Search Results - cardiovascular%2c+renal%2c+%26+metabolism

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Non-invasive Ocular Glucose Sensing
Project ID: D2010-12 Background Diabetes mellitus is a disease in which an individual has difficulty regulating their blood glucose levels, in which extremely low or high glucose concentrations can occur. Normal physiological blood glucose ranges are generally between 80-120 mg/dL; however, diabetics commonly have blood concentrations from 50-500...
Published: 5/9/2024   |   Inventor(s): Brent Cameron, Anthony Webb
Keywords(s):  
Category(s): Cardiovascular, Renal, & Metabolism, Diagnostics, Sensor, Medical Device
Inducing plasticity to prime immune system for CAR-Treg therapy
Project ID: D2022-28 Background Regulatory T cells (Tregs) are the critical regulators of peripheral immune tolerance; when defective, Tregs can lead to autoimmune disorders, such as Type 1 Diabetes (T1D) A more recent approach to prevent/treat autoimmunity is to refit immune cells towards their non-inflammatory phenotype in the affected organ. Chimeric...
Published: 6/18/2024   |   Inventor(s): Shahnawaz Imam, Juan Jaume
Keywords(s): CAR-T, Chimeric Antigen Receptor, EIF5A, Notch
Category(s): Cardiovascular, Renal, & Metabolism, Inflammation & Immunity
Pressure Ulcer Boot
Project ID: D2022-32 Background Pressure ulcers or bedsores form when there is a loss of circulation due to prolonged pressure at a point, such as on the heel of the foot. This occurs in immobile patients, such as those confined to a bed or wheelchair. A common way to prevent pressure ulcers is to change the position of the patient with...
Published: 5/17/2024   |   Inventor(s): Munier Nazzal, Abdullah Nasif, Karen Bauer, Mohamed Osman, Joshua Moskall, Raelyn Nyren, Mathieu Holt, Simmons Logan
Keywords(s):  
Category(s): Medical Device, Wound Healing, Cardiovascular, Renal, & Metabolism
One Step Aortic Puncher
Project Id: D2022-31 Background Patients with coronary artery disease develop this disease often over a course of decades. Deposits high in cholesterol, commonly referred to as plaque, builds up in the coronary arteries causing inflammation. This disease tends not to be noticeable until significant blockage or a heart attack occurs. Coronary bypass...
Published: 10/29/2024   |   Inventor(s): Munier Nazzal, Abdullah Nasif, Nahidh Hasaniya
Keywords(s):  
Category(s): Cardiovascular, Renal, & Metabolism, Medical Device
Cofilin inhibitor for the treatment of hemorrhagic brain injury-induced inflammation
Project ID D2019-35 Background Cofilin regulates actin filament assembly and organization in most cells, including during macrophage, T-cell, and dendritic activation and migration. Over-activation of cofilin can lead to microglia inflammation in the brain. Although Cofilin has been shown to be involved in the secondary injury of intracerebral hemorrhage...
Published: 6/18/2024   |   Inventor(s): Zahoor Shah, Saleh Alaqel, Liyanaaratchige Tillekeratne
Keywords(s): Cofilin, Hemorrhagic, Stroke
Category(s): Cardiovascular, Renal, & Metabolism, Neuroscience, Inflammation & Immunity
PEGylated Bilirubin for the treatment of Hyperlipidemia, Obesity, and Type II Diabetes
Project ID: D2018-40 Background: Obesity, a low-grade inflammatory disease, has affected more than 150 million people in the US. Obesity and its associated risk factors are a prelude to the development of type II diabetes that accounts for a vast majority of the 25.8 million diabetes cases in the US. Bilirubin, a yellow pigment produced during...
Published: 5/9/2024   |   Inventor(s): Terry Hinds, David Stec
Keywords(s): Bilirubin, Brown Adipose Tissue, Cholesterol, Obesity, PEGylated, PPARα, Triglycerides, Type II Diabetes, White Adipose Tissue
Category(s): Cardiovascular, Renal, & Metabolism
Spontaneous Type I Diabetes Mouse Model
Project ID: D2015-60 Background Although the NOD mouse is the current standard for studies of type I diabetes (T1D), no curative therapies resulting from this model have passed clinical trials. Knock in/out models cannot be used to mimic the total pathophysiology of diabetes. In order to develop a cure for T1D, there is a need for an animal model...
Published: 6/18/2024   |   Inventor(s): Juan Jaume, Maria Alfonso-Jaume, Shahnawaz Imam
Keywords(s): Diabetes, Mouse model, NOD mouse, Type I diabetes
Category(s): Tools, Cardiovascular, Renal, & Metabolism, Neuroscience, Inflammation & Immunity
Use of Small Molecule Inhibitors as Anti-Thrombotic Agents
ont-size:12px">Project ID: D2016-03 Background Various ailments, including systemic lupus erythematosus (SLE), rheumatoid arthritis and certain cancers can cause a person to suffer a thrombotic event. There are various therapies currently used for treating pro-thrombotic platelets, including molecules that can be divided into families based on mechanism...
Published: 5/9/2024   |   Inventor(s): Randall Worth, Glenn Westphal, Brenton Keeley, Leah Wuescher
Keywords(s): Anti-thrombotic, Inhibitor, Platelet, Target, Thrombosis
Category(s): Cardiovascular, Renal, & Metabolism
“Thin” Molecules for Treating Obesity and Type II Diabetes
Project ID: D2016-29 IP Status: PCT patent application filed Invention Description and Novelty: “Thin” molecules offer stronger binding to PPAR and include greater lipid burning and glucose lowering properties. Applications: Dyslipidemia, obesity and type II diabetes Value propositions: • Bilirubin reduces body...
Published: 5/9/2024   |   Inventor(s): Terry Hinds, Christopher Trabbic, David Stec
Keywords(s): Adipogenesis, Bilirubin, Biliverdin, Biliverdin Reductase, Fenofibrate, FGF21, Heme Oxygenase, Lipid Accumulation, PPAR, PPARa, WY 14,643
Category(s): Cardiovascular, Renal, & Metabolism