Search Results - subodh+samrat

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nsP2 Inhibitors: Targeting the Alphavirus nsP2 Protease
This invention relates to antiviral compounds targeting the alphavirus nsP2 protease, pharmaceutical compositions, and methods of use for the prevention, treatment, or mitigation of the Chikungunya virus. This compound selectively interferes with the essential proteolytic processing activity of nsP2, a critical step in the viral life cycle. By blocking...
Published: 4/29/2026   |   Updated: 4/29/2026   |   Inventor(s): Hongmin Li, Rui Xiong, Subodh Samrat, Malla Reddy Gannarapu, Ran Zhang, Ke Chen, Mengjiao Ma, Omar Alejandro Lozano Ramos, Divakar Indukuri, Renu Bhardwaj
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Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules
Allosteric Inhibitors of the Main Protease of SARS-CoV-2
In this report, the SARS-CoV-2 3CLpro was expressed and purified. By using a FRET-based enzymatic assay, the researchers have screened a library consisting of more than 300 different niclosamide derivatives and identified three molecules JMX0286, JMX0301, and JMX0941 as potent allosteric inhibitors against SARS-CoV-2 3CLpro, with IC50 values like that...
Published: 4/1/2024   |   Updated: 4/5/2023   |   Inventor(s): Hongmin Li, subodh samrat, Zhong Li, Jia Zhou, Jimin Xu
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Infectious Diseases