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Mechanically Tunable Engineered Heart Tissue Platform
Next-generation engineered heart tissue platform that enables precise tuning of mechanical properties of microenvironment to study the structure, development, and function of cultured cells or human-derived cardiac tissues. Problem: Engineering heart tissue (EHT) platforms have the potential to study heart physiology, disease pathology, and therapeutic...
Published: 1/30/2026   |   Inventor(s): Kenneth Margulies, Benjamin Lee, Nesrine Bouhrira
Keywords(s): Bioengineering, Cardiovascular, Drug Target, Platform Technology
Category(s): Technology Classifications > Hardware & Components, Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
A Method for One-Step, Aqueous Phase Generation of Ultrasmall Inorganic Nanoparticles for Biomedical Applications.
A method to generate homogenous and stable inorganic nanoparticles (NPs) using a microfluidic device with two jet inlets. Problem: Inorganic nanoparticles have promise as contrast agents and therapeutics due to their high renal clearance and therefore low toxicity. However, they are limited by factors including complex synthesis routes with unfavorable...
Published: 1/21/2026   |   Inventor(s): David Cormode, Hyun (Michel) Koo, Nil Kanatha Pandey, Andrea Kian, Portia Maidment, Derick Rosario Berrios
Keywords(s): Microfluidics, Platform Technology, Radiology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents
An Improved In Vivo Gene-Editing System Using Plug-and-Play Lipid Nanoparticles (LNPs) to Support CRISPR, Small Interfering RNA (siRNA), and Adenine Base Gene Editing Platforms
Simple, plug-and-play biodegradable lipids that form highly potent lipid nanoparticles (LNPs) for CRISPR mRNA delivery, outperforming benchmark gene-editing systems. Problem: CRISPR therapies can permanently correct disease-causing genes, but today's CRISPR delivery systems are either too risky or not potent enough. Viral vectors raise red flags...
Published: 1/14/2026   |   Inventor(s): Michael Mitchell, Xuexiang Han, Kelsey Swingle, Alex Hamilton
Keywords(s): Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Nanotechnology, Platform Technology, Protein/Peptide (Non-Antibody), Small Molecule
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Research Tools & Reagents
Instant, Calibration-Free Blood-Flow Measurement With A Single Optical Snapshot
A single-frame, multi-exposure time optical method enabling accurate extraction of absolute speckle decorrelation time and optimized for recovery of absolute deep-tissue blood flow. Problem: Accurately recovering absolute speckle decorrelation time without the use of calibration or complex instrumentation is challenging. For the use case of monitoring...
Published: 1/8/2026   |   Inventor(s): Arjun Yodh, Wesley Baker, Joseph Majeski, Rodrigo Menezes Forti
Keywords(s): Bioengineering, Cardiovascular, Electronic Materials, Gastroenterology, Internet of Things, Nephrology and Urology, Neurology, Oncology, Ophthalmology, Optics & Photonics , Platform Technology, Surgery
Category(s): Technology Classifications > Computer Information Systems, Technology Classifications > Diagnostics, Technology Classifications > Digital Health, Technology Classifications > Hardware & Components, Technology Classifications > Imaging, Technology Classifications > Research Tools & Reagents, Technology Classifications > Medical Devices, Technology Classifications > Testing & Measurement
T Cells Targeting Misformed Proteins to Treat Neurodegenerative and Muscular Diseases
Antigen-specific immunotherapy with engineered cytotoxic T cells targeting misformed proteins to treat neurodegenerative and muscular diseases. Problem: Neurodegenerative and muscular diseases, such as amyotrophic lateral sclerosis (ALS), inclusion body myositis (IBM), and Alzheimer’s disease (AD), collectively affect over 5 million adults...
Published: 11/11/2025   |   Inventor(s): Ning Jenny Jiang, Shahab Chizari
Keywords(s): Bioengineering, Cell Therapy, Immunology, Immunotherapy, Inflammation, Neurodegenerative Diseases
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Human Artificial Chromosome Generation Technology
Technology allowing efficient formation, delivery, isolation, and enrichment of single-copy Human Artificial Chromosome (HAC) for use in research, plant production, gene and cell therapy and more. Problem: Existing gene-editing techniques have limitations due to their reliance on viruses for delivery, restricting their packaging capacities. A more potent...
Published: 9/19/2025   |   Inventor(s): Ben Black, Craig Gambogi, John Glass, David Brown, Gabriel Birchak
Keywords(s): Bioengineering, Gene Editing, Gene Therapy, Genetic Disorders, Platform Technology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Ultrasensitive, High-Throughput, Single-Scale Detection of Extracellular Vesicles
An optofluidic platform to detect extracellular vesicles (EVs) at the single-particle level by parallelizing droplet generation and analysis of EVs. Problem: Extracellular vesicles (EVs) are lipid bound nanomaterials carrying various molecular cargo that can be representative of their cells of origin. EVs play a critical role in intercellular communication...
Published: 9/10/2025   |   Inventor(s): David Issadore, Zijian Yang
Keywords(s): Bioengineering, Microfluidics, Optics & Photonics , Platform Technology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
LNP + Squeeze: Enhancing Chimeric Antigen Receptor T-Cell Generation via Mechanoporation and Lipid Nanoparticles
Synergistic combination of mechanoporation and lipid nanoparticle (LNP) based transfection for an efficient, non-viral method of gene transfer to generate CAR-T cell therapies. Problem: Chimeric antigen receptor (CAR)-T cell therapy has transformed cancer treatment by engineering patients' T cells to precisely target and eradicate cancer cells....
Published: 8/28/2025   |   Inventor(s): Jina Ko, Jianhua Lim
Keywords(s): Bioengineering, Cell Therapy, Gene Editing, Immunology, Immunoncology, Microfluidics, Nanotechnology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Chemical Processes and Synthesis
Comprehensive Quantification of Animal Behavior at Ultra-High Resolution
Advantages: Behavior is the ultimate readout of nervous system function. We have developed a method for monitoring movement as well as the principal effectors of behavior, muscles, at unprecedented scale and resolution. Our approach is poised for widespread adoption and will enable new breakthroughs in both clinical and basic research. Problem: Behavioral...
Published: 8/11/2025   |   Inventor(s): Timothy Machado, Jeffrey Gauthier, Michael Economo, Kate Hong
Keywords(s): Neurology, Optics & Photonics , Platform Technology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
Intranasal Dantrolene Nanoparticle Use For Treatment Of Alzheimer's Disease
Intranasal delivering of dantrolene nanoparticles could potentially be used to inhibit memory loss and reduce amyloid plaques in patients with Alzheimer's disease. Problem: Alzheimer’s disease (AD) is a devastating neurodegenerative disease. The deficit in the development of new drugs targeting the amyloid pathology over the past several...
Published: 8/1/2025   |   Inventor(s): Huafeng Wei, Qing Cheng Meng, Ge Liang, Maryellen Eckenhoff
Keywords(s): Aging, COVID-19, Nanotechnology, Neurodegenerative Diseases
Category(s): Technology Classifications > Animal Health, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Food Science and Nutrition, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
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