Search Results - wei-cheng+lu

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Modified kynureninase enzymes for cancer therapy
This invention describes modified kynureninase enzymes, particularly human enzymes, for degrading kynurenine. These enzymes can be used in compositions and methods for treating cancer by depleting kynurenine levels. Background Cancer immunotherapy has emerged as a promising approach to treating a wide range of malignancies. The goal of immunotherapy...
Published: 11/5/2024   |   Inventor(s): George Georgiou, Everett Stone, John Blazeck, Nicholas Marshall, Wei-Cheng Lu
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Therapeutics > Gene therapy
Enhanced cancer treatment through methionine depletion
The invention involves engineering a modified human cystathionine-γ-lyase enzyme to degrade methionine, an amino acid essential for cancer cell growth. This modified enzyme, with specific amino acid substitutions, offers enhanced catalytic activity, stability, and reduced immunogenicity, making it suitable for cancer treatment by depleting methionine...
Published: 9/13/2024   |   Inventor(s): George Georgiou, Everett Stone, Wei-Cheng Lu
Keywords(s):  
Category(s): Life sciences > Metabolic engineering, Life sciences > Therapeutics > Gene therapy
Engineered enzymes for cystinuria treatment
The invention describes engineered primate cystathionine-gamma-lyase (CGL) enzymes with specific amino acid modifications to efficiently degrade L‑cystine and L-cysteine. These enzymes are designed to treat cystinuria by reducing cystine levels in the body, preventing cystine stone formation. Background Cystinuria is a genetic disorder caused by mutations...
Published: 11/5/2024   |   Inventor(s): Everett Stone, Wei-Cheng Lu, Christos Karamitros
Keywords(s):  
Category(s): Life sciences > Therapeutics > Gene therapy
Enhancing Fairness Through Aleatoric Uncertainty
Background In recent years, advancements in machine learning have revolutionized various domains, but concerns about bias and unfairness in automated decision-making systems have gained significant attention. One of the causes of unfairness in AI systems is the reliance on training data. Aleatoric uncertainty refers to the inherent randomness or variability...
Published: 8/7/2024   |   Inventor(s): Anique Tahir, Lu Cheng, Huan Liu
Keywords(s): Artificial Intelligence, Machine Learning
Category(s): Physical Science, Computing & Information Technology, Intelligence & Security
ONE GRAM PENNY-SIZED WIRELESS EEG RECORDING PATCH FOR LONG-TERM MENTAL HEALTH MONITORING
ONE GRAM PENNY-SIZED WIRELESS EEG RECORDING PATCH FOR LONG-TERM MENTAL HEALTH MONITORING Researchers at Stanford have developed a wearable patch that allows for continuous mental health monitoring via electroencephalogram (EEG) recording. EEG technology was developed during the advent of neuroscience nearly a century and a half ago. EEG technology...
Published: 8/17/2023   |   Inventor(s): Ada Poon, Cheng Chen, Joonseok Yang, Hui Wang
Keywords(s): EEG, Neurology, Wearable
Category(s): Technology Classifications > Engineering
y-AApeptide-based long-acting pan-coronavirus fusion inhibitor with dual targets in spike protein and oral bioavailability
­Advantages: S-20-1 demonstrates potent inhibitory action, this broad-spectrum activity suggests that S-20-1 could be effective against a wide range of coronaviruses, making it a valuable candidate for pandemic preparedness and management. The research provides insights into the mechanism of action of S-20-1, demonstrating its ability to bind...
Published: 9/25/2023   |   Inventor(s): Jianfeng Cai, Shibo JIANG, Lu LU, Songyi XUE, Xinling WANG, Lei WANG, Wei XU, Shuai XIA
Keywords(s): Drug Discovery, Immunology
Category(s): Technology Classifications > Medical > Biotechnology
Novel Multi-Omics Aging Clock
­A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 3/12/2024   |   Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools
Application of the Synchronization Modulation Technique of the Na/k Pumps in Treatment of Muscle Fatigue
­Competitive Advantages Postpones or relieves muscle fatigue Could reduce recovery time in different diseases Reduces ATP consumption thus increases energy for muscle contraction Summary Muscle fatigue is an important public health problem for large population especially for the people with occupations of athlete, soldier, and heavy-duty...
Published: 7/11/2023   |   Inventor(s): Wei Chen, Jason Mast, Pengfei Liang
Keywords(s): Pain Relief / Management, Wound and Tissue Healing
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Chemistry
Autonomous Drone for railroad track inspection
Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...
Published: 3/15/2023   |   Inventor(s): Yu Qian, Yi Wang, Chen Chen
Keywords(s): autonomous drone, flight control, image processing, railroad track inspection, self-navigation
Category(s): Engineering and Physical Sciences
Unsupervised Cyberbullying Detection Via Time-Informed Gaussian Mixture Model
Background Cyberbullying, defined as “aggressively intentional acts carried out by a group or an individual using electronic forms of contact, repeatedly or over time against victims who cannot easily defend themselves,” has been rising at an alarming rate. Previous research has found that nearly 43% of teens in the United States have been...
Published: 2/23/2023   |   Inventor(s): Lu Cheng, Kai Shu, Siqi Wu, Yasin Silva, Deborah Hall, Huan Liu
Keywords(s): Causal Learning, Data Mining, Machine Learning
Category(s): Wireless & Networking, Physical Science, Computing & Information Technology
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