Search Results - techpub+algolia+%3e+research+tools

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IgG-Specific Enzymes with Reduced Residual Glycan Hydrolysis
Application Novel enzymes for IgG-specific glycosynthesis. Key Benefits Nearly full glycosylation of IgG antibodies. Improved antibody-mediated effector function properties. No measurable residual hydrolysis activity. Market Summary The global monoclonal antibodies market is experiencing significant growth due to the rising prevalence of chronic...
Published: 4/3/2025   |   Inventor(s): Eric J. Sundberg, Jonathan Du, Tala Azzam
Keywords(s): Antibodies, Cardiovascular Treatments, Immunology and Inflammation Treatments, Oncology Treatments
Category(s): TechPub Algolia > Research Tools
A 3D In Vitro Model of the Human Locus Coeruleus
Application A brain organoid model for the human locus coeruleus to study its function and dysfunction in neurological diseases. Key Benefits Locus coeruleus region-specific neural organoid model for studying this deep region of the human brain. The organoid synthesizes norepinephrine, allowing for study of diseases related to these neurotransmitters. The...
Published: 3/6/2025   |   Inventor(s): Fikri Birey, David Weinshenker
Keywords(s): 3D in vitro Models, Neurology and Pain Treatments
Category(s): TechPub Algolia > Research Tools
A GALT-null Rat Model for Studies of Classic Galactosemia
Application Pre-clinical rodent model to study classic galactosemia disease. Key Benefits Identify striking differences in GALT-independent galactose metabolism among tissues and across post-natal time points. Study the relationship between galactose metabolite levels in blood and other tissues. Study the impact of rigorous galactose restriction...
Published: 2/13/2025   |   Inventor(s): Judith Fridovich-Keil
Keywords(s): Animal Model, Rare and Orphan Disease Treatments
Category(s): TechPub Algolia > Research Tools
Anti-Green Fluorescent Protein Antibodies
Applications Western Blot Immunocytochemistry Immunohistochemistry Specificity Vertebrates Subtype Chicken Polyclonal Immunogen His-tagged green fluorescent protein of the bioluminescent hydrozoan jellyfish (Aequorea Victoria). Technical Summary Drs. Tomasiewicz, Wood, & Flaherty have created a polyclonal anti- green fluorescent...
Published: 2/13/2025   |   Inventor(s): Henry Tomasiewicz, John Wood, Denise Flaherty
Keywords(s): Antibodies
Category(s): TechPub Algolia > Research Tools
Optimizing the Engineering of CAR-T Cells
Application A method for selecting distinct T cell populations in order to generate more effective CAR-T cells. Key Benefits The proposed invention focuses on selecting the optimal “starting material” for the engineering CAR-T cells. This selection method can be utilized for the development of any and all CAR-T therapies, not limited...
Published: 2/13/2025   |   Inventor(s): Byron Au-Yeung
Keywords(s): Cell Therapy, Oncology Treatments, Production Methods
Category(s): TechPub Algolia > Research Tools, TechPub Algolia > Therapeutics
Questionnaires for Assessing the Effect of Visual Impairment on Quality of Life and Function in Children
Application A standardized series of questions for the assessment of vision related quality of life and visual function in children and adolescents. Key Benefits Provides age-appropriate questions for children from ages 8-18 as an improvement to using currently available assessments geared toward adults. Allows the subjective assessment of the...
Published: 2/13/2025   |   Inventor(s): Sheila Angeles-Han
Keywords(s): Ophthalmology Treatments, Pediatrics, Surveys and Screening Tools
Category(s): TechPub Algolia > Research Tools
Mouse Model for Specific Proteomic Labeling
Application Proteomic labeling (labeling of proteins). Key Benefits Method can be used to express TurboID in any cell type. The mouse line can be crossed with any existing Cre line and can be extended to any organ/tissue system. Detection of labeled biomarkers can be identified in biofluids as biomarkers of cell specific disease mechanisms. Can...
Published: 2/13/2025   |   Inventor(s): Srikant Rangaraju, Nicholas (Nick) Seyfried, Sruti Rayaprolu
Keywords(s): Animal Model, Biomarkers
Category(s): TechPub Algolia > Research Tools
Human Brain Proteins with Evidence Consistent with Causality of Alzheimer’s and Depression
Application Research and therapeutic targets for Alzheimer’s disease, depression, and other neurological conditions mediated by protein expression in the brain. Key Benefits These findings can be utilized as a research tool to better understand the genetic basis of Alzheimer’s disease. Can also be utilized to develop therapeutics for...
Published: 2/13/2025   |   Inventor(s): Aliza Wingo, Thomas Wingo, Yue Liu, Allan Levey, Nicholas (Nick) Seyfried, Duc Duong
Keywords(s): Drug Target Identification
Category(s): TechPub Algolia > Research Tools, TechPub Algolia > Therapeutics
Pig Lentiviral-Induced Spinal Cord Glioblastoma
Application Porcine model of spinal cord glioblastoma for the development and testing of pre-clinical therapeutic for spinal cord tumors. Key Benefits Novel lentiviral gene transfer offers a viable pathway to modeling glioblastoma in higher order species. The existing model is the first reproducible immunocompetent large animal model of spinal...
Published: 2/13/2025   |   Inventor(s): Muhibullah (Mohib) Tora, Pavlos Texakalidis, Thais Buchman, Nicholas Boulis
Keywords(s): Animal Model
Category(s): TechPub Algolia > Research Tools
Tension-activated Cell Tagging (TaCT)
Application A tool that measures cellular mechanical forces using flow cytometry. Key Benefits A fluorescently labeled approach based on the magnitude of molecular forces transmitted through cell adhesion receptors for evaluating mechanical forces in cells. A prototype has been developed showing proof -of-concept via the ability to determine mechanical...
Published: 3/28/2025   |   Inventor(s): Rong Ma, Khalid Salaita
Keywords(s): Screening Assays
Category(s): TechPub Algolia > Research Tools
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