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Search Results - lingshu+wang
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ASC-Targeted Nanoparticles for Browning White Adipose Tissue and Combatting Obesity and Metabolic Diseases
Invention Description Obesity and related metabolic diseases are increasing in prevalence in the US and worldwide. They are difficult to treat with traditional therapies such as lifestyle intervention, pharmacotherapy, and various surgical procedures because of low compliance, low efficacy, high side effects and cost. One promising new approach focuses...
Published: 1/12/2026
|
Inventor(s):
Shu Wang
,
Aysegul Kartal Acet
,
Fang Zhou
Keywords(s):
Category(s):
Biological Nanotechnology
,
Non-Cancer Therapeutics
,
Nucleic Acid/Peptide/Protein Therapies
,
Pharmaceuticals
Transgenic Mouse Model for Marfan Syndrome Research
Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...
Published: 12/23/2025
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Inventor(s):
Li Li
,
Shichao Wu
,
Jiawei Zhao
Keywords(s):
Category(s):
Technology Category > Research tools
,
Technology Category > Animal models
,
Technology Category > Biology
,
Technology Category > Diagnostic
Ultrafast Thin-Film Vapor Deposition Technique
Invention Description The demand for advanced thin-film deposition techniques has grown substantially in recent years, driven by the development of next-generation electronic, optoelectronic, and energy devices. Traditional deposition methods, such as chemical vapor deposition, molecular beam epitaxy, and physical vapor deposition, have well-established...
Published: 11/18/2025
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Inventor(s):
Feng Yan
,
Lin Li
Keywords(s):
Category(s):
Semiconductors, Materials & Processes
,
Microelectronics
,
Physical Science
,
Semiconductor Devices
,
Manufacturing/Construction/Mechanical
Brain-Targeted Nanoparticles for Delivering Agents to the Brain
The blood brain barrier (BBB) is a highly selective semipermeable complex, and only about 2% of small molecules in the blood can penetrate it. Because of this, drug delivery to the brain is fairly ineffective. Research into receptors expressed on the BBB is promising, however, many receptors (glucose transporter 1, transferrin receptor, LDL-receptor...
Published: 8/27/2025
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Inventor(s):
Shu Wang
,
Zhaoyang Fan
Keywords(s):
Category(s):
Biological Nanotechnology
,
Diagnostic Assays/Devices
,
Imaging
,
Life Science (All LS Techs)
,
Pharmaceuticals
,
Medical Imaging
,
Non-Cancer Therapeutics
Innovative Multifunctional Edible Coating for Enhancing Fresh Produce
Fresh fruits and vegetables (FVs) can cause foodborne diseases as they are able to harbor a variety of human pathogens and parasites. The short shelf life of fresh produce, due in large part to microbial induced spoilage, is a serious problem that costs the food industry billions a year. Further, nutrients, polyphenols and other bioactive compounds...
Published: 12/2/2025
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Inventor(s):
Shu Wang
,
Zhaoyang Fan
Keywords(s):
Category(s):
Advanced Materials/Nanotechnology
,
Agriculture/Animal Health
,
Life Science (All LS Techs)
Resveratrol and Quercetin-Loaded Nanoparticles
Obesity and related metabolic diseases are a significant public health issue in the US and worldwide. Studies have shown that pathologically expanded white adipose tissue is associated with multiple obesity-related comorbidities including diabetes, cardiovascular disease as well as certain types of cancer. Current strategies to combat obesity and metabolic...
Published: 2/13/2025
|
Inventor(s):
Shu Wang
,
Fang Zhou
,
Corrie Whisner
,
Zhaoyang Fan
Keywords(s):
Category(s):
Nutraceuticals/Extracts
,
Advanced Materials/Nanotechnology
,
Life Science (All LS Techs)
,
Non-Cancer Therapeutics
Nanoencapsulation of Forskolin for Combatting Obesity
Obesity and related metabolic diseases are increasing in prevalence in the US and worldwide. Pathologically expanded white adipose tissue (WAT) has been associated with multiple obesity-related comorbidities including diabetes, cardiovascular disease, cancers and more. Lifestyle intervention, pharmacotherapy, and various surgical procedures are used...
Published: 2/13/2025
|
Inventor(s):
Shu Wang
,
Zhaoyang Fan
Keywords(s):
Category(s):
Advanced Materials/Nanotechnology
,
Life Science (All LS Techs)
,
Pharmaceuticals
,
Non-Cancer Therapeutics
,
Nutraceuticals/Extracts
Functionalized Bacterial Cellulose Nanofiber-Based Battery Separators
Background Lithium metal batteries (LMBs), including lithium sulfur batteries (LSBs), use lithium metal as the anode instead of the conventional graphite anode used in lithium-ion batteries (LIBs), and can deliver an energy density that is significantly higher than LIBs. In LMBs, the cathode can be the conventional cathode materials used in LIBs, or...
Published: 2/13/2025
|
Inventor(s):
Zhaoyang Fan
,
Wenyue Li
,
Shu Wang
Keywords(s):
Category(s):
Biomaterials
,
Physical Science
,
Energy & Power
,
Alternative Energy/Biofuels/Bioplastics/Algae
Zika Virus Vaccines
Zika virus (ZIKV) is a flavivirus transmitted by mosquitos that is strongly linked to neurological complications including Guillain-Barré syndrome, meningoencephalitis, and microcephaly. The association between active ZIKV infection during pregnancy and microcephaly and intrauterine growth retardation in the fetus has been confirmed in murine models...
Published: 8/13/2025
|
Inventor(s):
John Mascola
,
Wing-pui Kong
,
Eun Yang
,
Wei Shi
,
Theodore Pierson
,
Leda Castilho
,
Kimberly Dowd
,
Lingshu Wang
,
Christina Demaso
,
Rebecca Pelc
,
Adrian Creanga
,
Julie Ledgerwood
,
Sebastian Ramesch
,
Barney Graham
Keywords(s):
Chimera
,
DC5BXX
,
GENE-BASED
,
JAPANESE ENCEPHALITIS VIRUS
,
vaccines
,
virus-like particles
,
VLP
,
Zika
Category(s):
Collaboration Sought > Licensing
,
Application > Vaccines
,
TherapeuticArea > Infectious Disease
Multifunctional Edible Nutraceutical Coating
The short shelf life of fresh produce, due in large part to microbial induced spoilage, is a serious problem that is costing the food industry billions a year. Many plants have natural phytochemicals which help confer resistance to microbial infections. Phytochemicals also have health benefits for humans, making them attractive candidates for coating...
Published: 7/16/2025
|
Inventor(s):
Shu Wang
,
Zhaoyang Fan
Keywords(s):
Category(s):
Life Science (All LS Techs)
,
Advanced Materials/Nanotechnology
,
Agriculture/Animal Health
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