Search Results - mavis+agbandje-mckenna

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Modified AAV5 Vectors for Enhanced Transduction and Reduced Antibody Neutralization
Scientists at the NIH disclosed a mutated adeno-associated virus (AAV) serotype 5 by modifying sialic acid binding regions which mediate viral entry into host cells. Preliminary results from animal studies suggest that this modification can increase transduction by 3-4 folds in salivary glands and muscles, and can significantly decrease the potential...
Published: 10/28/2024   |   Inventor(s): Sandra Afione-Wainer, Mavis Agbandje-Mckenna, Sujata Halder, John (Jay) Chiorini
Keywords(s): AAV5, ANTIBODY, ENGINEERED, Enhanced, GENETICALLY, Listed LPM Reichman as of 4/15/2015, Neutralization, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, REDUCED, transduction, VAXXXX, VCXXXX, vectors, VFXXXX, VGXXXX, WJXXXX, XEXXXX, YAXXXX, YCXXXX
Category(s): TherapeuticArea > Immunology, TherapeuticArea > Geriatrics, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology, Application > Therapeutics
AAV Vectors for Improved CNS Targeting
Targets Neuronal Cells to Develop Gene Therapies and Treat Neurological Diseases These engineered AAV vectors are designed to target neuronal cell types to aid in the development of gene therapies, which can treat a variety of neurological diseases. In 2020, the market for CNS targeting technologies was worth $6 billion and is expected to reach $46.5...
Published: 7/14/2023   |   Inventor(s): Robert McKenna, Mario Mietzsch, Judit Penzes, Mavis Agbandje-McKenna, Chun Yu, Alberto Ybargollin, Alana Johnson, Jane Hsi
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
AAV Gene Therapy Capsid Variants That Evade Neutralizing Antibodies
Enable Patients With Anti-Capsid Antibodies for AAV8 or AAVrh.10 to Participate in Clinical Trials to Undergo Gene Therapy with AAV These adeno-associate vector capsid variants offer antibody-escaping abilities that will enable patients with antibodies against an AAV serotype to receive therapy or participate in clinical trials anyway. Due to the high...
Published: 9/15/2021   |   Inventor(s): Mavis Agbandje-McKenna, Mario Mietzsch
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Gene Therapy, Technology Classifications > Human Health Care > Therapeutics
Panel of Monoclonal Antibodies for Characterization of AAV8 and AAV9 Capsids to Improve Therapeutic Efficacy of AAV Gene-Based Therapy
More Accurately Characterizes AAV8 and AAV9 Capsids for Development of Next Generation Vectors to Evade the Host's Immune Response This panel of antibodies allows better characterization of antigenic epitopes on AAV8 and AAV9 capsids with the goal of mitigating patient immune response to the existing AAV based gene therapy. Adeno-associated viral (AAV)...
Published: 6/27/2021   |   Inventor(s): Mavis Agbandje-McKenna, Kim Van Vliet, Yu-Shan Tseng
Keywords(s): AAV Vectors, Antibody, Antibody-based assay, dot blot, Elisa, Hybridoma
Category(s): Technology Classifications > Research Tools > Biological Materials
Synthetic AAV Capsid Library for Targeted Gene Therapy with Improved Treatment Efficacy
Capsid Library Allows for Gene Therapy Vectors to Target Specific Organs and Tissues This adeno-associated virus (AAV) capsid library allows for targeted gene therapy to specific organs and tissues. Gene therapy is a burgeoning market within the pharmaceutical industry, with a market value projected to reach $500 million by 2020. AAV derived vectors...
Published: 6/27/2021   |   Inventor(s): Sergei Zolotukhin, Mavis Agbandje-McKenna, Damien Marsic
Keywords(s): AAV Vectors, capsid library, combinatorial library, Gene Therapy, Targeted delivery
Category(s): Technology Classifications > Human Health Care > Drug Delivery, Technology Classifications > Human Health Care > Gene Therapy
Gene Transfer Vector for Treating HER2/neu-positive Breast Cancer Metastasis in Bone Marrow
More Effective Treatment Has Fewer Side Effects, Wider ApplicationsThis gene transfer vector helps locate and destroy malignant breast cancer cells that have spread to the bone marrow by delivering tumor-suppressing genes or cytotoxic drugs to wherever they are needed in the patient’s body. In about 25 percent of breast cancers, a protein called...
Published: 6/27/2021   |   Inventor(s): Mavis Agbandje-McKenna, Kirsten Weigel-Van Aken
Keywords(s): breast cancer metastases in the human bone ma, HER2/neu receptor, HER2/neu-targeting viral vector, human parvovirus B19
Category(s): Technology Classifications > Human Health Care > Therapeutics
Lens with Electronically Controlled Optical Properties
Executive SummaryThis MSU-developed device allows for electrical control of the optical properties in a liquid lens and other optic devices. Capable of altering light’s focal point, this technology lends itself into many applications such as displays, microscopes, telescopes, interferometers, and many more. Description of TechnologyBy controlling...
Published: 8/20/2022   |   Inventor(s): Gary Blanchard, Greg Swain, Romana Jarosova, Ke Ma
Keywords(s):  
Category(s): Advanced Materials, Chemicals, Devices, Photonics