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Automatic Detection and Quantification of Marine Macroalgae from Satellite Imagery

Advantages: Automates seaweed detection and quantification using satellite imagery Combines physics-based models and machine learning for accurate results Generates actionable seaweed maps at various spatial and temporal resolutions Applicable globally works on both Sargassum and Ulva blooms across different regions Summary: Massive seaweed...

Published: 3/28/2025 | Inventor(s): Chuanmin Hu, Mengqiu Wang

Keywords(s):

Category(s): Technology Classifications > Electronics > Electronics Laser, Technology Classifications > Data/AI > D/AI Imaging

Piperlongumine-Based PROTAC As Potent Anticancer Agent With Reduced Toxicity

Uses Piperlongumine as an E3 Ligase Ligand to Facilitate the Degradation of Cancer-Associated Proteins of Interest This naturally occurring compound with anti-cancer properties has the potential to revolutionize cancer treatment by providing tailored therapies with reduced side effects. Cancer remains a significant health issue in the United States,...

Published: 2/26/2025 | Inventor(s): Guangrong Zheng, Daohong Zhou, Dongwen Lyu, Yaxia Yuan, Xingui Liu, Yufeng Xiao, Wanyi Hu, Jing Pei

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Therapeutics

Enterovirus D68 capsid inhibitors as antivirals

Plaque assay results of Jun11-46-1 and Jun11-54-1 against EV-D68 US/MO/14-18947. Invention Summary: Enterovirus D68 (EV-D68) is an RNA virus that mainly affects children and results in moderate to severe respiratory illness, with the most extreme cases resulting in muscle weakness, paralysis, and death. Currently, there are no antivirals...

Published: 1/27/2025 | Inventor(s): Jun Wang, Yanmei Hu, Kan Li

Keywords(s): Antibacterial, Small molecules

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics

Small Molecule Direct Inhibitors of Keap1-Nrf2 Protein-Protein Interaction

Non-covalent direct inhibition of the Keap1-Nrf2 PPI resulting in upregulation of ARE-gene expression. Thus, increase ARE-controlled cytoprotective oxidative stress response enzymes in the development of therapeutic and preventive agents for a number of diseases and conditions. Invention Summary: The Keap1-Nrf2-ARE system could protect...

Published: 1/14/2025 | Inventor(s): Longqin Hu, Ahmed Ali

Keywords(s):

Category(s): Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Cancer

Fluorogenic bioconjugation of cyclopropanol-containing fluorophores for biological applications

Reference #: 1742 The University of South Carolina is offering licensing opportunities for Fluorogenic bioconjugation of cyclopropanol-containing fluorophores for biological applications. Background: Fluorophores have been used in various applications of cellular microbiology, most notably with the reporting functions associated with various biological...

Published: 1/13/2025 | Inventor(s): Qian Wang, Shan Hu

Keywords(s):

Category(s): Chemistry and Biochemistry

Random and Safe (RaS) Cache Architecture to Defeat Cache Timing Attacks

Random and Safe (RaS) Cache Architecture to Defeat Cache Timing Attacks Princeton Docket # 25-4192-1 Princeton University researchers have developed an innovative hardware solution known as Random and Safe (RaS) caches to address critical security vulnerabilities in modern computer systems. This technology significantly enhances security by effectively...

Published: 12/11/2024 | Inventor(s): Ruby Lee, Guangyuan Hu

Keywords(s):

Category(s): Mechanical/Electrical Engineering

Rare-Earth-Element Free Yellow Phosphors for White Light-Emitting Diodes

Yellow phosphor emits white light when excited with the 460 nm blue lighting. The blue LED (left half; top) when coated with dispersed yellow phosphor (right half; top) emits white light. Invention Summary: Despite their low energy consumption and higher efficiency, white light-emitting diodes made of blue chip coupled with yellow phosphor...

Published: 12/4/2024 | Inventor(s): Jing Li, Zhichao Hu, Qihan Gong

Keywords(s): Electronics, LEDs

Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials, Technology Classifications > Electronics/Semiconductor

S100A4 Monoclonal Antibody for Therapeutic and Diagnostic Use

Cancer metastasis are responsible for ~90% of cancer associated deaths. Recent studies suggest that immune cells play critical roles in promoting metastasis, especially myeloid cells from the bone marrow. UTHealth researchers, with researchers from The Methodist Hospital, observed a highly conserved expression of S100A4 in immune suppressive myeloid...

Published: 10/21/2024 | Inventor(s): Zhiqiang An, Ningyan Zhang

Keywords(s):

Category(s): Neurology/Neurosurgery, Oncology, Therapeutics

LILRB2 Monoclonal Antibody for Therapeutic and Diagnostic Uses of Neurodegenerative Diseases

Triggering Receptor Expressed on Myeloid cells 2 (TREM2) plays a key regulatory role in Alzheimer’s disease (AD) by controlling microglia activation and metabolic activities in brain tissues. TREM2 signaling inhibition is mediated by leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2). UTHealth inventors created and engineered...

Published: 10/21/2024 | Inventor(s): Zhiqiang An, Ningyan Zhang

Keywords(s):

Category(s): Neurology/Neurosurgery, Therapeutics

Oxynitidine Derivatives Useful as Inhibitors of Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) for Treating Cancer

Summary: The National Cancer Institute (NCI) is actively seeking potential licensees and/or co-development research collaboration partners interested in advancing oxynitidine derivatives as novel inhibitors of topoisomerase IB (TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1) for cancer treatment. These TOPI and TDP1 inhibitors, when administered...

Published: 9/18/2024 | Inventor(s): Yves Pommier, Lin-kun An, Keli Agama, Evgeny Kiselev, Azhar Ravji

Keywords(s): Benzophenanthridine Derivatives, Benzophenanthridinone, Camptothecin, Dihydrobenzophenanthridine, IRINOTECAN, Oxynitidine, Pommier, Tdp1, TOP1, Topoisomerase 1B, Topotecan, Tyrosyl-DNA Phosphodiesterase 1

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics

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