Search Results - roger+taylor

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Strategies to Detect, Prevent and Reverse Acquired Resistance to Immune Checkpoint Blockade Therapy (UCLA Case No. 2024-085)
UCLA researchers in the Department of Medicine have uncovered novel mechanism of acquired resistance against immune checkpoint blockade therapy in melanoma patients. BACKGROUND: Immune checkpoint blockade (ICB) therapy is a type of cancer immunotherapy that targets immune system components in order to reactivate immune cells to combat tumor cells....
Published: 5/8/2024   |   Inventor(s): Roger Lo
Keywords(s): acquired resistance, Apoptosis, Cancer, Cancer Immunotherapy, Immune checkpoint blockade, Immunotherapy, Melanoma, T Cell
Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy
2022-077 Methods to Enhance Cancer Immune Surveillance and Therapeutic Efficacy in Melanoma by Control of Cancer Cell-Surface PD-L1/L2 and the E3 Ligase Itch
SUMMARY: UCLA researchers in the Department of Medicine have discovered an enzyme that downregulates tumor expression levels of PD-L1/L2 in MAPKi-resistant melanoma with the potential to enhance cancer immune surveillance and therapeutic efficacy in drug-resistant melanoma. TITLE: Methods to enhance cancer immune surveillance and therapeutic efficacy...
Published: 9/7/2023   |   Inventor(s): Roger Lo
Keywords(s):  
Category(s): Therapeutics, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy
2022-021 Methods to Enhance the Efficacy of Combined Targeting of Immune Checkpoint and MAPK Pathways
SUMMARY: Researchers from UCLA’s David Geffen School of Medicine have discovered a novel regimen using MAPK inhibition and immune checkpoint therapy for the treatment of melanoma and other cancers. Furthermore, they have outlined cellular targets in the tumor microenvironment with key roles in improving sensitivity to therapy. BACKGROUND: Programmed...
Published: 7/19/2023   |   Inventor(s): Roger Lo
Keywords(s):  
Category(s): Therapeutics, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy
Automated Microscopic Image Acquisition, Compositing and Display Software Developed for Applied Microscopy/Cytology Training and Analysis
Micro-Screen is a CDC developed software program designed to capture images and archive and display a compiled image(s) from a portion of a microscope slide in real time. This program allows for the re-creation of larger images that are constructed from individual microscopic fields captured in up to five focal planes and two magnifications. This program...
Published: 7/25/2024   |   Inventor(s): Roger Taylor, James Lange, Tommy Lee, Carlyn Collins, MariBeth Gagnon
Keywords(s): AA3AXX, AA3B6X, AA3CXX, AA3XXX, AC2XXX, AC3XXX, Acquisition, ACXXXX, AD2XXX, AD3XXX, ADXXXX, Automated, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositing, DISPLAY, Image, MICROSCOPIC, OID-NCPDCID-DLS, VAXXXX, VBXXXX, VCXXXX, VDXXXX, VEXXXX, VFXXXX, VGXXXX, VHXXXX, VIXXXX, VJXXXX, VKXXXX, VLXXXX, VMXXXX, VNXXXX, VOXXXX, VPXXXX, WBXXXX, WIXXXX, WMXXXX, XDXXXX, XFXXXX, XHXXXX, XJXXXX, YBXXXX, YEXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Psychiatry/Mental Health, Application > Consumer Products, TherapeuticArea > Neurology, TherapeuticArea > Oncology, ResearchProducts > Computational models/software, TherapeuticArea > Cardiology, TherapeuticArea > Dental, Application > Medical Devices, TherapeuticArea > Geriatrics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Immunology, TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, Application > Non-Medical Devices, TherapeuticArea > Infectious Disease, Application > Software / Apps, Application > Research Materials, ResearchProducts > Research Equipment, Application > Diagnostics
2022-187 Blocking Chromothriptic Genomic Instability to Prevent the Evolution of MAPK Inhibitor Resistance in Melanoma
SUMMARY: UCLA researchers in the Department of Medicine have developed a novel therapeutic method to prevent acquired resistance to MAPK drug inhibition in melanoma. BACKGROUND:Melanoma is the fifth most common cancer in the United States and the most fatal of all skin cancer types. Typical treatments of melanoma tumors include pharmacological drugs...
Published: 9/7/2023   |   Inventor(s): Roger Lo
Keywords(s):  
Category(s): Therapeutics, Therapeutics > Oncology
Methods for Predicting Response Patterns to Anti-PD-1 Therapy in Metastatic Melanoma (UCLA Case No. 2016-582)
SUMMARYDr. Roger Lo and colleagues in the Department of Medicine at UCLA have identified a method to predict a melanoma patient’s resistance to pembrolizumab and other immune checkpoint inhibitors.BACKGROUNDImmune checkpoint inhibitors are the most recent stars in cancer therapeutics: the first 4+ drugs in the category have received breakthrough...
Published: 2/14/2024   |   Inventor(s): Roger Lo, Antoni Ribas, Willy Hugo, Jesse Zaretsky
Keywords(s):  
Category(s): Diagnostic Markers, Therapeutics > Oncology > Oncology Immunotherapy