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Protein Function Scanning by Mass Spectrometry
High throughput, highly controlled mutagenesis method to study protein function of full-length proteins for protein engineering and testing, drug and antibody development, protein interaction and binding studies. Problem: Understanding a protein's functions requires studying each mutation separately through separation-of-function mutations. Traditional...
Published: 12/19/2024   |   Inventor(s): Roberto Bonasio, Julia Tasca
Keywords(s): Bioengineering, Platform Technology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
Bilayer Solid-State Nanopores for the Tracking, Filtering and Guiding of DNA
A bilayered solid-state nanopore material that senses and guides DNA and other biomolecules into homogeneous configurations. Problem: Current methods of DNA sensing and sequencing typically involve short read lengths, chemical labeling, labor-intensive sample preparation, and lack of portability. To minimize these issues during DNA sequencing, protein-based...
Published: 11/25/2024   |   Inventor(s): Marija Drndic, Yung-Chien Chou, Dimitrios Monos, Chih-Yuan Lin
Keywords(s): Nanotechnology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents
Contactless, Reversible Material Deposition From Liquid Droplets To Solid Surfaces
A microfluidic device allowing spatiotemporal manipulation of droplets that can be applied to high-resolution analytical techniques. Problem: Electrowetting methods such as electrowetting-on-dielectric (EWOD) have been developed to support high-resolution analytical techniques such as mass spectrometry and atomic force microscopy. EWOD allows processing...
Published: 10/17/2024   |   Inventor(s): Daeyeon Lee, Junhyong Kim, Paradorn Rummaneethorn
Keywords(s): Microfluidics
Category(s): Technology Classifications > Research Tools & Reagents
Photoactivated Selective Release (PHASR) of Droplets from Microwell Arrays
A photoresponsive polymer layer that can be integrated into microfluidic devices for selective release of unique droplets Problem: Droplet microfluidics are used for single molecule detection and analysis, such as isolation of protein biomarkers for monitoring of disease progression. Current techniques for recovering unique molecules or cells from droplet...
Published: 8/2/2024   |   Inventor(s): Daeyeon Lee, Junhyong Kim, Yongwon Choi, Syung-Hun Han
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Microfluidics, Nanotechnology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents
Fluorescent Probes for the Selective Detection of Alzheimer's and Parkinson's Diseases
Bimane-based fluorescent probes with turn-on fluorescence in the presence of α-synuclein, a known hallmark of Altzeimer’s and Parkinson’s diseases. Problem: Small fluorogenic probes with high sensitivity and selectivity are powerful tools for studying the accumulation of amyloid fibrils in cells or tissue samples from patients with...
Published: 6/27/2024   |   Inventor(s): E. James Petersson, Venkatesh Yarra
Keywords(s):  
Category(s): Technology Classifications > Research Tools & Reagents
Low Cost, Mobile, Wearable EEG Device with High Quality Nanowire Sensors
Mobile, wearable, low cost electro-encephalogram (EEG) devices that offer research grade signals may provide a wealth of information regarding the brain states of individuals. This knowledge can be effectively utilized to develop personalized treatment protocols in medicine and individual customer–based advertisements for marketing. The inventors...
Published: 6/26/2024   |   Inventor(s): Michael Platt, Arjun Ramakrishnan, Naz Belkaya
Keywords(s):  
Category(s): Technology Classifications > Business Ideas, Technology Classifications > Diagnostics, Technology Classifications > Medical Devices, Technology Classifications > Research Tools & Reagents, Technology Classifications > Hardware & Components
High-Throughput and Independent Temperature Regulation In Biological Samples
A device that provides independent thermal regulation for biological samples in a 96-well microwell plate. Problem: Thermal control of cellular processes allows for remote control through tissue or opaque media, allowing for precise targeting of therapies in the body as well as broad control of metabolic processes in bioreactors. However, current...
Published: 6/6/2024   |   Inventor(s): Lukasz Bugaj, Brian Chow, William Benman, Zikang (Dennis) Huang
Keywords(s): Bioengineering, Platform Technology
Category(s): Technology Classifications > Hardware & Components, Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
Biodegradable Batteries Operational In The Air, Environment, And Soil
A method to fabricate batteries from biodegradable materials that can operate in the environment, such as on or under soil, and are scalable in size. Problem: Recently there have been significant developments in biodegradable sensors, which can perform environmental measurements (e.g., on or below the surface of soil) for a specific time and then...
Published: 5/20/2024   |   Inventor(s): Jingwen Zhang, Mark Allen
Keywords(s): Electronic Materials, Hydrogels, Internet of Things, Nanotechnology, Soft Materials
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Agriculture & Environment, Technology Classifications > Energy, Technology Classifications > Materials
Ultrasensitive, High-Throughput, Single-Scale Detection of Extracellular Vesicles
An optofluidic platform to detect extracellular vesicles (EVs) at the single-particle level by parallelizing droplet generation and analysis of EVs. Problem: Extracellular vesicles (EVs) are lipid bound nanomaterials carrying various molecular cargo that can be representative of their cells of origin. EVs play a critical role in intercellular communication...
Published: 2/26/2024   |   Inventor(s): David Issadore, Zijian Yang
Keywords(s): Bioengineering, Microfluidics, Optics & Photonics , Platform Technology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
Base Metal Catalysts For Cyclic Conjugated Polymer Formation
A class of base metal catalysts (as opposed to expensive platinum and heavier group metals) with facile preparation methods for cyclic conjugated polymer synthesis. Problem: There is a demand for facile synthesis and purification of cyclic conjugated polymers due to their applications as lubricants, conductors, or materials with high refractive indices....
Published: 1/29/2024   |   Inventor(s): Daniel Mindiola, John Russell
Keywords(s): Soft Materials
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents
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