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Artificial nitrogenase enzymes for ambient-condition, decentralized ammonia production
Background Ammonia synthesis is foundational to global agriculture and chemical manufacturing, providing the primary source of fixed nitrogen for fertilizers, polymers, and pharmaceuticals. Traditional ammonia production through the Haber-Bosch process, however, operates under extreme conditions—temperatures exceeding 400°C and pressures...
Published: 7/2/2025
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Inventor(s):
Yi Lu
,
Hirbod Heidari
,
Markus Ribbe
,
Yilin Hu
,
Chi Chung Lee
,
Evan Mirts
Keywords(s):
Category(s):
Life sciences > Therapeutics > Synthetic biology
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Life sciences > Metabolic engineering
Discovery of potent and selective D3 antagonist with alleviated hERG liability and optimized pharmacokinetic properties
One of the most challenging hurdles in creating safe and effective new medicines for many diseases is finding drugs that are effective without causing off-target cardiac issues, such as cardiac arrythmias. In collaboration with NIDA, scientists at NCATS have developed a series of novel and highly specific dopamine D3 receptor agonists and antagonists...
Published: 6/13/2025
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Inventor(s):
Khalida Shamim
,
Wenwei Huang
,
Wei Zheng
,
Catherine Chen
,
Xiuli Huang
,
Xin Hu
,
Xin Xu
,
Pranav Shah
,
Elias Padilha
,
Philip Sanderson
,
Amy Newman
Keywords(s):
Category(s):
Application > Therapeutics
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Collaboration Sought > Licensing
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Collaboration Sought > Materials Available
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TherapeuticArea > Neurology
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TherapeuticArea > Psychiatry/Mental Health
High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025
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Inventor(s):
Stephen Liggett
,
Donghwa Kim
,
Yu Chen
,
Jesper Madsen
,
Steven An
Keywords(s):
Pharmaceuticals
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Respiratory Diseases Treatment
Category(s):
Technology Classifications > Medical > Respiratory
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Technology Classifications > Medical > Therapeutics
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Technology Classifications > Medical > Pharmaceuticals
Automatic Detection and Quantification of Marine Macroalgae from Satellite Imagery
Advantages: Automates seaweed detection and quantification using satellite imagery Combines physics-based models and machine learning for accurate results Generates actionable seaweed maps at various spatial and temporal resolutions Applicable globally works on both Sargassum and Ulva blooms across different regions Summary: Massive seaweed...
Published: 6/10/2025
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Inventor(s):
Chuanmin Hu
,
Mengqiu Wang
Keywords(s):
Category(s):
Technology Classifications > Electronics > Electronics Laser
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Technology Classifications > Data/AI > D/AI Imaging
Piperlongumine-Based PROTAC As Potent Anticancer Agent With Reduced Toxicity
Uses Piperlongumine as an E3 Ligase Ligand to Facilitate the Degradation of Cancer-Associated Proteins of Interest This naturally occurring compound with anti-cancer properties has the potential to revolutionize cancer treatment by providing tailored therapies with reduced side effects. Cancer remains a significant health issue in the United States,...
Published: 5/30/2025
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Inventor(s):
Guangrong Zheng
,
Daohong Zhou
,
Dongwen Lyu
,
Yaxia Yuan
,
Xingui Liu
,
Yufeng Xiao
,
Wanyi Hu
,
Jing Pei
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Therapeutics
Enterovirus D68 capsid inhibitors as antivirals
Plaque assay results of Jun11-46-1 and Jun11-54-1 against EV-D68 US/MO/14-18947. Invention Summary: Enterovirus D68 (EV-D68) is an RNA virus that mainly affects children and results in moderate to severe respiratory illness, with the most extreme cases resulting in muscle weakness, paralysis, and death. Currently, there are no antivirals...
Published: 1/27/2025
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Inventor(s):
Jun Wang
,
Yanmei Hu
,
Kan Li
Keywords(s):
Antibacterial
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Small molecules
Category(s):
Technology Classifications > Healthcare & Life Sciences
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Technology Classifications > Infectious Disease
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Technology Classifications > Therapeutics
Small Molecule Direct Inhibitors of Keap1-Nrf2 Protein-Protein Interaction
Non-covalent direct inhibition of the Keap1-Nrf2 PPI resulting in upregulation of ARE-gene expression. Thus, increase ARE-controlled cytoprotective oxidative stress response enzymes in the development of therapeutic and preventive agents for a number of diseases and conditions. Invention Summary: The Keap1-Nrf2-ARE system could protect...
Published: 1/14/2025
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Inventor(s):
Longqin Hu
,
Ahmed Ali
Keywords(s):
Category(s):
Technology Classifications > Therapeutics
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Technology Classifications > Healthcare & Life Sciences
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Technology Classifications > Cancer
Fluorogenic bioconjugation of cyclopropanol-containing fluorophores for biological applications
Reference #: 1742 The University of South Carolina is offering licensing opportunities for Fluorogenic bioconjugation of cyclopropanol-containing fluorophores for biological applications. Background: Fluorophores have been used in various applications of cellular microbiology, most notably with the reporting functions associated with various biological...
Published: 6/30/2025
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Inventor(s):
Qian Wang
,
Shan Hu
Keywords(s):
Category(s):
Chemistry and Biochemistry
Random and Safe (RaS) Cache Architecture to Defeat Cache Timing Attacks
Random and Safe (RaS) Cache Architecture to Defeat Cache Timing Attacks Princeton Docket # 25-4192-1 Princeton University researchers have developed an innovative hardware solution known as Random and Safe (RaS) caches to address critical security vulnerabilities in modern computer systems. This technology significantly enhances security by effectively...
Published: 12/11/2024
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Inventor(s):
Ruby Lee
,
Guangyuan Hu
Keywords(s):
Category(s):
Mechanical/Electrical Engineering
Rare-Earth-Element Free Yellow Phosphors for White Light-Emitting Diodes
Yellow phosphor emits white light when excited with the 460 nm blue lighting. The blue LED (left half; top) when coated with dispersed yellow phosphor (right half; top) emits white light. Invention Summary: Despite their low energy consumption and higher efficiency, white light-emitting diodes made of blue chip coupled with yellow phosphor...
Published: 12/4/2024
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Inventor(s):
Jing Li
,
Zhichao Hu
,
Qihan Gong
Keywords(s):
Electronics
,
LEDs
Category(s):
Technology Classifications > Physical Sciences & Engineering
,
Technology Classifications > Polymers/Composites/Materials
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Technology Classifications > Electronics/Semiconductor
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