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Search Results - jiayi+he
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Biocompatible photoenzymatic system for selective C–H fluorination
Background C–H fluorination plays a central role in pharmaceutical and agrochemical synthesis, as the introduction of fluorine often enhances a molecule's metabolic stability, potency, and bioavailability. Over 20% of approved drugs contain fluorinated functional groups, underscoring the demand for efficient and selective fluorination methods....
Published: 7/31/2025
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Inventor(s):
Yi Lu
,
Yu Zhou
Keywords(s):
Category(s):
Life sciences > Metabolic engineering
Multi-List Strategy for Spectrum Interference Management
THE CHALLENGE Spectrum managers operating in shared-spectrum environments (e.g., the CBRS band) face a critical challenge: protecting high-priority incumbents such as Navy radar while maintaining reliable service for commercial users. Static move lists—the prevailing industry approach—repeatedly shut down the same base stations during...
Published: 7/16/2025
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Inventor(s):
Naru Jai
,
Yubo Wu
,
Yi Shi
,
Yiwei Thomas Hou
Keywords(s):
Category(s):
Technology Classifications > Communication
DNA-based sensors for live-cell mapping of metabolite- and metal ion-protein interactions
Background Understanding how metabolites and metal ions interact with proteins inside living cells is essential for decoding cellular signaling, metabolic regulation, and disease mechanisms. These small molecules function as cofactors, second messengers, and allosteric regulators, orchestrating critical pathways that govern cell behavior. However,...
Published: 6/16/2025
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Inventor(s):
Yi Lu
,
Mandira Banik
Keywords(s):
Category(s):
Life sciences > Research tools > Tool/assay/screening platform
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Life sciences > Immunology > Genomics/genetics
Artificial nitrogenase enzymes for ambient-condition, decentralized ammonia production
Background Ammonia synthesis is foundational to global agriculture and chemical manufacturing, providing the primary source of fixed nitrogen for fertilizers, polymers, and pharmaceuticals. Traditional ammonia production through the Haber-Bosch process, however, operates under extreme conditions—temperatures exceeding 400°C and pressures...
Published: 7/2/2025
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Inventor(s):
Yi Lu
,
Hirbod Heidari
,
Markus Ribbe
,
Yilin Hu
,
Chi Chung Lee
,
Evan Mirts
Keywords(s):
Category(s):
Life sciences > Therapeutics > Synthetic biology
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Life sciences > Metabolic engineering
Ease-of-manufacture Highly Transparent Thin Polyvinyl Alcohol Aerogel
Energy-efficient and cost-effective method for manufacturing transparent and robust PVA aerogels for green energy applications Background: Aerogels, particularly silica-based variants, have been widely used for their exceptional thermal insulation and transparency. However, their fragility has posed significant challenges for broader applications,...
Published: 6/13/2025
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Inventor(s):
Yi Zheng
,
Xiaoli Li
Keywords(s):
Category(s):
Technology Classifications > 2. Physical Science > Advanced materials/Nanomaterials
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Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering
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Technology Classifications > 2. Physical Science > Environmental/Clean tech
Biodegradable Polymers for Gene Delivery
Invention Summary: In gene therapy, a key challenge is delivering therapeutic genes to target cells, which requires gene delivery vectors. While viral vectors are effective, they pose risks such as immune responses and toxicity. Non-viral vectors, particularly cationic polymers, are preferred for their safety, cost-effectiveness, and high...
Published: 6/5/2025
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Inventor(s):
Adam Gormley
,
David Radford
,
Prajakatta Mulay
,
Jia Niu
,
Brayan Rondon
Keywords(s):
Category(s):
Technology Classifications > Agriculture
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Technology Classifications
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Technology Classifications > Physical Sciences & Engineering
RNA-aptamer-mediated Bacteriophage Purification
A more productive, less expensive method for purifying nanoscale biological entities such as bacteriophages, viruses, virus-like particles (VLPs), and ribosomes. Background: Working with nanometer-sized biological entities, such as viruses, virus-derivatives, and super-molecular assemblies, typically requires a purification step. Currently, this...
Published: 5/13/2025
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Inventor(s):
Ing-Nang Wang
,
Hua Shi
,
Jia Sheng
,
Alan Chen
Keywords(s):
bacteriophage purification
,
phage purification
,
phage therapy
,
RNA aptamer
,
Technologies
Category(s):
Campus > University at Albany
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Technology Classifications > Biological Materials
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Technology Classifications > Biomedical Science and Engineering
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Technology Classifications > Healthcare
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Technology Classifications > Research Tools and Reagents
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Technology Classifications > Therapeutics and Vaccines
Drug Discovery Based on Surface-Enhanced Raman Spectroscopy (SERS)
Enables drug discovery without introducing modifications to the molecules, while lowering costs by requiring only small amounts of the tested molecules. Background: Surface-enhanced Raman spectroscopy (SERS) is a novel, label-free, sensitive, specific, fast, and relatively inexpensive tool for drug discovery. It offers the potential to detect and...
Published: 5/13/2025
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Inventor(s):
Igor Lednev
,
Lamyaa Almehmadi
,
Jia Sheng
Keywords(s):
Raman spectroscopy
,
RNA
,
RNA chemistry
,
TAF
,
Technologies
Category(s):
Campus > University at Albany
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Technology Classifications > Antibodies
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Technology Classifications > Biomedical Science and Engineering
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Technology Classifications > Drug Delivery
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Technology Classifications > Healthcare
,
Technology Classifications > Therapeutics and Vaccines
Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay
Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...
Published: 5/30/2025
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Inventor(s):
Yong Zeng
,
He Yan
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Diagnostics
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Technology Classifications > Veterinary > Diagnostics
Precision cellular imaging for advanced biological analysis
A novel DNA-based imaging technique enabling visualization of 3D cellular components with super-resolution. Background Super-resolution microscopy has revolutionized biological research by providing finer details beyond the diffraction limit of conventional microscopy. A particular challenge in this field is the visualization of small and dynamic...
Published: 3/4/2025
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Inventor(s):
Yi Lu
,
Quanbing Mou
Keywords(s):
Category(s):
Life sciences > Imaging
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Life sciences > Research tools > Tool/assay/screening platform
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