Search Results - wan+shih

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Enhanced detection sensitivity with piezoelectric sensors
PAGE TITLEOverviewPAGE SUMMARY A method for enhancing the detection sensitivity of a piezoelectric microcantilever sensor. The method may involve providing a piezoelectric microcantilever and inducing a change in the Young's modulus during detection of a species of interest. The change in the Young's modulus may be induced or enhanced by the application...
Published: 2/19/2025   |   Inventor(s): Wan Shih, Wei-Heng Shih, Qing Zhu
Keywords(s): Ceramic Sensors, In-vitro diagnostics
Category(s): Medical Devices, Diagnostics & Biosensors, Electronics
FLOW-BASED ENHANCEMENT OF SPECIFICITY FOR LABEL-FREE BIOCHEMICAL ASSAYS
PAGE TITLE Overview PAGE SUMMARY A label-free biochemical assay, in which label-free interrogation of a target-receptor layer is performed while the target-receptor layer is subjected to a relatively strong flow of an analyte-containing fluid. The volumetric flow rate for the assay is selected based on calibration data corresponding to the target...
Published: 2/19/2025   |   Inventor(s): Wan Shih, Wei-Heng Shih, John-Paul Mcgovern
Keywords(s):  
Category(s): Medical Devices, Diagnostics & Biosensors, Electronics
Lead-free piezoelectric ceramic films and a method for making thereof
PAGE TITLEOverviewPAGE SUMMARY This invention relates to lead-free piezoelectric ceramic films and a method of making thereof. Specifically, the invention is directed to a method for fabricating lead-free piezoelectric free standing films having enhanced piezoelectric properties. The films may be used for a number of applications including incorporation...
Published: 2/18/2025   |   Inventor(s): Wei-Heng Shih, Wan Shih, Huidong Li
Keywords(s): Ceramic Sensors
Category(s): Medical Devices, Diagnostics & Biosensors, Electronics, Advanced Materials & Chemicals, Biomaterials & Drug Delivery
Specificity and sensitivity enhancement in cantilever sensing
PAGE TITLE Overview PAGE SUMMARY The invention is directed to a sensor system including at least one sensor and target specific receptors bound substrates for purposes of enhancing detection sensitivity. Optionally, the sensor system may include quantum dots for independently verifying the presence of a target molecule or compound. The sensor...
Published: 2/18/2025   |   Inventor(s): Wei-Heng Shih, Wan Shih
Keywords(s):  
Category(s): Medical Devices, Diagnostics & Biosensors, Electronics, Advanced Materials & Chemicals
Non-invasive melanoma thickness measurement
PAGE TITLEOverviewPAGE SUMMARY Melanoma is a malignant tumor of melanocytes, which are melanin-producing cells located predominately in the skin. Melanoma is one of the most aggressive and deadly types of cancer. Approximately 80,000 new cases of invasive melanoma are diagnosed in the United States, and about 10,000 people die of the disease annually....
Published: 2/19/2025   |   Inventor(s): Wan Shih, Wei-Heng Shih, Xin Xu
Keywords(s):  
Category(s): Medical Devices, Diagnostics & Biosensors, Electronics
Rapid Antimicrobial Susceptibility Testing using Piezoelectric Sensor
PAGE TITLE Overview PAGE SUMMARY In the U.S., each year at least 2 million people acquire serious infections with bacteria resistant to one or more of the antibiotics, resulting in >$20 billion in direct healthcare costs and $35 billion in lost productivity. In particular, nosocomial bloodstream infections (BSI’s), including catheter-related...
Published: 2/20/2025   |   Inventor(s): Wan Shih, Wei-Heng Shih, Xin Xu, Christopher Emery, Suresh Joshi, Wei Wu
Keywords(s):  
Category(s): Medical Devices, Diagnostics & Biosensors, Advanced Materials & Chemicals
Piezoelectric Plate Sensor (PEPS)
PAGE TITLE Overview PAGE SUMMARY Improving sensitivity, accuracy and efficiency of piezoelectric sensors for detecting biomolecules is important to the development of sensitive and reliable assays in the healthcare field for early detection and prevention of diseases. To achieve sub-femtomolar sensitivity, Drexel’s researchers have developed...
Published: 2/20/2025   |   Inventor(s): Wan Shih, Wei-Heng Shih, Wei Wu, Mehmet Cagri Soylu, Ceyhun Ekrem Kirimli, Suresh Joshi, Haitao Guo, Ying-Hsiu Su
Keywords(s):  
Category(s): Medical Devices, Diagnostics & Biosensors, Electronics, Advanced Materials & Chemicals
Water-soluble nanoscale quantum dots for imaging and biomedical applications
PAGE TITLEOverviewPAGE SUMMARY Quantum dots (QDs) are inorganic nanoparticles that emit light at a specific wavelength when excited by light. Typically, they are synthesized using multi-step processes and hazardous organic solvents. These organic solvents must be removed prior to conjugating QDs with antibodies and other ligands for use in biological...
Published: 2/19/2025   |   Inventor(s): Wei-Heng Shih, Wan Shih
Keywords(s):  
Category(s): Medical Devices, Diagnostics & Biosensors