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Transgenic Mice Overexpressing Islet Beta Cell M3 Muscarinic Acetylcholine Receptors
Researchers at NIH have generated transgenic mice in which the M3 muscarinic receptor is overexpressed in pancreatic beta cells. This was done by placing the receptor gene under the control of the 650 bp rat insulin promoter II (RIP II). The resulting mice show a pronounced increase in glucose tolerance and enhanced plasma insulin levels. Strikingly,...
Published: 10/28/2024   |   Inventor(s): Jurgen Wess
Keywords(s): ACETYLCHOLINE, Beta, Cell, IDXXXX, ISLET, IXXXXX, M3, Mice, MUSCARINIC, Overexpressing, RECEPTORS, TRANSGENIC
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Diagnostics, Application > Research Materials