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Compounds and methods to target transmembrane domain of membrane proteins (e.g., APPTM) to inhibit intramembrane proteolysis
RPI ID: 2019-075-401, 2019-076-601 Innovation Summary: A substrate-specific inhibitor is proposed to block γ-secretase cleavage of amyloid precursor protein (APP), aiming to reduce amyloid-β (Aβ) production without affecting other physiological substrates. Unlike broad-spectrum γ-secretase inhibitors that target presenilin directly,...
Published: 3/10/2026   |   Inventor(s): Chunyu Wang
Keywords(s): Alzheimer's disease, amyloid, amyloid precursor protein, anti-Abeta, C99, gamma-secretase, intramembrane proteolysis, Notch, transmembrane domain of APP
Category(s): Biotechnology and the Life Sciences