Search Results - tsanyang+(jake)+liang

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Transgenic Mouse Model for Marfan Syndrome Research
Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...
Published: 12/23/2025   |   Inventor(s): Li Li, Shichao Wu, Jiawei Zhao
Keywords(s):  
Category(s): Technology Category > Research tools, Technology Category > Animal models, Technology Category > Biology, Technology Category > Diagnostic
Multi-parametric Acoustic, Optical and Mechanical Imaging of Cervical Tissue Insufficiencies to Predict Preterm Birth
An enhanced image-guidance system that integrates ultrasound and photoacoustic into existing ablation systems to provide an enhanced image-guidance system for identification of cervical tissue changes during pregnancy and postpartum. Technology Summary Preterm delivery is a main cause of perinatal morbidity and mortality worldwide, which is associated...
Published: 10/1/2025   |   Inventor(s): Mohammad Mehrmohammadi, Sonia Hassan, Edgar Hernandez-Andrade, Yan Yan, Maryam Basij
Keywords(s): Driving Lifelong Health
Category(s): Technology Category > Women's Health, Technology Category > Medical Devices, Technology Category > Life Science, Technology Category > Imaging, Technology Category > Acoustics
An OCT method to improve scleral lens fitting
Summary The current technology allows for accurate and objective 3-dimensional (3D) mapping of the external limbus, which could ultimately improve the process of scleral lens fitting. Technology Overview Rigid scleral lenses are difficult to fit to patients because they must rest on the eye but vault over the cornea and the limbus, which is the transition...
Published: 9/4/2025   |   Inventor(s): David Huang, Yan Li, Clara Llorens Quintana
Keywords(s): Imaging, Imaging - Other, Software, Software - Diagnostic/Detection
Category(s): Imaging, Software
High-Throughput Direct-Measurement of Telomere Length
Telomeres are linear chromosome end-capping repetitive DNA sequences. They serve to protect the ends of chromosomes from undesirable fusion events, thus integrity and length are crucial for stability. Natural attrition as well as mutations can affect telomere integrity and length resulting in chromosome instability, senescence, cell death and human...
Published: 2/13/2025   |   Inventor(s): Julian Chen, Yang Li, Dhenugen Logeswaran
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Medical Diagnostics/Sensors
Learning Sparse Features for Self-Supervised Learning with Contrastive Dual Gating
The success of conventional supervised learning relies on large-scale labeled datasets to achieve high accuracy. However, annotating millions of data samples is labor-intensive and time-consuming. This promotes self-supervised learning as an attractive solution with artificial labels being used instead of human-annotated ones for training. Contrastive...
Published: 2/13/2025   |   Inventor(s): Jae-Sun Seo, Jian Meng, Li Yang, Deliang Fan
Keywords(s): Algorithm Development, Machine Learning, Performance Optimization, PS-Computing and Information Technology
Category(s): Computing & Information Technology, Physical Science
Temperature-Resilient RRAM-Based In-Memory Computing for DNN Inference
Deep neural networks (DNNs) have shown extraordinary performance in recent years for various applications, including image classification, object detection, speech recognition, etc. Accuracy-driven DNN architectures tend to increase model sizes and computations in a very fast pace, demanding a massive amount of hardware resources. Frequent communication...
Published: 2/13/2025   |   Inventor(s): Jae-Sun Seo, Jian Meng, Li Yang, Deliang Fan
Keywords(s): Algorithm Development, Machine Learning, Memory, Neural Computing, PS-Computing and Information Technology
Category(s): Computing & Information Technology, Physical Science
Masked-Based Learning Method for Neural Network Multiple Task Adaption
Nowadays, one practical limitation of deep neural networks (DNNs) is their high degree of specialization to a single task. This motivates researchers to develop algorithms that can adapt the DNN model to multiple tasks sequentially, while still performing well on past tasks. This process of gradually adapting the DNN model to learn from different...
Published: 2/13/2025   |   Inventor(s): Deliang Fan, Fan Zhang, Li Yang
Keywords(s): Algorithm Development, Computational Machine, Computing Architecture, Cyber-Physical System, Machine Learning, Neural Computing
Category(s): Computing & Information Technology, Physical Science
Memory Efficient, Multi-Domain On-Device Machine Learning
­One practical limitation of deep neural network (DNN) is its high degree of specialization to a single task or domain (e.g., one visual domain). This motivates the development of algorithms that can adapt DNN model to multiple domains sequentially while still performing well on past domains. This is known as multi-domain learning. Conventional...
Published: 2/13/2025   |   Inventor(s): Li Yang, Deliang Fan, Adnan Siraj Rakin
Keywords(s): Algorithm Development, Artificial Intelligence, Machine Learning, On-device learning, PS-Computing and Information Technology
Category(s): Physical Science, Computing & Information Technology
Heterocyclic Compounds for the Treatment of Hepatitis C Virus
The vast majority of people infected with Hepatitis C Virus (HCV) will have chronic infection. Over decades, this can lead to liver disease and liver cancer. In fact, HCV infection is the leading cause of liver transplants in the U.S. Several new drugs have recently come into the market that have changed the HCV treatment paradigm. However, the...
Published: 10/28/2024   |   Inventor(s): Zongyi Hu, Juan Marugan, Noel Southall, Xin Hu, Jingbo Xiao, Shanshan (Melissa) He, Marc Ferrer-Alegre, Wei Zheng, Kevin Frankowski, Frank Schoenen, Kelin Li, Tsanyang (Jake) Liang
Keywords(s): C, Class, compounds, DB4BXX, Development, Hepatitis, Novel, treatment, VLXXXX, WKXXXX, YAXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease
Use of Antihistamine Compounds for the Treatment of Hepatitis C Virus
The vast majority of people infected with Hepatitis C Virus (HCV) will have chronic infection. Over decades, this can lead to liver disease and liver cancer. In fact, HCV infection is the leading cause of liver transplants in the U.S. Several new drugs have recently come into the market that will likely change the HCV treatment paradigm. However,...
Published: 8/13/2025   |   Inventor(s): Wei Zheng, Shanshan (Melissa) He, Zongyi Hu, Tsanyang (Jake) Liang
Keywords(s): Analogs, C, Chlorcyclizine, DB4BXX, Hepatitis, RELATED, treatment, VLXXXX, WKXXXX, YAXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease
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