Noncationic Nucleic Acid-Polymer Complexes for Nucleic Acid Delivery

PRODUCT OPPORTUNITIES

• Noncationic nucleic acid-polymer complexes for nucleic acid delivery
• Nucleic acid-polymer complexation kits for nucleic acid encapsulation and intracellular delivery
• Novel polymers for nucleic acid delivery with substantially reduced cytotoxicity

PRODUCT OPPORTUNITIES

COMPETITIVE ADVANTAGES

• An efficient nucleic acid delivery system with substantially reduced cytoxicity
• Robust nucleic acid complexation and encapsulation
• Stimuli-responsive release of nucleic acids
• Applicable to the delivery and intracellular release of a variety of nucleic acids, such as DNA, micro-RNA, siRNA and mRNA

TECHNOLOGY DESCRIPTION

This invention provides a new strategy for nucleic acid delivery by using novel cross-linkable and surface-charge modifiable synthetic polymers. The use of the novel polymer system allows for robust nuclecid-polymer complexation, easy removal of cationic moieties of the polymer and self-crosslinking of the polymer in a single step, and stimuli-responsive release of the nucleic acid molecules in the cell.

ABOUT THE INVENTOR

Dr. Thayumanavan is a Professor in the Department of Chemistry. He is a highly accomplished expert in organic and polymer chemistry and a prolific inventor. His research focuses on the design, synthesis and characterization of organic macromolecules of interest in supramolecular chemistry, materials science and biological applications. Dr. Thayumanavan has broad and well-established expertise in developing custom-designed molecules for specific end-use applications such as pharmaceutical delivery, smart sensors, and fuel cells.

AVAILABILITY:

Available for Licensing and/or Sponsored Research

DOCKET:

UMA 16-043

PATENT STATUS:

Patent Pending

NON-CONFIDENTIAL INVENTION DISCLOSURE

LEAD INVENTOR:

S. Thai Thayumanavan, Ph.D.

CONTACT:

This invention provides a new strategy for nucleic acid delivery by using novel cross-linkable and surface-charge modifiable synthetic polymers. The use of the novel polymer system allows for robust nuclecid-polymer complexation, easy removal of cationic moieties of the polymer and self-crosslinking of the polymer in a single step, and stimuli-responsive release of the nucleic acid molecules in the cell.