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Comprehensive Quantification of Animal Behavior at Ultra-High Resolution
Advantages: Behavior is the ultimate readout of nervous system function. We have developed a method for monitoring movement as well as the principal effectors of behavior, muscles, at unprecedented scale and resolution. Our approach is poised for widespread adoption and will enable new breakthroughs in both clinical and basic research. Problem: Behavioral...
Published: 8/11/2025   |   Inventor(s): Timothy Machado, Jeffrey Gauthier, Michael Economo, Kate Hong
Keywords(s): Neurology, Optics & Photonics , Platform Technology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
Bioengineered Models of Lung Development
Brief Description: A lung-on-a-chip microfluidic chip, comprising: a first region, the first region comprising a central channel and at least one side channel adjacent thereto, the central channel having therein a plurality of cells disposed in a matrix; and a second region, the second region comprising a vacuum chamber; and a membrane disposed between...
Published: 7/9/2025   |   Inventor(s): Dongeun (dan) Huh, Sunghee Estelle Park
Keywords(s): Bioengineering
Category(s): Technology Classifications > Research Tools & Reagents
Methods for Rapid, Scalable, Amplified Nucleic Acid Detection In Situ
Brief Description: The present invention provides novel methods for exponential amplification of nucleic acid's fluorescence in situ hybridization (FISH) signal with high sensitivity and specificity. The present method thereby allows for FISH to be used in high-throughput screening methods and diagnostics. In one aspect, the invention comprises...
Published: 7/9/2025   |   Inventor(s): Arjun Raj, Ian Dardani, Benjamin Emert, Sara Rouhanifard
Keywords(s):  
Category(s): Technology Classifications > Research Tools & Reagents
Intranasal Dantrolene Nanoparticle Use For Treatment Of Alzheimer's Disease
Intranasal delivering of dantrolene nanoparticles could potentially be used to inhibit memory loss and reduce amyloid plaques in patients with Alzheimer's disease. Problem: Alzheimer’s disease (AD) is a devastating neurodegenerative disease. The deficit in the development of new drugs targeting the amyloid pathology over the past several...
Published: 8/1/2025   |   Inventor(s): Huafeng Wei, Qing Cheng Meng, Ge Liang, Maryellen Eckenhoff
Keywords(s): Aging, COVID-19, Nanotechnology, Neurodegenerative Diseases
Category(s): Technology Classifications > Animal Health, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Food Science and Nutrition, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Quick, Scalable, and Precise Method to Produce Uniform Superparticles for Optical and Magnetic Applications
A method to cluster nanocrystals into uniform superparticles using a source-sink emulsion system. Problem: Superparticles present a compelling platform for customizable microscale magnets, sensors, and lasers. However, current manufacturing processes are slow, expensive, and imprecise resulting in loosely packed and polydisperse superparticles. Existing...
Published: 1/28/2025   |   Inventor(s): Emanuele Marino, Sjoerd van Dongen, Thomas Kodger, Christopher Murray
Keywords(s): Electronic Materials, Nanotechnology, Optics & Photonics 
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents
Protein Function Scanning by Mass Spectrometry
High throughput, highly controlled mutagenesis method to study protein function of full-length proteins for protein engineering and testing, drug and antibody development, protein interaction and binding studies. Problem: Understanding a protein's functions requires studying each mutation separately through separation-of-function mutations. Traditional...
Published: 4/4/2025   |   Inventor(s): Roberto Bonasio, Julia Tasca
Keywords(s): Bioengineering, Platform Technology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
Bilayer Solid-State Nanopores for the Tracking, Filtering and Guiding of DNA
A bilayered solid-state nanopore material that senses and guides DNA and other biomolecules into homogeneous configurations. Problem: Current methods of DNA sensing and sequencing typically involve short read lengths, chemical labeling, labor-intensive sample preparation, and lack of portability. To minimize these issues during DNA sequencing, protein-based...
Published: 11/25/2024   |   Inventor(s): Marija Drndic, Yung-Chien Chou, Dimitrios Monos, Chih-Yuan Lin
Keywords(s): Nanotechnology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents
Contactless, Reversible Material Deposition From Liquid Droplets To Solid Surfaces
A microfluidic device allowing spatiotemporal manipulation of droplets that can be applied to high-resolution analytical techniques. Problem: Electrowetting methods such as electrowetting-on-dielectric (EWOD) have been developed to support high-resolution analytical techniques such as mass spectrometry and atomic force microscopy. EWOD allows processing...
Published: 1/17/2025   |   Inventor(s): Daeyeon Lee, Junhyong Kim, Paradorn Rummaneethorn
Keywords(s): Microfluidics
Category(s): Technology Classifications > Research Tools & Reagents
Photoactivated Selective Release (PHASR) of Droplets from Microwell Arrays
A photoresponsive polymer layer that can be integrated into microfluidic devices for selective release of unique droplets Problem: Droplet microfluidics are used for single molecule detection and analysis, such as isolation of protein biomarkers for monitoring of disease progression. Current techniques for recovering unique molecules or cells from droplet...
Published: 1/17/2025   |   Inventor(s): Daeyeon Lee, Junhyong Kim, Yongwon Choi, Syung-Hun Han
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Microfluidics, Nanotechnology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents
Fluorescent Probes for the Selective Detection of Alzheimer's and Parkinson's Diseases
Bimane-based fluorescent probes with turn-on fluorescence in the presence of α-synuclein, a known hallmark of Altzeimer’s and Parkinson’s diseases. Problem: Small fluorogenic probes with high sensitivity and selectivity are powerful tools for studying the accumulation of amyloid fibrils in cells or tissue samples from patients with...
Published: 6/27/2024   |   Inventor(s): E. James Petersson, Venkatesh Yarra
Keywords(s):  
Category(s): Technology Classifications > Research Tools & Reagents
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