Search Results - e.+james+petersson

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Fluorescent Probes for the Selective Detection of Alzheimer's and Parkinson's Diseases
Bimane-based fluorescent probes with turn-on fluorescence in the presence of α-synuclein, a known hallmark of Altzeimer’s and Parkinson’s diseases. Problem: Small fluorogenic probes with high sensitivity and selectivity are powerful tools for studying the accumulation of amyloid fibrils in cells or tissue samples from patients with...
Published: 6/27/2024   |   Inventor(s): E. James Petersson, Venkatesh Yarra
Keywords(s):  
Category(s): Technology Classifications > Research Tools & Reagents
PET Radiotracers for Diagnosis and Patient Stratification of Neurodegenerative Disorders
Small molecules that bind to alpha-synuclein deposition and can be used for PET imagining in patients with synucleinopathies Problem: Imaging alpha-synuclein (αS) using noninvasive techniques such as positron emission tomography (PET) can help with the early diagnosis of synucleinopathies. Previous PET radiotracers suffer from low binding affinity...
Published: 6/6/2024   |   Inventor(s): Robert Mach, E. James Petersson
Keywords(s): Imaging Agents, Neurodegenerative Diseases, Radiology, Small Molecule
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Diagnostics, Technology Classifications > Imaging, Technology Classifications > Research Tools & Reagents
One step N-terminal tagging of endogenous proteins for therapeutic delivery, diagnostics, and in vivo imaging
N-Terminal protein modification using adenosine substrates and aminoacyl transferase Problem: The conjugation of synthetic molecules to the termini of proteins with minimal effects on protein folding and function is an active area of biochemical research. Previous N-terminal protein modification methods suffer from side reaction products, incomplete...
Published: 1/5/2024   |   Inventor(s): E. James Petersson, Alan Saghatelian
Keywords(s):  
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Non-perturbative, site-specific labeling of α-synuclein for studying amyloid disease and screening therapeutics
Fluorescently labeled α-synuclein to examine destabilization of synuclein fibrils by small molecules and therapeutics for neurodegenerative diseases Problem: Misfolding of the neuronal protein α-synuclein triggers oligomerization and the formation of amyloid fibrils that are the pathological hallmarks of Parkinson’s disease. The...
Published: 1/5/2024   |   Inventor(s): E. James Petersson
Keywords(s):  
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Imaging
Thioamide-modified peptides for stabilized therapeutics and drug development
Natural bioactive peptides and hormones with thioamide substitutions at cleavage sites for improved pharmacokinetics Problem: Natural bioactive peptides are attractive lead pharmaceutical compounds, but peptides are subjected to rapid proteolysis in vivo. The majority of the time spent in peptide biologic drug development seeks to reduce this protein...
Published: 1/5/2024   |   Inventor(s): E. James Petersson
Keywords(s):  
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics, Technology Classifications > Materials
Reconstructing 3D Shapes from 2D Images Using 2D Active Appearance Models and 3D Point Distribution Models
PAGE TITLE Overview PAGE SUMMARY Drexel University’s biomedical engineers have developed a method for reconstructing accurate 3-dimentional surface representations of the ribs from anterior-posterior 2-dimentional radiographs using combined 2D active appearance models and 3D point distribution models. This method was implemented in the MATLAB...
Published: 8/27/2024   |   Inventor(s): Sriram (sri) Balasubramanian, James Peters
Keywords(s):  
Category(s): Computing, Software, Analytics & Information Technology, Digital Health & Healthcare IT, Digital Health & Healthcare IT > Dig. Health: Imaging, Computing, Software, Analytics & Information Technology > Computing: 3D Search and Classification, Computing, Software, Analytics & Information Technology > Computing: Algorithms, Computing, Software, Analytics & Information Technology > Computing: Imaging Analysis