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Tumor-pH–Triggered Doxorubicin Prodrug with On-Demand Shelf-Stable Precursor
This invention introduces a small-molecule doxorubicin prodrug that remains inert in blood and rapidly activates in the mildly acidic tumor microenvironment. Featuring a shelf-stable maleimide pre-prodrug that converts on demand to the ultra-acid-labile DMA form, it enables targeted chemotherapy with improved selectivity, scalable synthesis, and reduced...
Published: 10/10/2025   |   Inventor(s): Ming An, Lan Yao, Vladyslav Nazarenko
Keywords(s): Technologies
Category(s): Campus > Binghamton University
Smart Electric Vehicle (EV) Charging and Grid Integration Apparatus and Methods (Case No. 2010-903)
Summary Researchers at UCLA have developed a smart EV charging and grid integration system that uses real-time control, state estimation, and bidirectional energy flows to manage EV charging and vehicle-to-grid (V2G) operations. The system optimizes charging schedules based on grid constraints, user preferences, and energy market signals while ensuring...
Published: 10/28/2025   |   Inventor(s): Rajit Gadh, Siddhartha Mal, Brahmavar Prabhu, Chi Cheng Chu
Keywords(s):  
Category(s): Energy & Environment, Energy & Environment > Energy Efficiency, Energy & Environment > Energy Storage, Energy & Environment > Energy Storage > Batteries
Ampule-Based Synthesis of Sulfur-Porous Carbon Composites for Lithium-Sulfur Batteries
Background Lithium/sulfur (Li/S) batteries are garnering significant attention as a promising solution for next-generation electrochemical energy storage. Their potential to revolutionize the battery industry stems from several key advantages that address the limitations of current lithium-ion (Li-ion) technology. These advantages include an exceptionally...
Published: 10/30/2025   |   Inventor(s): Yoon Hwa, David Wright, Yuhui An
Keywords(s): Chemicals, Energy storage, Engineering, Materials, Nanomaterials, Synthesis
Category(s): Energy & Power, Physical Science, Advanced Materials/Nanotechnology, Semiconductors, Materials & Processes
Machine Learning-Enhanced Aircraft Landing Schedule Algorithm
Background The civil aviation industry is losing air traffic control talents during a time when the need for maintaining daily operations is surging. This situation leads to increased operational costs, higher safety concerns, an elevated workload for air traffic controllers, and frequent flight delays. It is reported that 20% of the civil flights...
Published: 8/21/2025   |   Inventor(s): Yongming Liu, Yutian Pang, Jueming Hu
Keywords(s):  
Category(s): Physical Science, Artificial Intelligence/Machine Learning, Applied Technologies
Artificial nitrogenase enzymes for ambient-condition, decentralized ammonia production
Background Ammonia synthesis is foundational to global agriculture and chemical manufacturing, providing the primary source of fixed nitrogen for fertilizers, polymers, and pharmaceuticals. Traditional ammonia production through the Haber-Bosch process, however, operates under extreme conditions—temperatures exceeding 400°C and pressures...
Published: 9/16/2025   |   Inventor(s): Yi Lu, Hirbod Heidari, Markus Ribbe, Yilin Hu, Chi Chung Lee, Evan Mirts
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology, Life sciences > Metabolic engineering
Discovery of potent and selective D3 antagonist with alleviated hERG liability and optimized pharmacokinetic properties
One of the most challenging hurdles in creating safe and effective new medicines for many diseases is finding drugs that are effective without causing off-target cardiac issues, such as cardiac arrythmias. In collaboration with NIDA, scientists at NCATS have developed a series of novel and highly specific dopamine D3 receptor agonists and antagonists...
Published: 6/13/2025   |   Inventor(s): Khalida Shamim, Wenwei Huang, Wei Zheng, Catherine Chen, Xiuli Huang, Xin Hu, Xin Xu, Pranav Shah, Elias Padilha, Philip Sanderson, Amy Newman
Keywords(s):  
Category(s): Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Neurology, TherapeuticArea > Psychiatry/Mental Health
High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025   |   Inventor(s): Stephen Liggett, Donghwa Kim, Yu Chen, Jesper Madsen, Steven An
Keywords(s): Pharmaceuticals, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Automatic Detection and Quantification of Marine Macroalgae from Satellite Imagery
Advantages: Automates seaweed detection and quantification using satellite imagery Combines physics-based models and machine learning for accurate results Generates actionable seaweed maps at various spatial and temporal resolutions Applicable globally works on both Sargassum and Ulva blooms across different regions Summary: Massive seaweed...
Published: 6/10/2025   |   Inventor(s): Chuanmin Hu, Mengqiu Wang
Keywords(s):  
Category(s): Technology Classifications > Electronics > Electronics Laser, Technology Classifications > Data/AI > D/AI Imaging
Piperlongumine-Based PROTAC As Potent Anticancer Agent With Reduced Toxicity
Uses Piperlongumine as an E3 Ligase Ligand to Facilitate the Degradation of Cancer-Associated Proteins of Interest This naturally occurring compound with anti-cancer properties has the potential to revolutionize cancer treatment by providing tailored therapies with reduced side effects. Cancer remains a significant health issue in the United States,...
Published: 5/30/2025   |   Inventor(s): Guangrong Zheng, Daohong Zhou, Dongwen Lyu, Yaxia Yuan, Xingui Liu, Yufeng Xiao, Wanyi Hu, Jing Pei
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics
Enterovirus D68 capsid inhibitors as antivirals
​ Plaque assay results of Jun11-46-1 and Jun11-54-1 against EV-D68 US/MO/14-18947. Invention Summary: Enterovirus D68 (EV-D68) is an RNA virus that mainly affects children and results in moderate to severe respiratory illness, with the most extreme cases resulting in muscle weakness, paralysis, and death. Currently, there are no antivirals...
Published: 1/27/2025   |   Inventor(s): Jun Wang, Yanmei Hu, Kan Li
Keywords(s): Antibacterial, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
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