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Therapeutic Inhibition of Molecular Drivers of Microglial Reactivity in Neurodegenerative Disease

It is estimated that over 55 million people have Alzheimer’s disease (AD) or other dementias, and despite their rapidly increasing burden, thus far there are no disease modifying therapeutics available. Novel therapeutic strategies are urgently needed to address the prevention and treatment of AD. Mounting evidence from large scale genetic studies...

Published: 2/14/2024 | Inventor(s): Benjamin Readhead, Qi Wang, Diego Mastroeni, Eric Reiman

Keywords(s):

Category(s): Life Science (All LS Techs), Neurodegenerative Disease Technologies

Recovering Critical Elements from Acid Mine Drainage

THE CHALLENGE The demand for certain elements, such as Manganese (Mn), Cobalt (Co), and Nickel (Ni), has surged in recent years due to the rapid growth of battery production for electric vehicles and utility-scale energy storage. The United States government has deemed Co, Ni, and Mn critical elements, primarily because of the country’s high...

Published: 6/26/2024 | Inventor(s): Wencai Zhang, Qi Li, Rick Honaker

Keywords(s):

Category(s): Technology Classifications > Energy, Technology Classifications > Mining and Recycling, Technology Classifications, Technology Classifications > Chemicals/Materials

Stable Biological Membrane Mimetic For Enhanced Protein Recruitment

Synthetic biological alternative to natural lipids for conjugation with nitrilotriacetic acid (NTA) for enhanced His-tagged protein interaction and long-term stability. Problem: Biomimetic lipid vesicles, such as liposomes, have multiple biotechnology and drug delivery applications as their lipid bilayer innately interacts with natural cell membranes....

Published: 10/16/2023 | Inventor(s): Virgil Percec, Qi Xiao, Matthew Good

Keywords(s): Bioengineering, Platform Technology

Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents

Human Monoclonal Antibodies Cross-reacting to Insulin-like Growth Factors IGF-I and IGF-II as Potential Anti-tumor Agents

Abstract: The National Cancer Institute's Cancer and Inflammation Program is seeking statements of capability or interest from parties interested in licensing this technology. The type 1 insulin-like growth factor (IGF) receptor (IGF1R) is over-expressed by many tumors and mediates proliferation, motility, and protection from apoptosis. Agents that...

Published: 5/22/2024 | Inventor(s): Dimiter Dimitrov, Qi Zhao, Zhongyu Zhu

Keywords(s): Dimitrov, IGF-I, IGF-II, insulin-like growth factor, Monoclonal Antibody

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology

CAPACITIVE ARTIFICIAL NEURAL NETWORKS

APPLICATIONS Applications include pattern recognition, image processing, natural language understanding, robotics, and other fields where machine learning and artificial intelligence techniques are applied. APPLICATIONSTECHNOLOGY DESCRIPTION The invention introduces a technology that utilizes capacitative components to implement artificial...

Published: 6/26/2023 | Inventor(s): Jianhua (joshua) Yang, Qiangfei Xia, Mark McLean, Zhongrui Wang, Qing Wu

Keywords(s):

Category(s): Computers, Electronics, Engineering, Communications & internet

ARTIFICIAL NEURONS USING DIFFUSIVE MEMRISTOR

APPLICATIONS Applications include pattern recognition, machine learning, artificial intelligence, robotics, and other areas where brain-inspired computing paradigms are beneficial. APPLICATIONS ADVANTAGES Advantages include their low power consumption, high density integration, non-volatility, and compatibility with existing semiconductor...

Published: 6/26/2023 | Inventor(s): Jianhua (joshua) Yang, Qiangfei Xia, Mark McLean, Qing Wu

Keywords(s):

Category(s): Devices, Computers, Communications & internet, Devices & sensors, Electronics, Engineering, Nanotechnology

Method for In Vivo Detection of Cell-Surface Disease Markers

A pair of compatible reagents, one antibody-based biomarker target and one small molecule PET tracer, combine to provide a high affinity, disease specific detection system. Background: The medical diagnostics industry has an urgent demand for efficient non-invasive biomarkers to diagnose and stage disease progression for cancer and Alzheimer's...

Published: 6/26/2024 | Inventor(s): Qing Lin, Ming Fang, Gangam Kumar

Keywords(s): Featured, Technologies

Category(s): Campus > University at Buffalo, Technology Classifications, Technology Classifications > Healthcare, Technology Classifications > Medical Imaging

Treatment for the Prevention of Permanent Vision Loss in Glaucoma Patients

Problem: Glaucoma is the number one cause of irreversible blindness worldwide. High pressure in the eye can lead to optic nerve damage, which can progress to permanent vision loss. For this reason, reduction of intraocular pressure is the main therapeutic mechanism available. Unfortunately, glaucoma can continue to progress even in patients with normalized...

Published: 1/12/2024 | Inventor(s): Qi Cui, Joshua Dunaief, Jacob Sterling

Keywords(s): Ophthalmology, Small Molecule

Category(s): Technology Classifications > Therapeutics

Diffusive Memristor as a Synapse

Neuromorphic computing, systems designed to mimic the biological nervous system, require far less power than current computer processors. The increased efficiency makes feasible artificial intelligence applications for smaller, hand-held devices (e.g. smartphones, tablets). To this end, UMass inventors have designed hardware components that mimic neuronal...

Published: 6/26/2023 | Inventor(s): Jianhua (joshua) Yang, Qiangfei Xia, Mark McLean, Qing Wu, Mark Barnell

Keywords(s):

Category(s): Devices, Engineering, Physical Science, Communications & internet, Computers

COMBINATION THERAPIES FOR COVID-19 (SARS-COV-2)

The coronavirus disease 2019 (COVID-19) is caused by a novel RNA enveloped coronavirus, SARS-CoV-2 when the virus enters human airway cells via an ACE2-mediated entry process. This entry pathway is facilitated by the cell surface heparan sulfate proteoglycan (HSPG), which enhances viral attachment to the cell surface. Researchers at NIDDK and NCATS...

Published: 7/25/2024 | Inventor(s): Qi Zhang, Wei Zheng, Catherine Chen, Yihong Ye

Keywords(s): COVID-19, DB4BXX, ENTRY, HEPARAN, option, Sulfate-dependent, Targeting, therapeutic, viral

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Therapeutics

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