Search Results - kareen+coulombe

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Cell and Collagen Compositions for Engineered Cardiac Tissues for Regeneration
Cell and Collagen Compositions for Engineered Cardiac Tissues for Regeneration Overview During a heart attack it is estimated that 1 billion cardiomyocytes (i.e. heart muscle cells) are killed. Unlike other organs in the body, the heart has a limited capacity to regenerate. This means that the cardiomyocytes lost during a heart attack are replaced...
Published: 11/3/2025   |   Updated: 11/25/2024   |   Inventor(s): Kareen Coulombe, Kiera Dwyer, Rajeev Kant
Keywords(s):  
Category(s): Stem Cells and Regenerative Medicine
Mid-scale vessels in engineered tissue for regeneration
Overview Vascularization is a primary concern when developing implantable cardiac tissues, as it is critical for superior engraftment and integration. We have developed a method for engineering a vascular supply for engineered human myocardium to ensure tissue survival and engraftment upon implantation and improve therapeutic efficacy. Market Opportunity Myocardial...
Published: 5/22/2026   |   Updated: 8/22/2024   |   Inventor(s): Kareen Coulombe, Rajeev Kant, Kiera Dwyer
Keywords(s):  
Category(s): Stem Cells and Regenerative Medicine
Novel proangiogenic cocktails of growth factors and cytokines to revascularize ischemic tissue
Overview Revascularization of ischemic tissue can be achieved using growth factors to recapitulate native developmental and wound healing cascades, and stimulate angiogenesis and arteriogenesis. These pro-vasculogenic growth factor cocktails can also increase the efficacy and translatability of regenerative therapeutics for clinical uses. We have developed...
Published: 11/24/2025   |   Updated: 6/4/2023   |   Inventor(s): Kareen Coulombe, Alicia Minor
Keywords(s):  
Category(s): Stem Cells and Regenerative Medicine