Search Results - heparin

5 Results Sort By:
Nasal spray using PPS and MPS for COVID-19 prevention and treatment
RPI ID: 2021-049-201 Innovation Summary: A nasal spray formulation combines pentosan polysulfate and mucopolysaccharide polysulfate to prevent and treat COVID-19. The compounds act as viral entry inhibitors by blocking spike protein binding to host cells. The spray is designed for prophylactic and therapeutic use, with potential for broad-spectrum...
Published: 3/10/2026   |   Inventor(s): Fuming Zhang, Jawed Fareed, Walter Jeske, Robert Linhardt
Keywords(s): antiviral drug, COVID19, Heparin, mucopolysachharide polysulfate, Nasal spray, Pentosan polysulfate, prevention
Category(s): Biotechnology and the Life Sciences
Heparin and Heparin Analogs with Exceptional Binding Affinity to SARS-CoV-2 Spike Protein as Potential Therapeutics
RPI ID: 2020-082-401 / 2020-082-601 / 2020-082-602 Innovation Summary: Compositions containing sulfated polysaccharides such as pentosan polysulfate and mucopolysaccharide polysulfate are designed to inhibit SARS-CoV-2 by blocking viral entry and replication. These formulations are intended for mucosal delivery via nasal spray or aerosol, enabling...
Published: 3/10/2026   |   Inventor(s): So Young Kim, Weihua Jin, Jonathan Dordick, Fuming Zhang, Seok-Joon Kwon, Paul Kwon, Keith Fraser, Robert Linhardt
Keywords(s): Heparin, Non-Anticoagulant Heparin, SARS-CoV-2 Spike Protein, TriS HS
Category(s): Biotechnology and the Life Sciences
Alpha Assay to Screen for Inhibitor Protein-Glycan Interactions in Neurodegeneration
RPI ID: 2024-030-201 Innovation Summary: This technology introduces a bead-based assay platform designed to screen for inhibitors of protein-glycan interactions implicated in neurodegenerative diseases. The assay utilizes functionalized beads to capture glycan-binding proteins and assess their interaction dynamics in the presence of candidate inhibitors....
Published: 3/10/2026   |   Inventor(s): Chunyu Wang, Shannon Faris
Keywords(s): AlphaScreen, Alzheimer's disease, Drug Discovery, heparan sulfate proteoglycan (HSPG), Heparin, tau, tauopathies
Category(s): Biotechnology and the Life Sciences
MPS and PPS and other sulfated GAG analogs to treat/prevent Monkeypox
RPI ID: 2023-007-601 Innovation Summary: This technology describes therapeutic systems and methods using sulfated glycosaminoglycans (GAGs) and GAG analogs to treat or prevent monkeypox virus (Mpox) infections. The compounds interfere with viral attachment and entry mechanisms, reducing infectivity. The approach is designed for topical or systemic...
Published: 3/10/2026   |   Inventor(s): Robert Linhardt, Jonathan Dordick, Deling Shi, Fuming Zhang
Keywords(s): A29, Chondroitin sulfate, Dermatan sulfate, Heparin, Monkeypox virus
Category(s): Biotechnology and the Life Sciences
Improved Culture Medium for Stem Cell Maintenance and Differentiation
A novel low protein culture medium with defined chemical components that allows pluripotent stem cell maintenance and differentiation is disclosed. The present technology also provides for production of high quality cardiac cells from human embryonic and induced pluripotent stem cells in chemically defined medium conditions. Human pluripotent stem...
Published: 10/28/2024   |   Inventor(s): Yongshun Lin, Guokai Chen
Keywords(s): AC5XXX, ACXXXX, ADDITIVES, AXXXXX, Cell, Chemically, CM-dextran, CULTURE, DEFINED, DIFFERENTIATION, GLYCOGEN, HEPARIN, Human, IMPROVING, Lipid, Maintenance, Medium, Pluripotent, RXXXXX, Stem, Trehalose
Category(s): Collaboration Sought > Collaboration, Application > Research Materials