Search Results - wei-heng+shih

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Broadly Neutralizing Antibodies Against HIV-1 Directed to the CD4 Binding Site of HIV Envelope Protein
Inhibiting the ability of HIV-1, the virus that causes AIDS, to infect cells is one approach to both prevention and treatment of HIV. Scientists at the NIAID Vaccine Research Center have isolated and characterized neutralizing antibodies (VRC01, 02, 03, and 07) that bind to the CD4 binding site of HIV-1 envelope glycoprotein gp120. These human monoclonal...
Published: 7/25/2024   |   Inventor(s): Richard Wyatt, Xueling Wu, Yuxing Li, Carl-Magnus Hogerkorp, Mario Roederer, Zhi-yong Yang, Gary Nabel, Peter Kwong, Tongqing Zhou, Mark Connors, Gilad Ofek, Yongping Yang, Jiang Zhu, Lawrence Shapiro, William Schief, Rebecca Rudicell, Ivelin Georgiev, Young Do Kwon, Baoshan Zhang, Gwo-yu Chauang, Wei Shi, Gwo-Yu Chuang, John Mascola
Keywords(s): Against, antibodies, Antibodies., ANTIBODY, Antibody-based, B-Cells, Broadly, Chain, Constructs, CREATION, DA4AXX, DB4AXX, DC5AXX, DD2XXX, Epitope-Specific, Expressing, FUNCTION, Further, GENERAL, GLYCOPROTEIN, gp120, HIV, HIV-1, Identity, Immunoadesion, Immunoadhesin, Isolation, Listed LPM Thalhammer-Reyero as of 4/15/2015, MODE, Modifications, monoclonal, Monoco, Neutizing, Neutralization, Neutralizing, Novel, Patent Category - Biotechnology, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Probes, Single, Specific, VRC03, VRC03Isolation
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials
Zika Virus Vaccines
Zika virus (ZIKV) is a flavivirus transmitted by mosquitos that is strongly linked to neurological complications including Guillain-Barré syndrome, meningoencephalitis, and microcephaly. The association between active ZIKV infection during pregnancy and microcephaly and intrauterine growth retardation in the fetus has been confirmed in murine models...
Published: 7/25/2024   |   Inventor(s): John Mascola, Wing-pui Kong, Eun Yang, Wei Shi, Theodore Pierson, Leda Castilho, Kimberly Dowd, Lingshu Wang, Christina Demaso, Rebecca Pelc, Adrian Creanga, Julie Ledgerwood, Sebastian Ramesch, Barney Graham
Keywords(s): Chimera, DC5BXX, GENE-BASED, JAPANESE ENCEPHALITIS VIRUS, vaccines, virus-like particles, VLP, Zika
Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease
Hybrid Plasmonic Platform for Directing and Controlling Nanostructure Growth
Low-Heat, Bottom-Up Approach Can Produce Metal, Polymer or Bio-Molecule Structures for Catalysis, Biosensors, Electronic Devices and MoreThis surface plasmon mediated chemical solution deposition method uses surface plasmon resonance to deposit nanoparticles in the liquid phase at room temperature to direct and control nanostructure growth. Plasmonic...
Published: 6/27/2021   |   Inventor(s): Wei Wei, Jingjing Qiu
Keywords(s): Catalysts, nanoparticle synthesis, Plasmonic, Thin Films
Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Engineering > Materials
Enhanced detection sensitivity with piezoelectric sensors
PAGE TITLEOverviewPAGE SUMMARY A method for enhancing the detection sensitivity of a piezoelectric microcantilever sensor. The method may involve providing a piezoelectric microcantilever and inducing a change in the Young's modulus during detection of a species of interest. The change in the Young's modulus may be induced or enhanced by the application...
Published: 7/11/2024   |   Inventor(s): Wan Shih, Wei-Heng Shih, Qing Zhu
Keywords(s): Ceramic Sensors, In-vitro diagnostics
Category(s): Medical Devices & Diagnostics, Hardware, Circuits & Sensors, Medical Devices & Diagnostics > MDD: Diagnostic Tests, Medical Devices & Diagnostics > MDD: Point of Care Diagnostics, Hardware, Circuits & Sensors > Hardware: Biological Sensors, Hardware, Circuits & Sensors > Hardware: Chemical Sensors
FLOW-BASED ENHANCEMENT OF SPECIFICITY FOR LABEL-FREE BIOCHEMICAL ASSAYS
PAGE TITLEOverviewPAGE SUMMARY A label-free biochemical assay, in which label-free interrogation of a target-receptor layer is performed while the target-receptor layer is subjected to a relatively strong flow of an analyte-containing fluid. The volumetric flow rate for the assay is selected based on calibration data corresponding to the target substance,...
Published: 7/11/2024   |   Inventor(s): Wan Shih, Wei-Heng Shih, John-Paul Mcgovern
Keywords(s):  
Category(s): Medical Devices & Diagnostics, Hardware, Circuits & Sensors, Medical Devices & Diagnostics > MDD: Diagnostic Tests, Medical Devices & Diagnostics > MDD: Point of Care Diagnostics, Hardware, Circuits & Sensors > Hardware: Biological Sensors, Hardware, Circuits & Sensors > Hardware: Chemical Sensors
Lead-free piezoelectric ceramic films and a method for making thereof
PAGE TITLEOverviewPAGE SUMMARY This invention relates to lead-free piezoelectric ceramic films and a method of making thereof. Specifically, the invention is directed to a method for fabricating lead-free piezoelectric free standing films having enhanced piezoelectric properties. The films may be used for a number of applications including incorporation...
Published: 7/11/2024   |   Inventor(s): Wei-Heng Shih, Wan Shih, Huidong Li
Keywords(s): Ceramic Sensors
Category(s): Materials & Chemicals, Medical Devices & Diagnostics, Hardware, Circuits & Sensors, Materials & Chemicals > M-C: Ceramics, Materials & Chemicals > M-C: Chemicals and Processes, Materials & Chemicals > M-C: Electronic/Conductive, Medical Devices & Diagnostics > MDD: Diagnostic Tests, Medical Devices & Diagnostics > MDD: Point of Care Diagnostics, Hardware, Circuits & Sensors > Hardware: Biological Sensors, Hardware, Circuits & Sensors > Hardware: Chemical Sensors
Specificity and sensitivity enhancement in cantilever sensing
PAGE TITLEOverviewPAGE SUMMARY The invention is directed to a sensor system including at least one sensor and target specific receptors bound substrates for purposes of enhancing detection sensitivity. Optionally, the sensor system may include quantum dots for independently verifying the presence of a target molecule or compound. The sensor system may...
Published: 7/11/2024   |   Inventor(s): Wei-Heng Shih, Wan Shih
Keywords(s):  
Category(s): Medical Devices & Diagnostics, Materials & Chemicals, Hardware, Circuits & Sensors, Materials & Chemicals > M-C: Coatings, Materials & Chemicals > M-C: Electronic/Conductive, Medical Devices & Diagnostics > MDD: Diagnostic Tests, Medical Devices & Diagnostics > MDD: Point of Care Diagnostics, Hardware, Circuits & Sensors > Hardware: Biological Sensors, Hardware, Circuits & Sensors > Hardware: Chemical Sensors
Non-invasive melanoma thickness measurement
PAGE TITLEOverviewPAGE SUMMARY Melanoma is a malignant tumor of melanocytes, which are melanin-producing cells located predominately in the skin. Melanoma is one of the most aggressive and deadly types of cancer. Approximately 80,000 new cases of invasive melanoma are diagnosed in the United States, and about 10,000 people die of the disease annually....
Published: 7/24/2024   |   Inventor(s): Wan Shih, Wei-Heng Shih, Xin Xu
Keywords(s):  
Category(s): Hardware, Circuits & Sensors, Medical Devices & Diagnostics, Medical Devices & Diagnostics > MDD: Diagnostic Tests, Medical Devices & Diagnostics > MDD: Point of Care Diagnostics, Hardware, Circuits & Sensors > Hardware: Biological Sensors
Rapid Antimicrobial Susceptibility Testing using Piezoelectric Sensor
PAGE TITLEOverviewPAGE SUMMARY In the U.S., each year at least 2 million people acquire serious infections with bacteria resistant to one or more of the antibiotics, resulting in >$20 billion in direct healthcare costs and $35 billion in lost productivity. In particular, nosocomial bloodstream infections (BSI’s), including catheter-related...
Published: 5/19/2022   |   Inventor(s): Wan Shih, Wei-Heng Shih, Xin Xu, Christopher Emery, Suresh Joshi, Wei Wu
Keywords(s):  
Category(s): Materials & Chemicals, Medical Devices & Diagnostics, Materials & Chemicals > M-C: Electronic/Conductive, Materials & Chemicals > M-C: Coatings, Medical Devices & Diagnostics > MDD: Diagnostic Tests, Medical Devices & Diagnostics > MDD: Point of Care Diagnostics
Piezoelectric Plate Sensor (PEPS)
PAGE TITLEOverview PAGE SUMMARY Improving sensitivity, accuracy and efficiency of piezoelectric sensors for detecting biomolecules is important to the development of sensitive and reliable assays in the healthcare field for early detection and prevention of diseases. To achieve sub-femtomolar sensitivity, Drexel’s researchers have developed a...
Published: 7/12/2024   |   Inventor(s): Wan Shih, Wei-Heng Shih, Wei Wu, Mehmet Cagri Soylu, Ceyhun Ekrem Kirimli, Suresh Joshi, Haitao Guo, Ying-Hsiu Su
Keywords(s):  
Category(s): Medical Devices & Diagnostics, Hardware, Circuits & Sensors, Materials & Chemicals, Materials & Chemicals > M-C: Chemicals and Processes, Materials & Chemicals > M-C: Coatings, Materials & Chemicals > M-C: Electronic/Conductive, Medical Devices & Diagnostics > MDD: Diagnostic Tests, Medical Devices & Diagnostics > MDD: Point of Care Diagnostics, Hardware, Circuits & Sensors > Hardware: Biological Sensors, Hardware, Circuits & Sensors > Hardware: Chemical Sensors
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