Search Results - christos+karamitros

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Pharmacologically optimized human kynureninase variants for cancer treatment
­The invention describes a modified kynureninase enzyme with enhanced catalytic efficiency and stability for therapeutic applications, particularly in cancer treatment. It depletes kynurenine, aiding cancer therapy alone or with other treatments, and can be PEGylated for increased in vivo half-life. Background Cancer cells often manipulate metabolic...
Published: 11/5/2024   |   Inventor(s): George Georgiou, Everett Stone, John Blazeck, Christos Karamitros
Keywords(s):  
Category(s): Life sciences > Therapeutics > Gene therapy, Life sciences > Research tools > Tool/assay/screening platform
Engineered enzymes for cystinuria treatment
The invention describes engineered primate cystathionine-gamma-lyase (CGL) enzymes with specific amino acid modifications to efficiently degrade L‑cystine and L-cysteine. These enzymes are designed to treat cystinuria by reducing cystine levels in the body, preventing cystine stone formation. Background Cystinuria is a genetic disorder caused by mutations...
Published: 11/5/2024   |   Inventor(s): Everett Stone, Wei-Cheng Lu, Christos Karamitros
Keywords(s):  
Category(s): Life sciences > Therapeutics > Gene therapy