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Search Results - chunyu+wang
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Compounds and methods to target transmembrane domain of membrane proteins (e.g., APPTM) to inhibit intramembrane proteolysis
RPI ID: 2019-075-401, 2019-076-601 Innovation Summary: A substrate-specific inhibitor is proposed to block γ-secretase cleavage of amyloid precursor protein (APP), aiming to reduce amyloid-β (Aβ) production without affecting other physiological substrates. Unlike broad-spectrum γ-secretase inhibitors that target presenilin directly,...
Published: 3/10/2026
|
Inventor(s):
Chunyu Wang
Keywords(s):
Alzheimer's disease
,
amyloid
,
amyloid precursor protein
,
anti-Abeta
,
C99
,
gamma-secretase
,
intramembrane proteolysis
,
Notch
,
transmembrane domain of APP
Category(s):
Biotechnology and the Life Sciences
Alpha Assay to Screen for Inhibitor Protein-Glycan Interactions in Neurodegeneration
RPI ID: 2024-030-201 Innovation Summary: This technology introduces a bead-based assay platform designed to screen for inhibitors of protein-glycan interactions implicated in neurodegenerative diseases. The assay utilizes functionalized beads to capture glycan-binding proteins and assess their interaction dynamics in the presence of candidate inhibitors....
Published: 3/10/2026
|
Inventor(s):
Chunyu Wang
,
Shannon Faris
Keywords(s):
AlphaScreen
,
Alzheimer's disease
,
Drug Discovery
,
heparan sulfate proteoglycan (HSPG)
,
Heparin
,
tau
,
tauopathies
Category(s):
Biotechnology and the Life Sciences
Natural Compound for Bitter Taste Masking
Reduces the Bitter Taste of Nutraceuticals and Medications, Improving Their Palatability This naturally occurring anti-bittering compound reduces the bitter taste of certain foods and pharmaceuticals, improving their palatability and consumption. Bitterness is one of the five basic taste modalities. People have strong aversions to bitterness, particularly...
Published: 1/20/2026
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Inventor(s):
Yu Wang
,
Jinpyo An
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Nutraceutical
,
Technology Classifications > Others > Others
Lithium selective organogels
Background Lithium (Li) is a highly reactive alkali metal with excellent heat and electrical conductivity properties, making it useful for a variety of industrial applications. Because of Li’s high reactivity, pure elemental Li is not found in nature but is present as a constituent of salts or other compounds found in brines, mineral ores, clays,...
Published: 1/13/2026
|
Inventor(s):
Jonathan Sessler
,
Zachariah Page
,
Hu Wang
Keywords(s):
Category(s):
Physical sciences > Materials
,
Life sciences > Research tools > Tool/assay/screening platform
,
Physical sciences > Energy > Battery or electrochemical
,
Physical sciences > Energy > Renewable, green, or transitional energy
AAV Vectors for Improved CNS Targeting
Targets Neuronal Cells to Develop Gene Therapies and Treat Neurological Diseases These engineered AAV vectors are designed to target neuronal cell types to aid in the development of gene therapies, which can treat a variety of neurological diseases. In 2020, the market for CNS targeting technologies was worth $6 billion and is expected to reach $46.5...
Published: 1/20/2026
|
Inventor(s):
Robert McKenna
,
Mario Mietzsch
,
Judit Penzes
,
Mavis Agbandje-McKenna
,
Chun Yu
,
Alberto Ybargollin
,
Alana Johnson
,
Jane Hsi
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Therapeutics
Silk Wrinkles: Tuning Structural Protein Coformation for Dynamic, Responsive, Multifunctional Micropatterns
PROBLEM Protein micropatterning and nanopatterning have long provided sophisticated strategies for a wide range of applications including biointerfaces, tissue engineering, optics/photonics, and bioelectronics. In recent years, various micro- and nanofabrication technologies have been utilized to transform a water-based suspension of silk protein into...
Published: 1/23/2025
|
Inventor(s):
Fiorenzo Omenetto
,
Yu Wang
Keywords(s):
Category(s):
Biomaterials
On-Chip Polarization Detection and Polarimetric Imaging
Background Recent innovations have allowed us to manipulate light for uses in a variety of applications such as information processing and quantum computing. More specifically, polarization of light has become an attractive method for communicating optical data, demonstrating better sensitivity, signal in free space, and capacity than conventional...
Published: 2/26/2026
|
Inventor(s):
Yu Yao
,
Chao Wang
,
Chu Wang
,
Jing Bai
,
Ali Basiri
,
Xiahui Chen
Keywords(s):
Materials and Electronics
,
Medical Devices and Imaging
,
Networks, IT, Software and Communication
Category(s):
Physical Science
,
Imaging
Rapid and High Yield Reduction of CO2 to Commercially Valuable Multi Carbon Products
Rapid and High Yield Reduction of CO2 to Commercially Valuable Multi Carbon Products Princeton Docket # 18-3372-1 The laboratory of Prof. Andrew Bocarsly has created a collection of alloy electrodes capable of reducing CO2 to high value multi-carbon products in a fast, efficient, and high yield manner that is industrially attractive for CO2...
Published: 2/4/2025
|
Inventor(s):
Aubrey Paris
,
Sonja Francis
,
An Chu
,
Andrew Bocarsly
Keywords(s):
Category(s):
Chemistry
Disturbed Self-assembly: Growing Block Copolymer Nanosheet (BCNS) Densely and Naturally
AbstractNanosheet plays an important role in the development of clinical therapeutics and diagnostics e.g., bioimaging/sensing, drug delivery systems and tissue engineering. As one of the most important approaches to preparing nanomaterials, self-assembly is able to give rise to various nanostructures from zero-dimension nanoparticles to three-dimension...
Published: 10/8/2024
|
Inventor(s):
Yu Wang
,
Weihong Zhong
Keywords(s):
Category(s):
Technologies > Next Generation Materials & Technology > Nanotechnology
Functionalized Porous Polymer Nanocomposites via Introducing Functional Components into Emulsion Systems
AbstractFunctional porous polymer films are of great interest to academia as well as industry for a variety of applications, such as gas separation, water purification and sensors. A porous structure can not only reduce the density of the material, but can also remarkably increase the surface/interface area, which can be used for various functionalizations....
Published: 10/8/2024
|
Inventor(s):
Yu Wang
,
Weihong Zhong
,
Bin Li
Keywords(s):
Category(s):
Technologies > Energy & Environment > Clean Tech
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