Search Results - drug+discovery+platform

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Proprietary targeting of Oligonucleotide to vulnerable splicing events to efficiently silence genes
Overview The principle of antisense technology is the sequence-specific binding of an antisense oligonucleotide (ASO) to target mRNA and prevent gene translation. We have found the individual events that are most vulnerable to disruption in cancer cells and developed a method to target these events. We can further restrict the points of vulnerability...
Published: 8/22/2024   |   Inventor(s): William Fairbrother, Jeremiah Buerer, David Glidden
Keywords(s):  
Category(s): Drug Discovery Platform, Therapy Targets
Development and Use of a High-Throughput Screen to Identify Novel Modulators of the Corticotropin Releasing Factor Binding Protein
­Development of a HT Screen to Identify Novel Modulators of the CRFBP Overview A connection between the corticotropin signaling pathway and alcohol use disorder (AUD) has been shown previously. We developed a high throughput screen to identify small molecule modulators of this pathway as potential therapeutics for AUD. Market Opportunity Currently...
Published: 9/14/2022   |   Inventor(s): Carolina Haass-Koffler
Keywords(s):  
Category(s): Drug Discovery Platform, Central Nervous System(CNS)