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Search Results - stem+cells+and+regenerative+medicine
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Cell and Collagen Compositions for Engineered Cardiac Tissues for Regeneration
Cell and Collagen Compositions for Engineered Cardiac Tissues for Regeneration Overview During a heart attack it is estimated that 1 billion cardiomyocytes (i.e. heart muscle cells) are killed. Unlike other organs in the body, the heart has a limited capacity to regenerate. This means that the cardiomyocytes lost during a heart attack are replaced...
Published: 11/3/2025
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Updated: 11/25/2024
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Inventor(s):
Kareen Coulombe
,
Kiera Dwyer
,
Rajeev Kant
Keywords(s):
Category(s):
Stem Cells and Regenerative Medicine
Quantifying Cell-Derived Changes in Collagen Synthesis, Alignment, and Mechanics in a 3D Connective Tissue Model
Quantifying Cell-Derived Changes in Collagen Synthesis, Alignment, and Mechanics in a 3D Connective Tissue Model Overview The extracellular matrix (ECM) of the body is the network of proteins and other molecules that surrounds cells and tissues. The ECM is directly involved in a variety of essential cellular processes including structural support,...
Published: 10/31/2025
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Updated: 11/25/2024
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Inventor(s):
Jeffrey Morgan
,
Benjamin Wilks
Keywords(s):
Category(s):
Stem Cells and Regenerative Medicine
,
Research Tools
,
Drug Discovery Platform
Mid-scale vessels in engineered tissue for regeneration
Overview Vascularization is a primary concern when developing implantable cardiac tissues, as it is critical for superior engraftment and integration. We have developed a method for engineering a vascular supply for engineered human myocardium to ensure tissue survival and engraftment upon implantation and improve therapeutic efficacy. Market Opportunity Myocardial...
Published: 5/22/2026
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Updated: 8/22/2024
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Inventor(s):
Kareen Coulombe
,
Rajeev Kant
,
Kiera Dwyer
Keywords(s):
Category(s):
Stem Cells and Regenerative Medicine
Novel proangiogenic cocktails of growth factors and cytokines to revascularize ischemic tissue
Overview Revascularization of ischemic tissue can be achieved using growth factors to recapitulate native developmental and wound healing cascades, and stimulate angiogenesis and arteriogenesis. These pro-vasculogenic growth factor cocktails can also increase the efficacy and translatability of regenerative therapeutics for clinical uses. We have developed...
Published: 11/24/2025
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Updated: 6/4/2023
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Inventor(s):
Kareen Coulombe
,
Alicia Minor
Keywords(s):
Category(s):
Stem Cells and Regenerative Medicine
Method for Making Small Diameter Living Tubes
Overview We have developed a funnel-guide device for the noncontact manipulation and positioning of multicellular microtissues, to build macrotissues layer by layer. One specific application is the fabrication of biological tubes. Market Opportunity A long-standing problem in 3D tissue engineering is how to fabricate large tissue constructs with...
Published: 10/31/2025
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Updated: 12/21/2022
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Inventor(s):
Jeffrey Morgan
,
Kali Manning
,
Blanche Ip
Keywords(s):
Category(s):
Stem Cells and Regenerative Medicine
Robust, Stable, and “Smart” Microstructure Drug Delivery for Controlled Release (Case 2035)
Robust, Stable, and “Smart” Microstructure Drug Delivery for Controlled Release Overview Effective “smart” fiber drug delivery systems must be multi-functional and provide both physical and pharmaceutical support. Our invention prepares and uses a multi-layer polymeric microstructure “smart” delivery system for...
Published: 4/22/2026
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Updated: 7/14/2020
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Inventor(s):
Edith Mathiowitz
,
Richard Hopkins
,
Danya Lavin (formerly Decoteau)
Keywords(s):
Category(s):
Drug Delivery
,
Stem Cells and Regenerative Medicine
,
Therapeutics
,
Devices
,
Nanotechnology
,
Research Tools
Improved Method of Manufacturing Nanowire Nanoarray Memories (Case 1709)
Principal Investigator: John Savage, PhD, Professor Department of Computer ScienceBrown UniversityProvidence, RIBrief Description:Methods have been developed for growing nanowires (NWs) and carbon nanotubes (NTs) with diameters of a few nanometers and for assembling NWs into nanoarrays, crossbars containing two orthogonal sets of parallel wires on...
Published: 3/5/2025
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Updated: 4/28/2020
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Inventor(s):
John Savage
,
Eric Rachlin
,
Andre Dehon
,
Charles Lieber
Keywords(s):
Category(s):
Devices
,
Diagnostics
,
Engineering and Sensors
,
Environmental
,
Metabolic diseases
,
Nanotechnology
,
Neuroscience
,
Oncology
,
Research Tools
,
Software
,
Stem Cells and Regenerative Medicine
Biological Pick, Place, and Perfuse "BioP3" - Device to Engineer Thick Living Tissues with High Cell Density (Case 2220) (EA)
Engineering Thick Living Tissues with High Cell Density Overview The ability to build organs in vitro will have a far-reaching impact on the field of tissue engineering, as well as other areas of research that use animals. Cells cultured in 3D mimic native tissues and organs much more effectively than do those cultured in 2D. While significant advances...
Published: 4/22/2026
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Updated: 4/7/2020
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Inventor(s):
Jeffrey Morgan
,
Anubhav Tripathi
,
William Patterson Iii
,
John Murphy
,
Andrew Blakely
Keywords(s):
Category(s):
Devices
,
Nanotechnology
,
Research Tools
,
Stem Cells and Regenerative Medicine
Advanced, Wireless, Implantable Neural Recording and Stimulation Microsystem (Case 2032)
Principal Investigator:Arto Nurmikko, PhD, ProfessorSchool of EngineeringBrown UniversityProvidence, RIBrief Description:With the advent of advanced materials, MEMs, microfluidics, nanotechnology and interdisciplinary research programs between engineering fields and the biomedical sciences, miniaturized, next generation devices are now being developed...
Published: 3/5/2025
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Updated: 6/20/2012
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Inventor(s):
Arto Nurmikko
,
Ming Yin
,
William Patterson Iii
,
Juan Aceros
,
David Borton
,
Christopher Bull
,
Farah Laiwalla
Keywords(s):
Category(s):
Devices
,
Diagnostics
,
Drug Delivery
,
Engineering and Sensors
,
Metabolic diseases
,
Nanotechnology
,
Neuroscience
,
Oncology
,
Research Tools
,
Stem Cells and Regenerative Medicine
Interactive, Multilayer, Multivalued Volume-Rendering for Superior 3D Images from MRI or Other Data (Case 1492)
Principal Investigator:David Laidlaw, PhD, ProfessorDepartment of Computer ScienceBrown UniversityProvidence, RIBrief Description:Magnetic resonance imaging (MRI) is a well-established and powerful technique for elucidating structure and is used, for example, in medical applications to discriminate between normal and pathological tissue. The MRI image...
Published: 10/15/2025
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Updated: 6/11/2012
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Inventor(s):
David Laidlaw
,
Andreas Wenger
Keywords(s):
Category(s):
Devices
,
Diagnostics
,
Engineering and Sensors
,
Instruments
,
Metabolic diseases
,
Neuroscience
,
Oncology
,
Research Tools
,
Software
,
Stem Cells and Regenerative Medicine
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