Search Results - yixing+chen

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Co-Deacidification and Dechlorination of Aqueous/Gaseous Streams by Mineral Dissolution (Case No. 2022-173)

Summary UCLA researchers have developed a method and composition for simultaneous deacidification and dechlorination of acidic aqueous solutions (including brines or electrolyte streams enriched in free-chlorine species), using mineral or rock solids containing low-valent metals to neutralize acidity and remove chlorine contaminants. Background Electrolytic...

Published: 9/11/2025 | Inventor(s): Gaurav Sant, David Jassby, Xin Chen, Dante Simonetti, Steven Bustillos

Keywords(s):

Category(s): Materials, Materials > Functional Materials, Materials > Membranes, Materials > Nanotechnology, Energy & Environment

Ultrasonic Process for Selective Extraction of Lithium and Magnesium From Suitable Geological Precursors and Alkaline Indust (Case No. 2022-135)

Summary UCLA researchers have developed new methods for designing and synthesizing inorganic porous materials and extracting valuable metal ions from natural and waste sources. The first technology uses metal cations as inorganic structure-directing agents to control the formation of zeolite (phillipsite) and silicate hydrate (tobermorite) phases without...

Published: 9/11/2025 | Inventor(s): Gaurav Sant, Ross Arnold, Mathieu Bauchy, Dante Simonetti, Xin Chen, David Jassby, Lawrence Anovitz, Elena Tajuelo Rodriguez

Keywords(s):

Category(s): Materials, Materials > Metals, Materials > Functional Materials, Energy & Environment

Fully Human Antibody Targeting Tumor Necrosis Factor Receptor Type 2 (TNFR2) for Cancer Immunotherapy

Abstract: Tumor necrosis factor receptor type 2 (TNFR2)-expressing regulatory T cells (Tregs), present in the tumor microenvironment, play an important role in tumor immune evasion. TNFR2 plays a crucial role in stimulating the activation and proliferation of Tregs, a major checkpoint of antitumor immune responses. In addition to its expression on Tregs,...

Published: 8/6/2025 | Inventor(s): Joost Oppenheim, Dimiter Dimitrov, De Yang, Xin Chen, Zhongyu Zhu

Keywords(s): ADCC, ANTIBODY, Antibody-dependent Cellular Cytotoxicity, CANCER, Immunotherapy, Oppenheim, TNFR2, Tregs, Tumor Necrosis Factor Receptor Type 2

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology

Novel Multi-Omics Aging Clock

A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...

Published: 3/12/2024 | Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen

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Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools

Autonomous Drone for railroad track inspection

Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...

Published: 8/26/2025 | Inventor(s): Yu Qian, Yi Wang, Chen Chen

Keywords(s): autonomous drone, flight control, image processing, railroad track inspection, self-navigation

Category(s): Engineering and Physical Sciences

Engineered globular endolysin, a highly potent antibacterial enzyme for multidrug resistant Gram-negative bacteria

[Licensing negotiation in progress] [Invitation for Expression of Interest- Deadline 2 July 2021] We are inviting expressions of interest (EoI) for commercializing “Engineered Globular Endolysin, a Highly Potent Antibacterial Enzyme for Multidrug Resistant Gram-Negative Bacteria” technology. The innovation is developed by Professor XIA...

Published: 10/17/2023 | Inventor(s): Jiang XIA, Shui Yee LEUNG, Xi CHEN, Miao LIU

Keywords(s):

Category(s): Biotechnology, Therapeutics

Targeted Neoantigen Vaccination in H3G34R/V Glioma (UCLA Case No. 2021-008)

UCLA researchers in the Departments of Neurosurgery and Microbiology, Immunology, and Molecular Genetics have developed an immunotherapy treatment methodology for H3G34R/V high-grade glioma, providing an ability to be adapted toward a wide range of similar tumors.BACKGROUND:Over 3000 gliomas and other forms of brain cancer are diagnosed in children...

Published: 7/31/2025 | Inventor(s): Anthony Wang, Geoffrey Owens, Yi Xing, Robert Prins, Linda Liau, David Nathanson

Keywords(s): Immunotherapy, Oncology, Oncology Immunotherapy

Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology, Therapeutics > Oncology > Oncology Immunotherapy

2015-671 Underground Shafts for Hydrogen Storage

SummaryResearchers at UCLA have developed an underground drilled shaft concept for storage of hydrogen or other gases.BackgroundOne challenge in creating a hydrogen economy is developing hydrogen gas storage solutions. Increased interest has helped the global hydrogen storage market grow to $2.6 billion in 2016, and it is expected to reach over $5...

Published: 7/17/2025 | Inventor(s): Adrienne Lavine, Hossein Kavehpour, Dante Simonetti, Richard Wirz, Chen Chen, Gabriela Bran, Gopinath Warrier, Hamarz Aryafar, Jonathon Kennedy, Joshua Jordan, Keith Lovegrove

Keywords(s): Energy & Water

Category(s): Energy & Environment > Energy Generation > Solar, Energy & Environment > Energy Storage

Identification of a Platform for T Cell Receptor Recognition of Splice Variation Neoantigens in Glioblastoma (UCLA Case No. 2019-693)

UCLA researchers in the Departments of Neurosurgery and Pharmacology have developed a novel platform for the identification of alternative splice variants unique to cancer cells, for use as neo-epitope vaccines or as T cell Receptor-based cell therapy of brain cancer. BACKGROUND:T cells are a type of lymphocyte that play a central role in immune response...

Published: 7/31/2025 | Inventor(s): Robert Prins, Yi Xing

Keywords(s): Diagnostic Markers & Platforms, Oncology, Therapeutics & Vaccines

Category(s): Diagnostic Markers, Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy

IRIS: Isoform Peptides from RNA Sequencing for Immunotherapy Targets Screening

UCLA Case No. 2018-916SUMMARYResearchers led by Dr. Xing from the Department of Microbiology, Immunology, and Molecular Genetics at UCLA have developed a big data approach to identify targets for personalized cancer immunotherapy. BACKGROUNDImmunotherapies aim to use the patient’s own immune system to fight cancerous cells, but to be...

Published: 2/14/2025 | Inventor(s): Yi Xing, Yang Pan, Harry Yang, Yuanyuan Wang

Keywords(s):

Category(s): Diagnostic Markers > Immunology, Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Therapeutics > Oncology > Oncology (Small Molecules), Software & Algorithms > Data Analytics

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