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Oxynitidine Derivatives Useful as Inhibitors of Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) for Treating Cancer

Summary: The National Cancer Institute (NCI) is actively seeking potential licensees and/or co-development research collaboration partners interested in advancing oxynitidine derivatives as novel inhibitors of topoisomerase IB (TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1) for cancer treatment. These TOPI and TDP1 inhibitors, when administered...

Published: 9/18/2024 | Inventor(s): Yves Pommier, Lin-kun An, Keli Agama, Evgeny Kiselev, Azhar Ravji

Keywords(s): Benzophenanthridine Derivatives, Benzophenanthridinone, Camptothecin, Dihydrobenzophenanthridine, IRINOTECAN, Oxynitidine, Pommier, Tdp1, TOP1, Topoisomerase 1B, Topotecan, Tyrosyl-DNA Phosphodiesterase 1

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics

Comprehensive and Individualized Menopause Care Delivery Protocol With Technological Decision Support Aid (Case No. 2024-193)

Summary: Researchers in the UCLA Department of Obstetrics and Gynecology have developed a new clinical decision support system for improved menopause care. Background: Each year, approximately 1.3 million women in the United States enter menopause. This is often accompanied by symptoms such as hot flashes, mood changes, and sleep issues. In addition,...

Published: 9/3/2024 | Inventor(s): Rajita Patil, Erica Oberman, Brittany Davis, Rhonda Voskuhl, Kathleen Van Dyk, Ravi Aysola, Louise Dixon De Silva, Karol Watson, Lua Jafari, Julie Bernthal, Rashmi Mullur, Albert Shieh, Elizabeth Ko, Katie Hu, Aashini Master, Kelly Mccann, Kelsey Collins, Katherine Unverferth, Tamara Grisales, Amy Rosenman, Andrea Rapkin

Keywords(s): clinical care methodology, clinical decision support, EHR, EHR integration, electronic health records (EHR), FemTech, femtech medical device, lab results analysis, medical bias reduction, Menopause, menopause management, patient questionnaire, period, personalized medicine, predictive analytics, specialist referral, women’s health

Category(s): Software & Algorithms, Software & Algorithms > Programs, Software & Algorithms > Digital Health, Software & Algorithms > Artificial Intelligence & Machine Learning, Medical Devices, Medical Devices > FemTech

New Drugs for the Prevention of Kidney Stones

In vivo efficacy study of an LH prodrug expressed as days CaOx crystals were detected in mouse urine/mouse/week Invention Summary: Hyperoxaluria is a condition characterized by excessive urinary excretion of oxalate. It can result from inherited genetic mutations, intestinal diseases, or a diet high in oxalate. This often leads to calcium...

Published: 8/15/2024 | Inventor(s): Longqin Hu, Yiling Wang

Keywords(s): Drug Discovery/Screening

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics

Bioinformatics-powered CRISPR-transposon systems for enhanced gene editing and horizontal gene transfer

CRISPR-associated transposons (CASTs) use nuclease-deficient CRISPR-Cas systems for RNA-guided gene insertion, enhancing the gene-editing toolkit by enabling precise DNA integration. Background CRISPR-associated transposons (CASTs) represent a significant advancement in gene-editing technology, originating from the fusion of CRISPR-Cas systems with...

Published: 8/8/2024 | Inventor(s): Ilya Finkelstein, James Rybarski, Kuang Hu, Alexis Hill, Claus Wilke

Keywords(s):

Category(s): Life sciences > Research tools > Reagent

Ultra-Fast, Continuous COVID-19 Inactivation and Outbreak Control by Flexible Spray-on Coating (Case No. 2021-247)

Intro Sentence: UCLA researchers from the Department of Mechanical and Aerospace Engineering have developed a novel antibacterial and antiviral spray-on coating. Background: Smart materials present an important method of protecting public health from emerging infectious diseases such as COVID-19, severe acute respiratory syndrome (SARS), avian...

Published: 7/19/2024 | Inventor(s): Yongjie Hu, Yuan Shi, Ying Cui

Keywords(s): antimicrobial coatings, antimicrobial materials, antiviral coatings, Antiviral Drug, antivirals, continuous antiviral function, environmental disease transmission, environmental transmission, light-to-heat conversion, Microbiology, pandemic control, photothermal materials, polypyrrole, safety protocols, solar irradiation, Viral Delivery Systems

Category(s): Energy & Environment, Chemical, Chemical > Coatings, Adhesives & Inks, Medical Devices, Medical Devices > Hospital Systems

Electrically Gated Solid-State Molecular Thermal Transistor (Case No. 2024-099)

Summary: UCLA researchers have introduced a solid-state thermal transistor that achieves groundbreaking performance and facilitates improved heat flow manipulation. Background: The forefront of thermal management is marked by the exploration of molecular thermal transistors, driven by the quest for more efficient electronic devices. Researchers are...

Published: 7/16/2024 | Inventor(s): Yongjie Hu, Paul Weiss, Man Li

Keywords(s): ; self-assembled molecule, Composite Material, Doping (Semiconductor), Elastic Modulus Thermal Grease, Electronics & Semiconductors, field-effect transistors (FETs), Functional Materials, heat control, heat controlling devices, infrared thermal imaging, Microelectronics Semiconductor Device Fabrication, molecular design, molecular engineering, molecular junction, Nanomaterials, Optoelectronic materials, Optomechanical Thermal Imaging Transducer, organic field effect transistors, Organic Semiconductor, phase change materials, Rechargeable Battery Thermal Conductivity, self-assembled molecule, Semiconductor, semiconductor chip foundries, Semiconductor Device, Semiconductor Device Fabrication, Semiconductor Ohmic Contact, Semiconductor Risk Assessment, Semiconductor Sapphire, Semiconductors, solid-state thermal transistor, strength-thermal stability, switching reversibility, thermal circuit, thermal compression bonding, thermal conductance, Thermal Energy Storage, thermal fusion, thermal imaging, thermal management systems, thermal stability, thermal switching speed, thermal switching speeds, thermal transistor, Thin-Film Transistor, Transistor, transistors, zzsemiconducting materials

Category(s): Electrical, Electrical > Electronics & Semiconductors, Energy & Environment, Energy & Environment > Energy Generation, Energy & Environment > Energy Storage, Energy & Environment > Energy Transmission, Energy & Environment > Thermal, Electrical > Instrumentation, Materials, Materials > Nanotechnology

A novel process to remove carbonates from lithium-bearing sedimentary claystones

Background Climate change solutions rely on clean energy, with electric vehicles playing a crucial role in reducing greenhouse gas emissions. However, the sustainable extraction of battery materials, particularly lithium, remains challenging. Traditional extraction methods from mineral ores and brine deposits require high amounts of acid and produce...

Published: 8/21/2024 | Inventor(s): Pengbo Chu, Angela Tita, Emmanuel Mends, Sabinus Arthur

Keywords(s):

Category(s): Technology Classifications > Energy & Environment, Technology Classifications > Engineering

Cyclopropanol as a bioorthogonal warhead for electrochemically controlled bioconjugation applications

Reference #: 1685 The University of South Carolina is offering licensing opportunities for Cyclopropanol as a bioorthogonal warhead for electrochemically controlled bioconjugation applications. Background: Bioconjugation techniques play an important role in modern chemical biology and biomedical sciences, such as protein drug stabilization, target...

Published: 6/12/2024 | Inventor(s): Qian Wang, Shan Hu

Keywords(s):

Category(s): Biomedical and Life Sciences, Health Sciences

Antibodies against CD5L for therapeutic and diagnostic uses

Provided herein are anti-CD5L monoclonal antibodies. Further provided herein are methods of use thereof for the treatment of a disease or disorder, such as cancer. UTHealth Ref. No.: 2020-0016 Inventors: Dr. Zhiqiang An and Dr. Ningyan Zhang at UTHealth; Dr. Anil Sood at UT M.D. Anderson Cancer Center Patent Status: PCT application PCT/US2021/025429...

Published: 5/28/2024 | Inventor(s): Zhiqiang An, Ningyan Zhang, Anil Sood

Keywords(s):

Category(s): Biologics, Oncology, Therapeutics

Monoclonal Antibodies Against PCDH7 for Therapeutic and Diagnostic Use

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-associated deaths worldwide. UTHealth researchers discovered that the cell surface protein Protocadherin 7 (PCDH7) is highly expressed in NSCLC and promotes lung cancer development. Inventors at UTH in collaboration with Dr. O’Donnell’s group at UTSW have discovered a panel...

Published: 5/28/2024 | Inventor(s): Zhiqiang An, Ningyan Zhang, Kathryn O'Donnell

Keywords(s):

Category(s): Diagnostics, Oncology, Therapeutics, Biologics

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