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Search Results - metabolic+diseases
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Metabolite Treatments for Metabolic Dysfunction and Neurological Disease Caused by Mutations in Mitochondrial Enzyme GPT2
Overview The mitochondrial enzyme glutamate pyruvate transaminase 2 (GPT2) is necessary for metabolic mechanisms central to neuronal survival and axonal growth. Having demonstrated that loss-of-function mutations in GPT2 cause neuronal vulnerabilities involved in a variety of brain diseases and areas of brain function, we have developed a metabolite...
Published: 10/12/2022
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Inventor(s):
Eric Morrow
Keywords(s):
Category(s):
Metabolic diseases
,
Therapy Targets
METHODS AND COMPOSITIONS FOR TREATING OBESITY BY OPSIN 3 REGULATION OF HYPOTHALAMIC MELANOCORTIN RECEPTORS
Preventing and Treating Obesity through Opsin 3 Regulation of Hypothalamic Melanocortin Receptors Overview Obesity is a worldwide health problem. The complex disease disrupts many body systems and reduces life expectancy. Our technology offers a safe, effective way to prevent and treat obesity and obesity-related disorders through opsin 3 regulation...
Published: 6/6/2023
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Inventor(s):
Elena Oancea
Keywords(s):
Category(s):
Therapeutics
,
Metabolic diseases
Improved Method of Manufacturing Nanowire Nanoarray Memories (Case 1709)
Principal Investigator: John Savage, PhD, Professor Department of Computer ScienceBrown UniversityProvidence, RIBrief Description:Methods have been developed for growing nanowires (NWs) and carbon nanotubes (NTs) with diameters of a few nanometers and for assembling NWs into nanoarrays, crossbars containing two orthogonal sets of parallel wires on...
Published: 4/28/2022
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Inventor(s):
John Savage
,
Eric Rachlin
,
Andre Dehon
,
Charles Lieber
Keywords(s):
Category(s):
Devices
,
Diagnostics
,
Engineering and Sensors
,
Environmental
,
Metabolic diseases
,
Nanotechnology
,
Neuroscience
,
Oncology
,
Research Tools
,
Software
,
Stem Cells and Regenerative Medicine
New and Improved Antibacterial Compounds (Case 2062)
Principal Investigator:Jason Sello, PhD, Assistant ProfessorDepartment of Chemistry Brown UniversityProvidence, RIBrief Description: Infectious diseases are the second leading cause of death – globally. Antibiotic drug resistance is a major clinical and societal problem, with many...
Published: 4/21/2023
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Inventor(s):
Jason Sello
Keywords(s):
Category(s):
Drug Delivery
,
Metabolic diseases
,
Oncology
Screening Method for Inhibitors of Multidrug-Resistance Transporters (Case 2079)
Novel Screening Method for Inhibitors of Multidrug-Resistant Transporters Overview Drug transport is of fundamental importance to the efficacy and toxicity of all drugs. From the route of administration to the site of action, a drug encounters numerous biological barriers, including efflux pumps that pump drugs out of cells. Our novel method uses...
Published: 10/24/2023
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Inventor(s):
Jeffrey Morgan
,
Anubhav Tripathi
,
Toni-Marie Achilli (formerly Ferrucc
,
Stephanie Mccalla
Keywords(s):
Category(s):
Drug Delivery
,
Oncology
,
Research Tools
,
Diagnostics
,
Metabolic diseases
Advanced, Wireless, Implantable Neural Recording and Stimulation Microsystem (Case 2032)
Principal Investigator:Arto Nurmikko, PhD, ProfessorSchool of EngineeringBrown UniversityProvidence, RIBrief Description:With the advent of advanced materials, MEMs, microfluidics, nanotechnology and interdisciplinary research programs between engineering fields and the biomedical sciences, miniaturized, next generation devices are now being developed...
Published: 7/12/2022
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Inventor(s):
Arto Nurmikko
,
Ming Yin
,
William Patterson Iii
,
Juan Aceros
,
David Borton
,
Christopher Bull
,
Farah Laiwalla
Keywords(s):
Category(s):
Devices
,
Diagnostics
,
Drug Delivery
,
Engineering and Sensors
,
Metabolic diseases
,
Nanotechnology
,
Neuroscience
,
Oncology
,
Research Tools
,
Stem Cells and Regenerative Medicine
Interactive, Multilayer, Multivalued Volume-Rendering for Superior 3D Images from MRI or Other Data (Case 1492)
Principal Investigator:David Laidlaw, PhD, ProfessorDepartment of Computer ScienceBrown UniversityProvidence, RIBrief Description:Magnetic resonance imaging (MRI) is a well-established and powerful technique for elucidating structure and is used, for example, in medical applications to discriminate between normal and pathological tissue. The MRI image...
Published: 2/14/2023
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Inventor(s):
David Laidlaw
,
Andreas Wenger
Keywords(s):
Category(s):
Devices
,
Diagnostics
,
Engineering and Sensors
,
Instruments
,
Metabolic diseases
,
Neuroscience
,
Oncology
,
Research Tools
,
Software
,
Stem Cells and Regenerative Medicine
Improved, Scalable, Optical Particle/Molecule Detector System by Solid State Energy Sources (Case 1494)
Principal Investigator:Arto Nurmikko, PhD, ProfessorSchool of EngineeringBrown UniversityProvidence, RIBrief Description:With environmental safety and defense/bioterrorism concerns, and the continuing drive for important medical breakthroughs, quick and accurate particle diagnostic capabilities have become increasingly important to identify and quantify...
Published: 8/13/2024
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Inventor(s):
Arto Nurmikko
,
Richard Chang
Keywords(s):
Category(s):
Devices
,
Diagnostics
,
Energy
,
Engineering and Sensors
,
Environmental
,
Instruments
,
Metabolic diseases
,
Nanotechnology
,
Neuroscience
,
Oncology
,
Research Tools
,
Stem Cells and Regenerative Medicine
Advanced, Sensitive, Broad Tractography Metrics to Characterize Cerebral White Matter (Case 1732)
Principal Investigator: David Laidlaw, PhD, Professor Department of Computer ScienceBrown UniversityProvidence, RIBrief Description:Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique that measures the directionally dependent rate of water self-diffusion in each image voxel or volumetric picture element - a 3-dimensional...
Published: 2/14/2023
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Inventor(s):
David Laidlaw
,
Song Zhang
,
Stephanie Lee
Keywords(s):
Category(s):
Devices
,
Diagnostics
,
Environmental
,
Instruments
,
Metabolic diseases
,
Neuroscience
,
Oncology
,
Research Tools
,
Software
,
Stem Cells and Regenerative Medicine
Advanced, Flexible and Versatile, 3D Electromagnetic Tracking and Positioning System (Case 1780)
Principal Investigator:Harvey Silverman, PhD, ProfessorSchool of EngineeringBrown UniversityProvidence, RIBrief Description:A typical system for determining the position and orientation of a remote object includes, most simply, a receiver with three receiver coils and a transmitter with three transmitter coils in various orientations to one another...
Published: 6/10/2022
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Inventor(s):
Harvey Silverman
,
William Patterson Iii
Keywords(s):
Category(s):
Devices
,
Diagnostics
,
Drug Delivery
,
Energy
,
Engineering and Sensors
,
Environmental
,
Instruments
,
Metabolic diseases
,
Nanotechnology
,
Neuroscience
,
Oncology
,
Research Tools
,
Software
,
Stem Cells and Regenerative Medicine
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