Search Results - xiaoping+wang

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The First Curative Treatment of Phenylketonuria Using Genetic Engineering Approaches
The base editing of phenylalanine hydroxylase enzyme in the liver to restore phenylalanine metabolism and prevent neurotoxic effects. Problem: Phenylketonuria (PKU) is a severe disorder affecting approximately 1 in 10,000 U.S. newborns. PKU is marked by a genetic mutation in the phenylalanine hydroxylase enzyme (PAH), resulting in phenylalanine (Phe)...
Published: 10/28/2024   |   Inventor(s): Kiran Musunuru, Xiao Wang, Dominique Brooks
Keywords(s): Gene Editing, Gene Therapy, Genetic Disorders, Neurodegenerative Diseases, Neurology
Category(s): Technology Classifications > Therapeutics
High-throughput RNA sequencing technology for comprehensive transcriptome profiling and biomarker identification in inflammatory breast cancer
The technology utilizes TGIRT-seq, a high-throughput RNA sequencing method, to identify potential biomarkers for inflammatory breast cancer by profiling coding and non-coding RNAs in tumor and blood samples, aiding in diagnosis and disease monitoring. Background Inflammatory breast cancer (IBC) is recognized as the most aggressive form of breast cancer,...
Published: 10/22/2024   |   Inventor(s): Alan Lambowitz, Dennis Wylie, Lauren Ehrlich, Elizabeth Kiddie, Hengyi Xu, Jun Yao, Naoto Ueno, Xiaoping Wang
Keywords(s):  
Category(s): Life sciences > Diagnostic
LNP Delivery of Gene-Editing Machinery to Cure Hereditary Tyrosinemia Type 1g
Problem: Hereditary tyrosinemia type 1 (HT1) is a genetic metabolic disease caused by the inability to break down tyrosine, an amino acid present in many meats, dairy products, fruits, and nuts. This disease can be fatal within the first few months of life and increases the risk of liver cancer. The current treatment involves a strict drug regimen and...
Published: 7/10/2024   |   Inventor(s): Kiran Musunuru, Madelynn Whittaker, Xiao Wang, William Peranteau, Cara Berkowitz, Ana Dumitru
Keywords(s): Gene Editing, Genetic Disorders, Obesity, Metabolic Disease and Diabetes
Category(s): Technology Classifications > Therapeutics
Synthetic Gene Circuits
­Engineering synthetic gene circuits allows scientists to design cells to perform any number of tasks such as biosensing, therapeutic or commodity production or bioremediation to name a few. An important design principle when engineering sophisticated synthetic gene circuits is modularity as it breaks the system down into small modules, thereby...
Published: 2/23/2023   |   Inventor(s): Rong Zhang, Hanah Goetz, Juan Melendez-Alvarez, Xiao Wang, Xiaojun Tian
Keywords(s):  
Category(s): Computing & Information Technology, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
Development of an artificial intelligence analysis method for magnetic particle imaging using a machine learning algorithm
iNTRODUCTION A magnetic particle imaging (MPI) device uses a changing magnetic field to cause superparamagnetic iron oxide (SPIO) nanoparticles to produce a signal upon exposure. The MPI device then detects these signals and produces a high contrast image. These images are useful in tracking SPIO throughout the body. This is useful in tracking transplanted...
Published: 6/25/2024   |   Inventor(s): Ping Wang, Hasaan Hayat, Jinda Fan
Keywords(s):  
Category(s): Medical, Computer Software, Data Processing/Analysis
A Mutually Inhibitory Network with Positive Autoregulation and Communications (MINPAC)
Biological pattern formation requires complex gene regulation networks and accurate cell-cell coordination. The reaction-diffusion (RD) based clock and wavefront model has been proposed as a mechanism involved in biological pattern formation of repeated and segmented structures. While RD driven pattern formation has been demonstrated in many systems,...
Published: 2/23/2023   |   Inventor(s): Fuqing Wu, Samat Bayakhmetov, Changhan He, Qi Zhang, Xingwen Chen, Yang Kuang, Xiao Wang
Keywords(s):  
Category(s): Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Computing & Information Technology
Base-Edited Isogenic hPSC Line Generation (BIG-TREE)
Human pluripotent stem cells (hPSCs) are a vital tool not only in research and disease modeling but also in developmental biology and regenerative medicine because of their ability to self-renew and differentiate. Current genome editing tactics in hPSCs require the incorporation of deleterious double-stranded DNA breaks followed by inefficient homology-directed...
Published: 2/23/2023   |   Inventor(s): David Brafman, Xiao Wang, Nicholas Brookhouser, Stefan Tekel, Kylie Standage-Beier
Keywords(s):  
Category(s): Life Science (All LS Techs), Genomic Assays/Reagents/Tools
Pathogen Molecular Detection Platform
Accurate detection and diagnosis of infectious diseases is paramount to appropriate treatment and better outcomes. Despite tremendous efforts to advance new diagnostic techniques, there are still critical gaps in the healthcare system in quickly diagnosing and responding to infectious diseases. Current diagnostic technologies identify pathogens by detecting...
Published: 2/23/2023   |   Inventor(s): Qi Zhang, Xiao Wang, Alexander Green, Duo Ma, Fuqing Wu, Kylie Standage-Beier, Xingwen Chen
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Genomic Assays/Reagents/Tools, Proteomic Assays/Reagents/Tools, Medical Diagnostics/Sensors
Targeted Remodeling of Bacterial Genomes Using CRISPR-Nickases
Targeting DNA manipulation is integral to biotechnology and synthetic biology. Large chromosomal rearrangements and deletions have profound impacts on bacterial physiology, such as improved bioproduct levels, increased strain fitness, or changed tolerance to stress and environmental conditions. However, it requires time-consuming and laborious directed...
Published: 2/23/2023   |   Inventor(s): Xiao Wang, Kylie Standage-Beier
Keywords(s): Biological Cell Manipulation, Bio-Technology
Category(s): Alternative Energy/Biofuels/Bioplastics/Algae, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
Model for Gene Expression Tuning and Synthetic Gene Circuit Construction
Genetic circuit engineering has played an important role in many forms of synthetic biology. Based on a large collection of well characterized biological components, complex gene circuits with designed functions can be wired using established biological principles. Currently circuit assembly has two main strategies: one is monocistronic construct, in...
Published: 2/23/2023   |   Inventor(s): Fuqing Wu, Xiao Wang, Qi Zhang
Keywords(s):  
Category(s): Computing & Information Technology, Genomic Assays/Reagents/Tools, Proteomic Assays/Reagents/Tools, Life Science (All LS Techs)
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