Search Results - yixing+chen

10 Results Sort By:
Fully Human Antibody Targeting Tumor Necrosis Factor Receptor Type 2 (TNFR2) for Cancer Immunotherapy
Abstract: Tumor necrosis factor receptor type 2 (TNFR2)-expressing regulatory T cells (Tregs), present in the tumor microenvironment, play an important role in tumor immune evasion. TNFR2 plays a crucial role in stimulating the activation and proliferation of Tregs, a major checkpoint of antitumor immune responses. In addition to its expression on Tregs,...
Published: 5/22/2024   |   Inventor(s): Joost Oppenheim, Dimiter Dimitrov, De Yang, Xin Chen, Zhongyu Zhu
Keywords(s): ADCC, ANTIBODY, Antibody-dependent Cellular Cytotoxicity, CANCER, Immunotherapy, Oppenheim, TNFR2, Tregs, Tumor Necrosis Factor Receptor Type 2
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology
Novel Multi-Omics Aging Clock
­A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 3/12/2024   |   Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools
Autonomous Drone for railroad track inspection
Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...
Published: 3/15/2023   |   Inventor(s): Yu Qian, Yi Wang, Chen Chen
Keywords(s): autonomous drone, flight control, image processing, railroad track inspection, self-navigation
Category(s): Engineering and Physical Sciences
Engineered globular endolysin, a highly potent antibacterial enzyme for multidrug resistant Gram-negative bacteria
[Licensing negotiation in progress] [Invitation for Expression of Interest- Deadline 2 July 2021] We are inviting expressions of interest (EoI) for commercializing “Engineered Globular Endolysin, a Highly Potent Antibacterial Enzyme for Multidrug Resistant Gram-Negative Bacteria” technology. The innovation is developed by Professor XIA...
Published: 10/17/2023   |   Inventor(s): Jiang XIA, Shui Yee LEUNG, Xi CHEN, Miao LIU
Keywords(s):  
Category(s): Biotechnology, Therapeutics
Targeted Neoantigen Vaccination in H3G34R/V Glioma (UCLA Case No. 2021-008)
UCLA researchers in the Departments of Neurosurgery and Microbiology, Immunology, and Molecular Genetics have developed an immunotherapy treatment methodology for H3G34R/V high-grade glioma, providing an ability to be adapted toward a wide range of similar tumors.BACKGROUND:Over 3000 gliomas and other forms of brain cancer are diagnosed in children...
Published: 5/4/2024   |   Inventor(s): Anthony Wang, Geoffrey Owens, Yi Xing, Robert Prins, Linda Liau, David Nathanson
Keywords(s): Immunotherapy, Oncology, Oncology Immunotherapy
Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology, Therapeutics > Oncology > Oncology Immunotherapy
2015-671 Underground Shafts for Hydrogen Storage
SummaryResearchers at UCLA have developed an underground drilled shaft concept for storage of hydrogen or other gases.BackgroundOne challenge in creating a hydrogen economy is developing hydrogen gas storage solutions. Increased interest has helped the global hydrogen storage market grow to $2.6 billion in 2016, and it is expected to reach over $5...
Published: 7/19/2023   |   Inventor(s): Adrienne Lavine, Hossein Kavehpour, Dante Simonetti, Richard Wirz, Chen Chen, Gabriela Bran, Gopinath Warrier, Hamarz Aryafar, Jonathon Kennedy, Joshua Jordan, Keith Lovegrove
Keywords(s): Energy & Water
Category(s): Energy & Environment > Energy Generation > Solar, Energy & Environment > Energy Storage
Identification of a Platform for T Cell Receptor Recognition of Splice Variation Neoantigens in Glioblastoma (UCLA Case No. 2019-693)
UCLA researchers in the Departments of Neurosurgery and Pharmacology have developed a novel platform for the identification of alternative splice variants unique to cancer cells, for use as neo-epitope vaccines or as T cell Receptor-based cell therapy of brain cancer. BACKGROUND:T cells are a type of lymphocyte that play a central role in immune response...
Published: 5/20/2024   |   Inventor(s): Robert Prins, Yi Xing
Keywords(s): Diagnostic Markers & Platforms, Oncology, Therapeutics & Vaccines
Category(s): Diagnostic Markers, Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy
IRIS: Isoform Peptides from RNA Sequencing for Immunotherapy Targets Screening
UCLA Case No. 2018-916SUMMARYResearchers led by Dr. Xing from the Department of Microbiology, Immunology, and Molecular Genetics at UCLA have developed a big data approach to identify targets for personalized cancer immunotherapy. BACKGROUNDImmunotherapies aim to use the patient’s own immune system to fight cancerous cells, but to be...
Published: 7/19/2023   |   Inventor(s): Yi Xing, Yang Pan, Taegyun Yang, Yuanyuan Wang
Keywords(s):  
Category(s): Diagnostic Markers > Immunology, Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Therapeutics > Oncology > Oncology (Small Molecules), Software & Algorithms > Data Analytics
DARTS: Deep Learning Augmented RNA-seq Analysis of Transcript Splicing
SummaryResearchers led by Yi Xing have developed a novel deep learning algorithm to detect alternative splicing patterns in RNA-seq dataBackgroundDevelopment of genetic sequencing tools like RNA-seq has ushered in an age of big data in genomics and transcriptomics. Collective efforts like ENCODE and the Roadmap Epigenomics Project (REP) have accelerated...
Published: 7/19/2023   |   Inventor(s): Yi Xing, Zijun Zhang
Keywords(s): Life Science Research Tools, Nucleic Acid Platform Systems, Research Methods, Software, Targets And Assays, Therapeutics & Vaccines
Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Therapeutics, Software & Algorithms > Programs
Ocular Ultrasound Training Simulator (OUTS)
Project ID: D2018-28Background The use of ocular ultrasound on emergency patients has recently been adopted by emergency physicians to evaluate for ocular pathology and emergencies. Point of care ultrasound (POCUS) has been found to be highly accurate in diagnosing and evaluating for ocular pathology in patients presenting in emergency departments....
Published: 6/18/2024   |   Inventor(s): Kelley Stanko, Yixing Chen, Daniel Brainard
Keywords(s): Eye model, Ocular, Phantom , Simulation, Training, Ultrasound
Category(s): Head/Neck, Tools