Search Results - george+georgiou

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Antibody and T-cell receptor sequencing for identifying cancer-specific immune receptors
This tech identifies cancer-specific antibodies and T-cell receptors by sequencing mRNA from immune cells in a patient’s tumor-draining lymph nodes and comparing the sequences with the patient’s antibody polypeptide data. Background Cancer immunotherapy has emerged as a promising approach to treating various types of cancers. This field...
Published: 10/22/2024   |   Inventor(s): Gregory Ippolito, Jonathan McDaniel, William Voss, George Georgiou
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Immunology
Modified kynureninase enzymes for cancer therapy
This invention describes modified kynureninase enzymes, particularly human enzymes, for degrading kynurenine. These enzymes can be used in compositions and methods for treating cancer by depleting kynurenine levels. Background Cancer immunotherapy has emerged as a promising approach to treating a wide range of malignancies. The goal of immunotherapy...
Published: 11/5/2024   |   Inventor(s): George Georgiou, Everett Stone, John Blazeck, Nicholas Marshall, Wei-Cheng Lu
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Therapeutics > Gene therapy
Methodology for high-throughput sequencing of paired antibody transcripts from B cells
The technology enables rapid and accurate sequencing of paired VH and VL antibody transcripts from single antigen-specific B cells. It involves isolating B cells, capturing their mRNA and antibodies, forming complexes with affinity agents, purifying these complexes, and performing RT-PCR to generate and sequence cDNA, facilitating various immunological...
Published: 9/16/2024   |   Inventor(s): George Georgiou, Erik Johnson
Keywords(s):  
Category(s): Life sciences > Immunology, Life sciences > Research tools > Tool/assay/screening platform
Biotechnological platform for engineering enzymes to degrade L‑Cyst(e)ine for cancer therapy
The invention involves engineering a modified enzyme, cystathionine-gamma-lyase, to degrade L-cyst(e)ine, targeting cancer cells reliant on this amino acid. The enzyme exhibits improved stability and reduced immunogenicity, making it suitable for therapeutic applications in cancer treatment. Background Cancer cells often exhibit altered metabolic...
Published: 11/5/2024   |   Inventor(s): George Georgiou, Everett Stone
Keywords(s):  
Category(s): Life sciences > Therapeutics > Gene therapy, Life sciences > Research tools > Tool/assay/screening platform
Biotechnological approach for cancer treatment through kynurenine depletion using engineered enzymes​​​​​
This invention describes engineered kynureninase enzymes that degrade kynurenine, a metabolite linked to cancer progression. These enzymes, optimized for human therapy, can be modified with polyethylene glycol to enhance stability and circulation, offering potential in cancer treatment when combined with other therapies like immunotherapy. Background Cancer...
Published: 11/5/2024   |   Inventor(s): George Georgiou, Everett Stone
Keywords(s):  
Category(s): Life sciences > Metabolic engineering, Life sciences > Therapeutics > Gene therapy
Enhanced cancer treatment through methionine depletion
The invention involves engineering a modified human cystathionine-γ-lyase enzyme to degrade methionine, an amino acid essential for cancer cell growth. This modified enzyme, with specific amino acid substitutions, offers enhanced catalytic activity, stability, and reduced immunogenicity, making it suitable for cancer treatment by depleting methionine...
Published: 9/13/2024   |   Inventor(s): George Georgiou, Everett Stone, Wei-Cheng Lu
Keywords(s):  
Category(s): Life sciences > Metabolic engineering, Life sciences > Therapeutics > Gene therapy
Engineered enzymes for enhanced kynurenine degradation in cancer therapy​​
The technology describes a modified human kynureninase enzyme with enhanced catalytic efficiency for degrading kynurenine, achieved through specific amino acid substitutions. This enzyme, used in therapeutic applications, reduces kynurenine levels to mitigate tumor-mediated immune suppression and promote anti-tumor immune responses. Background Cancer...
Published: 11/5/2024   |   Inventor(s): George Georgiou, Everett Stone, John Blazeck
Keywords(s):  
Category(s): Life sciences > Therapeutics > Gene therapy, Life sciences > Research tools > Tool/assay/screening platform
Therapeutic applications of engineered L-Cyst(e)ine-degrading enzymes
The technology describes engineered primate cystathionine-γ-lyase enzymes with specific amino acid modifications that enhance their ability to degrade L-cyst(e)ine. These enzymes, intended for therapeutic use in cancer and cystinuria, improve stability and reduce immunogenicity. Background Cancer and cystinuria present significant therapeutic...
Published: 11/5/2024   |   Inventor(s): George Georgiou, Shira Cramer, Everett Stone
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Therapeutics > Gene therapy
Pharmacologically optimized human kynureninase variants for cancer treatment
­The invention describes a modified kynureninase enzyme with enhanced catalytic efficiency and stability for therapeutic applications, particularly in cancer treatment. It depletes kynurenine, aiding cancer therapy alone or with other treatments, and can be PEGylated for increased in vivo half-life. Background Cancer cells often manipulate metabolic...
Published: 11/5/2024   |   Inventor(s): George Georgiou, Everett Stone, John Blazeck, Christos Karamitros
Keywords(s):  
Category(s): Life sciences > Therapeutics > Gene therapy, Life sciences > Research tools > Tool/assay/screening platform
Advanced techniques for generating antigen-specific antibodies
Background Biotechnology has advanced in the development and application of antibodies for therapeutic, diagnostic, and research purposes. Antibodies are crucial for their ability to specifically bind to antigens, making them valuable tools in the treatment of diseases, including cancer, autoimmune disorders, and infectious diseases. However, the identification...
Published: 7/16/2024   |   Inventor(s): George Georgiou, Edward Marcotte, Daniel Boutz, Yariv Wine, Jason Lavinder
Keywords(s):  
Category(s): Life sciences > Immunology > Genomics/genetics, Life sciences > Research tools > Tool/assay/screening platform
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