyme for enhanced gene expression in eukaryotic systems
This technology uses machine learning to engineer improved enzymes that dramatically boost gene expression in eukaryotic cells, enabling more efficient production of mRNA, proteins, and therapeutics for research, industrial, and medical applications. Background The field of eukaryotic gene expression is foundational to biotechnology, synthetic biology,...
Published: 7/10/2026   |   Updated: 7/10/2026   |   Inventor(s): Andrew Ellington, Daniel Diaz, Seunggyun Woo, Wantae Kim, Kaci Erwin, Ilya Finkelstein, Chien-Hui Ma, Do-Wook Kim
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent, Life sciences > Therapeutics > Gene therapy
Biological Expression Platform for Producing and Engineering Electrically Conductive Protein Nanowires and Bioelectronic Materials
This technology uses engineered Shewanella oneidensis bacteria to rapidly produce highly conductive protein nanowires for sustainable energy, bioelectronics, and sensor applications, offering a scalable, cost-effective, and eco-friendly alternative to synthetic conductive materials. Background The field of bioelectronics and sustainable energy harvesting...
Published: 8/4/2026   |   Updated: 7/10/2026   |   Inventor(s): Andrew Ellington, Eric Szmuc, Benjamin Keitz, David Walker, Marcel Reed
Keywords(s):  
Category(s): Life sciences > Biomaterials, Physical sciences > Energy > Renewable, green, or transitional energy
Self-Assembling Nanolattices with Superior Tensile Strength That are Scalable and Free of Cracks
Elimination of cracks in self-assembly using a wet template and positively charged particles produces relatively large-area nanolattices with enhanced tensile strength. Problem: Nanolattice fabrication is currently dominated by 3D-printing that employs 2-photon polymerization. However, structures made in this fashion feature imperfections which lead...
Published: 6/25/2026   |   Updated: 6/25/2026   |   Inventor(s): James Pikul, Zhimin Jiang, David Issadore, Andrew Lin
Keywords(s): Nanotechnology, Optics & Photonics 
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Energy
Genetically engineered cell surface biosensors for high-throughput detection, screening, and recovery of rare earth elements
This technology uses genetically engineered yeast cells displaying fluorescent sensors to detect and recover rare earth elements from solutions, enabling rapid, specific, and scalable metal screening and extraction using fluorescence signals and high-throughput sorting. Background Rare earth elements (REEs) are a group of 17 chemically similar metals...
Published: 3/30/2026   |   Updated: 3/30/2026   |   Inventor(s): Manish Kumar, Marcus Benyamin, Steven Zilko, Andrew Ellington, Benjamin Keitz, Randall Hughes
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Therapeutics > Synthetic biology
Allosteric transcription factors as peptide sensors
Modular intracellular peptide sensors for programmable gene control Background Synthetic biology increasingly relies on precise gene regulation systems that can sense and respond to specific molecular signals inside living cells. Peptides and peptide-tagged proteins are especially important targets because they govern communication, signaling, and...
Published: 2/17/2026   |   Updated: 2/17/2026   |   Inventor(s): Andrew Ellington, Brice Hendrickson, Alia Clark-ElSayed, Dylan Brown, Julius Lucks
Keywords(s):  
Category(s): Life sciences > Metabolic engineering, Life sciences > Research tools > Tool/assay/screening platform
Supercharged fluorescent protein biosensors for real-time lanthanide monitoring
Background Rare earth elements—particularly lanthanides like terbium, thulium, and dysprosium—are essential to technologies underpinning renewable energy, electrified transportation, high-performance magnets, and medical imaging. As demand accelerates, sustainable extraction and recycling processes require precise monitoring of these valuable...
Published: 5/27/2026   |   Updated: 1/30/2026   |   Inventor(s): Andrew Ellington, Kevin Huang, David Walker
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Physical sciences > Environmental & sustainable solutions
Sequence-defined oligourethane probe libraries for high-resolution surface characterization
Background Understanding the chemical landscape of material and biological surfaces at the molecular level is critical for advancing applications in materials science, biotechnology, and environmental monitoring. Surface-bound functional groups govern key interactions relevant to contamination detection, catalyst performance, biosensing, and drug discovery....
Published: 1/30/2026   |   Updated: 1/30/2026   |   Inventor(s): Eric Anslyn, Andrew Ellington, Hazel Fargher, Heather Graham, Hannah McLain
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Transgenic Mouse Model for Marfan Syndrome Research
Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...
Published: 12/23/2025   |   Updated: 12/23/2025   |   Inventor(s): Li Li, Shichao Wu, Jiawei Zhao
Keywords(s):  
Category(s): Technology Category > Research tools, Technology Category > Animal models, Technology Category > Biology, Technology Category > Diagnostic
Engineered orthogonal elongation factor for SECIS-independent noncanonical amino acid incorporation
Background Selenocysteine (Sec), the 21st amino acid, offers unique redox and catalytic properties that are valuable for biocatalysis, therapeutic protein engineering, and redox biology. However, its use in synthetic biology and protein engineering has been restricted by the complexity of its natural biosynthetic machinery. Sec incorporation typically...
Published: 1/13/2026   |   Updated: 12/4/2025   |   Inventor(s): Andrew Ellington, Satoshi Ishida
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology, Life sciences > Metabolic engineering
Engineered E. coli platform for high-yield selenoprotein expression
Background Selenoproteins, which incorporate the amino acid selenocysteine (Sec), are prized for their unique redox properties and catalytic capabilities in therapeutic antibodies, industrial enzymes, and diagnostic reagents. However, these proteins remain difficult and costly to produce in large quantities. Traditional chemical synthesis is labor-intensive...
Published: 1/13/2026   |   Updated: 12/3/2025   |   Inventor(s): Andrew Ellington, Ross Thyer
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Therapeutics > Synthetic biology
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