Search Results - dean+metcalfe

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Characterization and Comparison of LAD2 and LADR Mast Cell Lines: Insights into Mastocytosis and HIV Infection
LAD2 and LADR cell lines are invaluable tools in mast cell research, offering insights into mastocytosis and immune responses. Derived from CD34+ cells, LAD2 cells have been extensively used for over 18 years, while LADR cells, a newer variant, exhibit enhanced characteristics such as larger size, increased granulation, and faster doubling time. Both...
Published: 12/10/2024   |   Inventor(s): Arnold Kirshenbaum, Dean Metcalfe
Keywords(s):  
Category(s): Application > Research Materials, Collaboration Sought > Collaboration, ResearchProducts > Human Cell Lines, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease
A Human Progenitor Mast Cell Line for Allergic and Fibrotic Research and Therapeutic Screening
Hermansky-Pudlak Syndrome type-1 (HPS-1) is a rare genetic disorder that affects around 1 in 500,000 people worldwide and 1 in 1,800 Puerto Ricans. Patients with HPS-1 display oculocutaneous albinism, bleeding due to platelet abnormality, and pulmonary fibrosis. Those that develop pulmonary fibrosis often succumb and live no more than a decade after...
Published: 10/28/2024   |   Inventor(s): Dean Metcalfe, Arnold Kirshenbaum
Keywords(s): 16bp, c.1470-1486dup16, Cell, Cells, Cloning, Defect, DUPLICATION, EXPANSION, Expressing, FceRI, Hermansky, HPM, HPS1, Human, Immature, KNOWN, Line, Promastocyte, Pudlak, RECEPTORS, Syndrome-1
Category(s): Collaboration Sought > Collaboration
Stem Cell Factor-responsive FcepsilonRI Bearing Human Mast Cell Line LAD2
A human mast cell line LAD2 that more closely resembles normal in vivo and in vitro human mast cells by expressing functional FcepsilonRI receptors and responding to stem cell factor (SCF) with proliferation, as described in Leuk Res. 2003 Aug;27(8):677-82 and developed by the laboratory of Dr. Dean Metcalfe at the National Institute of Allergy and...
Published: 10/28/2024   |   Inventor(s): Arnold Kirshenbaum, Cem Akin, Dean Metcalfe
Keywords(s): Cell line, IA3XXX, IAXXXX, IDXXXX, IXXXXX, Mast cell disease, Mastocytosis, RM, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, TherapeuticArea > Immunology