Search Results - alan+lambowitz

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High-throughput RNA sequencing technology for comprehensive transcriptome profiling and biomarker identification in inflammatory breast cancer
The technology utilizes TGIRT-seq, a high-throughput RNA sequencing method, to identify potential biomarkers for inflammatory breast cancer by profiling coding and non-coding RNAs in tumor and blood samples, aiding in diagnosis and disease monitoring. Background Inflammatory breast cancer (IBC) is recognized as the most aggressive form of breast cancer,...
Published: 10/22/2024   |   Inventor(s): Alan Lambowitz, Dennis Wylie, Lauren Ehrlich, Elizabeth Kiddie, Hengyi Xu, Jun Yao, Naoto Ueno, Xiaoping Wang
Keywords(s):  
Category(s): Life sciences > Diagnostic
Thermotargetron for modifying thermophilic microorganisms
The Thermotargetron is a genetic tool for modifying thermophilic micro­organisms using a type-II intron element, TeI3c‑4c. It allows efficient gene inactivation across a broad host range without needing selection markers and can target short gene sequences. Background Renewable fuels like bioethanol are increasingly vital due to rising global...
Published: 8/9/2024   |   Inventor(s): Alan Lambowitz, Georg Mohr, Wei Hong, Qui Cui, Ya-Jun Liu
Keywords(s):  
Category(s): Life sciences > Immunology > Genomics/genetics, Life sciences > Research tools > Tool/assay/screening platform, Physical sciences > Energy > Renewable
Fusion protein technology for site‑specific integration of RNA into DNA genomes
The technology integrates target RNA into DNA genomes by adding short DNA tails to RNA. Direct RNA integration into CRISPR arrays eliminates the use of harsh transfection methods that fragment DNA sequences. Background The development of CRISPR-Cas systems, which are widely used for precise genetic modifications, has advanced the field of genome...
Published: 7/25/2024   |   Inventor(s): Alan Lambowitz, Georg Mohr
Keywords(s):  
Category(s): Life sciences, Life sciences > Therapeutics > Gene editing
Full-length excised intron RNA sequencing and analysis for disease diagnosis
Problem RNA molecules that are newly transcribed from the corresponding DNA sequence contain intron and exon sequences. Introns are removed by a process called RNA splicing, where the introns are removed and the exons are ligated to form the mature messenger RNA (mRNA) and full-length excised intron RNAs (FLEXIRs). The majority of FLEXIRs and the genes...
Published: 8/15/2024   |   Inventor(s): Alan Lambowitz, Hengyi Xu, Douglas Wu, Jun Yao
Keywords(s):  
Category(s): Life sciences > Diagnostic, Life sciences > Research tools > Tool/assay/screening platform
Engineered Group II Intron reverse transcriptase for high-resolution RNA analysis
Background The patent portfolio covering group II intron and related reverse transcriptase developed by Dr. Alan Lambowitz at UT Austin, including the highly efficient Thermostable Group II Intron Reverse Transcriptase (TGIRT) enzyme, is available for licensing and commercialization. As many high-profile publications have demonstrated, TGIRT has higher...
Published: 5/29/2024   |   Inventor(s): Alan Lambowitz, Jennifer Stamos, Alfred Lentzsch, Seung Park, Georg Mohr
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform