Search Results - amyloid+precursor+protein

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Compounds and methods to target transmembrane domain of membrane proteins (e.g., APPTM) to inhibit intramembrane proteolysis
RPI ID: 2019-075-401, 2019-076-601 Innovation Summary: A substrate-specific inhibitor is proposed to block γ-secretase cleavage of amyloid precursor protein (APP), aiming to reduce amyloid-β (Aβ) production without affecting other physiological substrates. Unlike broad-spectrum γ-secretase inhibitors that target presenilin directly,...
Published: 3/10/2026   |   Updated: 3/10/2026   |   Inventor(s): Chunyu Wang
Keywords(s): Alzheimer's disease, amyloid, amyloid precursor protein, anti-Abeta, C99, gamma-secretase, intramembrane proteolysis, Notch, transmembrane domain of APP
Category(s): Biotechnology and the Life Sciences
Multidimensional MRI Signature for Specific Detection of Traumatic Brain Injury In Vivo
Summary: The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) seeks research co-development partners and/or licensees for the development of multidimensional MRI-based methods. Description of Technology: Traumatic brain injury (TBI) represents a major medical, social and economic concern worldwide due to significant...
Published: 4/23/2026   |   Updated: 8/2/2023   |   Inventor(s): Dan Benjamini, Peter Basser, Diego Iacono
Keywords(s): Amyloid Precursor Protein, Be, DAI, Diffuse Axonal Injury, Eunice Kennedy Shriver National Institute of Child Health an, Magnetic Resonance Imaging, MRI, MULTIDIMENSIONAL, NICHD, TAI, TBI, Traumatic Axonal Injury, Traumatic Brain Injury
Category(s): TherapeuticArea > Neurology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics