Search Results - v+kalyanaraman

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nsP2 Inhibitors: Targeting the Alphavirus nsP2 Protease
This invention relates to antiviral compounds targeting the alphavirus nsP2 protease, pharmaceutical compositions, and methods of use for the prevention, treatment, or mitigation of the Chikungunya virus. This compound selectively interferes with the essential proteolytic processing activity of nsP2, a critical step in the viral life cycle. By blocking...
Published: 4/29/2026   |   Updated: 4/29/2026   |   Inventor(s): Hongmin Li, Rui Xiong, Subodh Samrat, Malla Reddy Gannarapu, Ran Zhang, Ke Chen, Mengjiao Ma, Omar Alejandro Lozano Ramos, Divakar Indukuri, Renu Bhardwaj
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules
Autonomous Smart Buildings with AI and Blockchain
THE CHALLENGE Modern buildings operate at the intersection of rising operational costs, complex stakeholder demands, and increasing expectations for energy efficiency and user experience, yet most current solutions fall short of delivering a viable business model for true autonomy. Centralized building management systems often function as opaque control...
Published: 3/26/2026   |   Updated: 3/26/2026   |   Inventor(s): Alireza Shojaei, Reachsak Ly
Keywords(s):  
Category(s): Technology Classifications > Architecture/Building, Technology Classifications > Computer Science
AI-Powered Smart Building Management
THE CHALLENGE Modern smart building solutions face a critical operational bottleneck due to their reliance on rigid, rule-based automation and cloud-dependent AI platforms. These systems often struggle to adapt to changing environmental conditions or complex occupant behaviors, resulting in inefficiencies in energy management, comfort optimization,...
Published: 3/26/2026   |   Updated: 3/26/2026   |   Inventor(s): Alireza Shojaei, Reachsak Ly
Keywords(s):  
Category(s): Technology Classifications > Computer Science, Technology Classifications > Architecture/Building
Silk-Chromophore Composite Materials for In Situ Oxygen Sensing
Silk-based Materials for Oxygen Sensing (T002586) Background Monitoring tissue oxygenation in vivo is critical for wound healing, organ transplants, and oncology. However, current sensors face two major hurdles: Most sensors require secondary surgery for removal, increasing patient risk and healthcare costs. Traditional materials can trigger...
Published: 3/13/2026   |   Updated: 3/13/2026   |   Inventor(s): David Kaplan, Thomas Falcucci, Kayla Presley, Jack Ly, Matthew Dalton, Tod Grusenmeyer
Keywords(s):  
Category(s): Device, Diagnostic, Nanotechnology: sensors
System For Applying Therapy To the Human Body
RPI ID: 2022-038-201 Innovation Summary: A therapeutic system is disclosed that includes a coupling apparatus and a supporting apparatus designed to apply spinal traction while the user is in a seated position. The coupling apparatus attaches to the upper body using components such as a vest, belt, or harness, while the supporting apparatus—such...
Published: 3/10/2026   |   Updated: 3/10/2026   |   Inventor(s): Michael Castello, Ryan Chien, Jeongwon Choi, Ruiqi Ma, Jacqueline Ray, Eric Ledet
Keywords(s):  
Category(s): Nanotechnology and Advanced Materials
Task-Oriented Deep Learning Image Denoising
RPI ID: 2022-015-201 Innovation Summary: A deep learning-based image denoising method tailored to specific tasks such as segmentation or classification. Unlike generic denoising, it preserves features critical to downstream analysis. The model adapts its strategy based on the intended application, improving performance in real-world scenarios. It is...
Published: 3/10/2026   |   Updated: 3/10/2026   |   Inventor(s): Jiajin Zhang, Hanqing Chao, Ge Wang, Pingkun Yan
Keywords(s): Artificial Intelligence, deep learning, Image Denoising, image quality, medical imaging
Category(s): Computational Science and Engineering
End-to-end machine learning based multi-modal multi-dimensional image registration
RPI ID: 2021-050-201 Innovation Summary: This system performs multi-modal, multi-dimensional image registration using a hybrid approach that combines spatial mapping and intensity-based alignment. It supports registration across imaging modalities such as MRI, CT, and PET. The method improves accuracy in anatomical and functional image fusion. It is...
Published: 3/10/2026   |   Updated: 3/10/2026   |   Inventor(s): Hengtao Guo, Xuanang Xu, Xinrui Song, Pingkun Yan
Keywords(s): Artificial Intelligence, deep neural networks, image fusion, medical image registration, medical image-guided intervention
Category(s): Biotechnology and the Life Sciences
System and methods for machine learning based trackingless volume reconstruction
RPI ID: 2020-060-201 Innovation Summary: A machine learning system reconstructs imaging volumes without requiring external tracking devices. The method uses internal image features and learned spatial relationships to align and assemble slices into coherent 3D volumes. It is particularly useful in ultrasound and other modalities where tracking hardware...
Published: 3/10/2026   |   Updated: 3/10/2026   |   Inventor(s): Hengtao Guo, Pingkun Yan
Keywords(s): deep learning, image reconstruction, medical imaging
Category(s): Biotechnology and the Life Sciences
Trackerless 2D Ultrasound frames to 3D image volume registration
RPI ID: 2020-025-401 Innovation Summary: A system and method are introduced for registering 2D ultrasound frames into a 3D image volume without the need for external tracking hardware. The approach uses internal image features and spatial inference to align slices, enabling coherent volume reconstruction. It is particularly suited for portable and...
Published: 3/10/2026   |   Updated: 3/10/2026   |   Inventor(s): Pingkun Yan
Keywords(s): image analysis, image-guided intervention, medical imaging
Category(s): Biotechnology and the Life Sciences
Patient-Specific Organ Dose Quantification and Optimization for CT
RPI ID: 2020-032-401 Innovation Summary: A computational method enables quantification of organ-specific radiation dose during CT imaging and uses inverse optimization to adjust scan parameters accordingly. The system incorporates patient-specific anatomical models and dose-response data to guide personalized imaging protocols. It supports real-time...
Published: 3/10/2026   |   Updated: 3/10/2026   |   Inventor(s): Pingkun Yan, Birsen Yazici, Xie Xu
Keywords(s): AI workflow, Artificial Intelligence Radiology, Clinical Imaging, computed tomography (CT), CT dosimetry, CT Scanner, deep learning, Dosimetry, Imaging, medical imaging, Nuclear Medicine, Personalized Medicine, Radiology, X-Rays
Category(s): Biotechnology and the Life Sciences
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