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Photoactivated Selective Release (PHASR) of Droplets from Microwell Arrays
A photoresponsive polymer layer that can be integrated into microfluidic devices for selective release of unique droplets Problem: Droplet microfluidics are used for single molecule detection and analysis, such as isolation of protein biomarkers for monitoring of disease progression. Current techniques for recovering unique molecules or cells from droplet...
Published: 8/2/2024   |   Inventor(s): Daeyeon Lee, Junhyong Kim, Yongwon Choi, Syung-Hun Han
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Microfluidics, Nanotechnology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents
Fluorescent Probes for the Selective Detection of Alzheimer's and Parkinson's Diseases
Bimane-based fluorescent probes with turn-on fluorescence in the presence of α-synuclein, a known hallmark of Altzeimer’s and Parkinson’s diseases. Problem: Small fluorogenic probes with high sensitivity and selectivity are powerful tools for studying the accumulation of amyloid fibrils in cells or tissue samples from patients with...
Published: 6/27/2024   |   Inventor(s): E. James Petersson, Venkatesh Yarra
Keywords(s):  
Category(s): Technology Classifications > Research Tools & Reagents
Low Cost, Mobile, Wearable EEG Device with High Quality Nanowire Sensors
Mobile, wearable, low cost electro-encephalogram (EEG) devices that offer research grade signals may provide a wealth of information regarding the brain states of individuals. This knowledge can be effectively utilized to develop personalized treatment protocols in medicine and individual customer–based advertisements for marketing. The inventors...
Published: 6/26/2024   |   Inventor(s): Michael Platt, Arjun Ramakrishnan, Naz Belkaya
Keywords(s):  
Category(s): Technology Classifications > Business Ideas, Technology Classifications > Diagnostics, Technology Classifications > Medical Devices, Technology Classifications > Research Tools & Reagents, Technology Classifications > Hardware & Components
High-Throughput and Independent Temperature Regulation In Biological Samples
A device that provides independent thermal regulation for biological samples in a 96-well microwell plate. Problem: Thermal control of cellular processes allows for remote control through tissue or opaque media, allowing for precise targeting of therapies in the body as well as broad control of metabolic processes in bioreactors. However, current...
Published: 6/6/2024   |   Inventor(s): Lukasz Bugaj, Brian Chow, William Benman, Zikang (Dennis) Huang
Keywords(s): Bioengineering, Platform Technology
Category(s): Technology Classifications > Hardware & Components, Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
Biodegradable Batteries Operational In The Air, Environment, And Soil
A method to fabricate batteries from biodegradable materials that can operate in the environment, such as on or under soil, and are scalable in size. Problem: Recently there have been significant developments in biodegradable sensors, which can perform environmental measurements (e.g., on or below the surface of soil) for a specific time and then...
Published: 5/20/2024   |   Inventor(s): Jingwen Zhang, Mark Allen
Keywords(s): Electronic Materials, Hydrogels, Internet of Things, Nanotechnology, Soft Materials
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Agriculture & Environment, Technology Classifications > Energy, Technology Classifications > Materials
Ultrasensitive, High-Throughput, Single-Scale Detection of Extracellular Vesicles
An optofluidic platform to detect extracellular vesicles (EVs) at the single-particle level by parallelizing droplet generation and analysis of EVs. Problem: Extracellular vesicles (EVs) are lipid bound nanomaterials carrying various molecular cargo that can be representative of their cells of origin. EVs play a critical role in intercellular communication...
Published: 2/26/2024   |   Inventor(s): David Issadore, Zijian Yang
Keywords(s): Bioengineering, Microfluidics, Optics & Photonics , Platform Technology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
Base Metal Catalysts For Cyclic Conjugated Polymer Formation
A class of base metal catalysts (as opposed to expensive platinum and heavier group metals) with facile preparation methods for cyclic conjugated polymer synthesis. Problem: There is a demand for facile synthesis and purification of cyclic conjugated polymers due to their applications as lubricants, conductors, or materials with high refractive indices....
Published: 1/29/2024   |   Inventor(s): Daniel Mindiola, John Russell
Keywords(s): Soft Materials
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents
PET Radiotracers for Diagnosis and Patient Stratification of Neurodegenerative Disorders
Small molecules that bind to alpha-synuclein deposition and can be used for PET imagining in patients with synucleinopathies Problem: Imaging alpha-synuclein (αS) using noninvasive techniques such as positron emission tomography (PET) can help with the early diagnosis of synucleinopathies. Previous PET radiotracers suffer from low binding affinity...
Published: 6/6/2024   |   Inventor(s): Robert Mach, E. James Petersson
Keywords(s): Imaging Agents, Neurodegenerative Diseases, Radiology, Small Molecule
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Diagnostics, Technology Classifications > Imaging, Technology Classifications > Research Tools & Reagents
Revolutionizing CT Imaging: Gold Nanoparticles with Biodegradable Polymer Encapsulation
Innovative CT contrast agent using biodegradable polymer-encapsulated gold nanoparticles for enhanced imaging and safe excretion. Problem: Gold particles emerged as promising contrasting agents due to their high X-ray attenuation, but their size-dependent behavior posed a challenge. Particles larger than 5nm raised toxicity concerns due to potential...
Published: 2/12/2024   |   Inventor(s): David Cormode
Keywords(s):  
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Imaging, Technology Classifications > Research Tools & Reagents
Stable Biological Membrane Mimetic For Enhanced Protein Recruitment
Synthetic biological alternative to natural lipids for conjugation with nitrilotriacetic acid (NTA) for enhanced His-tagged protein interaction and long-term stability. Problem: Biomimetic lipid vesicles, such as liposomes, have multiple biotechnology and drug delivery applications as their lipid bilayer innately interacts with natural cell membranes....
Published: 10/16/2023   |   Inventor(s): Virgil Percec, Qi Xiao, Matthew Good
Keywords(s): Bioengineering, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents
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