Search Results - andrew+ellington

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Engineered orthogonal elongation factor for SECIS-independent noncanonical amino acid incorporation
Background Selenocysteine (Sec), the 21st amino acid, offers unique redox and catalytic properties that are valuable for biocatalysis, therapeutic protein engineering, and redox biology. However, its use in synthetic biology and protein engineering has been restricted by the complexity of its natural biosynthetic machinery. Sec incorporation typically...
Published: 12/4/2025   |   Inventor(s): Andrew Ellington, Satoshi Ishida
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology, Life sciences > Metabolic engineering
Engineered E. coli platform for high-yield selenoprotein expression
Background Selenoproteins, which incorporate the amino acid selenocysteine (Sec), are prized for their unique redox properties and catalytic capabilities in therapeutic antibodies, industrial enzymes, and diagnostic reagents. However, these proteins remain difficult and costly to produce in large quantities. Traditional chemical synthesis is labor-intensive...
Published: 12/3/2025   |   Inventor(s): Andrew Ellington, Ross Thyer
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Therapeutics > Synthetic biology
Ultrafast Thin-Film Vapor Deposition Technique
Invention Description The demand for advanced thin-film deposition techniques has grown substantially in recent years, driven by the development of next-generation electronic, optoelectronic, and energy devices. Traditional deposition methods, such as chemical vapor deposition, molecular beam epitaxy, and physical vapor deposition, have well-established...
Published: 11/18/2025   |   Inventor(s): Feng Yan, Lin Li
Keywords(s):  
Category(s): Semiconductors, Materials & Processes, Microelectronics, Physical Science, Semiconductor Devices, Manufacturing/Construction/Mechanical
Engineered bacterial platform for in situ mRNA delivery to mammalian cells
Background Genetic medicine depends on the ability to deliver messenger RNA (mRNA) into mammalian cells to enable therapeutic protein expression, correct genetic defects, or produce antigens for vaccines. But current delivery systems face critical barriers that limit their clinical utility. DNA plasmid-based approaches often show poor transfection...
Published: 11/25/2025   |   Inventor(s): Bryan Davies, Christopher Sullivan, Andrew Ellington
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Research tools > Tool/assay/screening platform
Universal chimeric primer system for real-time, sequencing-compatible lamp assays
Background Loop-mediated isothermal amplification (LAMP) has become a cornerstone of nucleic acid detection for clinical diagnostics, environmental monitoring, and point-of-care testing, offering rapid amplification with minimal equipment needs. Operating at a constant temperature, LAMP avoids the complexities of thermal cycling required by PCR, enabling...
Published: 11/25/2025   |   Inventor(s): Andrew Ellington, Sanchita Bhadra
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent
SmartScreen: enhancing receptor interactions with RCPR technology
The technology uses Receptor Compartmentalized Partnered Replication (RCPR) to identify optimal interactions between receptors or pathways and their effector molecules by selectively amplifying genes that produce a thermostable polymerase during thermal cycling in emulsified libraries. Background The technology involves the identification and evolution...
Published: 11/25/2025   |   Inventor(s): Andrew Ellington, Jimmy Gollihar, Elizabeth Gardner, Katie Kao
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Unbiased material identification and characterization using proximity ligation assay technology
The technology describes a method for characterizing known or unknown materials using libraries of probes that bind to them. These probes, which can be oligonucleotides or peptides linked to polynucleotide barcodes, are analyzed via sequencing to identify material-specific patterns, enabling the detection and identification of known and unknown materials. Background Characterizing...
Published: 11/25/2025   |   Inventor(s): Andrew Ellington, Sanchita Bhadra, Zachary Wentzell
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Engineered RNA polymerases and capping enzymes for the expression of 7‑methylguanylate capped RNA
Background Dr. Andrew Ellington and his team have identified and engineered a novel group II intron reverse transcriptase, RT-12. Dr. Ellington is a Professor in Molecular Biosciences, the Nancy Lee and Perry R. Bass Regents Chair in Molecular Biology, and holds the Wilson M. and Kathryn Fraser Research Professorship in Biochemistry at UT Austin. His...
Published: 11/25/2025   |   Inventor(s): Andrew Ellington, Shaunak Kar, Elizabeth Gardner, Jimmy Gollihar, Raghav Shroff
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent, Life sciences > Therapeutics > Gene therapy
Low-cost rapid diagnosis of viral diseases
Background/problem Detection of infectious diseases relies on amplification techniques of genetic material such as RNA or DNA. State-of-the-art amplification techniques include RT-PCR and RT-LAMP, both of which use a reverse transcriptase (RT) to amplify RNA. Usually, an RNA strand is reverse transcribed into comple­mentary DNA (cDNA), which is...
Published: 11/25/2025   |   Inventor(s): Andrew Ellington, Inyup Paik, Sanchita Bhadra, Shaunak Kar
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent
Innovative modularization of One Pot PURE system for commercial unnatural amino acid incorporation
Background The integration of non-canonical amino acids into proteins holds immense promise for various industries, from biomedicine to biotechnology. However, traditional methods face challenges like high costs and batch variability. The One Pot PURE system, a streamlined version of cell-free protein synthesis, addresses these issues, offering precise...
Published: 11/25/2025   |   Inventor(s): Andrew Ellington, Phuoc Ngo, Satoshi Ishida, Bianca Busogi, Maximiliano Ledesma
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Research tools > Reagent
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