Search Results - virus-like+particles

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Method for Targeted Therapeutic Delivery of Proteins into Cells
Abstract: Current methods to deliver proteins into cells (e.g., using retrovirus, DNA transfection, protein transduction, microinjection, complexing the protein with lipids, etc.) have many shortcomings, such as lack of target specificity toxicity, or unwanted random integration into the host chromosome.  Protein transduction is an emerging technology...
Published: 4/8/2024   |   Inventor(s): Deb Chatterjee, Stanislaw Kaczmarczyk
Keywords(s): virus-like particles, VLP
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Application > Non-Medical Devices, Application > Medical Devices
Virus-Like Particles That Can Deliver Proteins and RNA
Abstract: The National Cancer Institute's Protein Expression Laboratory seeks parties interested in licensing the novel delivery of RNA to mammalian cells using virus-like particles. Current methods of delivering proteins or RNA to mammalian cells are limited by a lack of target specificity and toxicity, among other shortcomings.  NCI researchers have...
Published: 4/8/2024   |   Inventor(s): Stanislaw Kaczmarczyk, Deb Chatterjee
Keywords(s): antibody synthesis, Protein Expression, RNA delivery, virus-like particles
Category(s): Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease
Zika Virus Vaccines
Zika virus (ZIKV) is a flavivirus transmitted by mosquitos that is strongly linked to neurological complications including Guillain-Barré syndrome, meningoencephalitis, and microcephaly. The association between active ZIKV infection during pregnancy and microcephaly and intrauterine growth retardation in the fetus has been confirmed in murine models...
Published: 10/28/2024   |   Inventor(s): John Mascola, Wing-pui Kong, Eun Yang, Wei Shi, Theodore Pierson, Leda Castilho, Kimberly Dowd, Lingshu Wang, Christina Demaso, Rebecca Pelc, Adrian Creanga, Julie Ledgerwood, Sebastian Ramesch, Barney Graham
Keywords(s): Chimera, DC5BXX, GENE-BASED, JAPANESE ENCEPHALITIS VIRUS, vaccines, virus-like particles, VLP, Zika
Category(s): Collaboration Sought > Licensing, Application > Vaccines, TherapeuticArea > Infectious Disease