Search Results - jiayi+he

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RNA-aptamer-mediated Bacteriophage Purification
A more productive, less expensive method for purifying nanoscale biological entities such as bacteriophages, viruses, virus-like particles (VLPs), and ribosomes. Background: Working with nanometer-sized biological entities, such as viruses, virus-derivatives, and super-molecular assemblies, typically requires a purification step. Currently, this...
Published: 4/1/2025   |   Inventor(s): Ing-Nang Wang, Hua Shi, Jia Sheng, Alan Chen
Keywords(s): bacteriophage purification, phage purification, phage therapy, RNA aptamer, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Research Tools and Reagents, Technology Classifications > Therapeutics and Vaccines
Drug Discovery Based on Surface-Enhanced Raman Spectroscopy (SERS)
Enables drug discovery without introducing modifications to the molecules, while lowering costs by requiring only small amounts of the tested molecules. Background: Surface-enhanced Raman spectroscopy (SERS) is a novel, label-free, sensitive, specific, fast, and relatively inexpensive tool for drug discovery. It offers the potential to detect and...
Published: 4/1/2025   |   Inventor(s): Igor Lednev, Lamyaa Almehmadi, Jia Sheng
Keywords(s): Raman spectroscopy, RNA, RNA chemistry, TAF, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Antibodies, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay
Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...
Published: 3/4/2025   |   Inventor(s): Yong Zeng, He Yan
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Veterinary > Diagnostics
Precision cellular imaging for advanced biological analysis
A novel DNA-based imaging technique enabling visualization of 3D cellular components with super-resolution. Background Super-resolution microscopy has revolutionized biological research by providing finer details beyond the diffraction limit of conventional microscopy. A particular challenge in this field is the visualization of small and dynamic...
Published: 3/4/2025   |   Inventor(s): Yi Lu, Quanbing Mou
Keywords(s):  
Category(s): Life sciences > Imaging, Life sciences > Research tools > Tool/assay/screening platform
Nanoparticles for Precise & Targeted Treatment of Neurological Conditions
Problem: Acute ischemic stroke (AIS) is the second leading cause of death worldwide, affecting around 600,000 Americans annually. However, pharmacological treatment of AIS is difficult due to ineffective and nonspecific targeting to blood brain barrier epitopes via intravenous administration. Over 100 drugs have been tried and failed in clinical trials...
Published: 2/20/2025   |   Inventor(s): Oscar Marcos Contreras, Jacob Brenner, Vladimir Muzykantov, Jia Nong, Patrick Glassman, Drew Weissman, Sahiley Reyes-Esteves
Keywords(s): Drug Delivery, Inflammation, Nanotechnology, Neurology
Category(s): Technology Classifications > Therapeutics
DNAzyme sensor for selective manganese ion detection in biological systems
A selective DNAzyme-based fluorescent sensor detects manganese ions in cells by lighting up when Mn²⁺ binds, allowing precise monitoring of manganese levels for biological research and potential therapies. Background Manganese (Mn²⁺) is an essential trace element integral to numerous biological processes, acting as a vital cofactor for enzymes...
Published: 1/31/2025   |   Inventor(s): Yi Lu, Zhenglin Yang, Huanhuan Fan
Keywords(s):  
Category(s): Life sciences > Biomaterials
DNAzyme fluorescent sensors for bioselective imaging of Fe²⁺ and Fe³⁺ ions
Developed DNAzyme-based fluorescent sensors that specifically detect and image Fe2⁺ and Fe3⁺ ions in living cells, enabling the study of iron dynamics in biological processes and diseases like Alzheimer’s. Background Iron ions, specifically Fe2⁺ and Fe3⁺, are essential for numerous biological processes, including oxygen transport, DNA synthesis,...
Published: 1/31/2025   |   Inventor(s): Yi Lu, Seyed-Fakhreddin Torabi, Yuting Wu, Ryan Lake, Zhenglin Yang, Peiwen Wu, Whitney Lewis, Jacqueline Van Stappen, Xiangli Shao
Keywords(s):  
Category(s): Life sciences > Biomaterials
DNA aptamer technology for Coenzyme A detection and cellular imaging
Researchers developed a DNA aptamer that specifically targets Coenzyme A, enabling easy and accurate detection in cells. This technology is more specific and simpler than current methods, supporting diagnostics, research, and treatments for diseases involving CoA imbalance. Background The field of biochemical research and medical diagnostics increasingly...
Published: 1/14/2025   |   Inventor(s): Yi Lu, Whitney Lewis, Yuan Ma
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug screening, Life sciences > Research tools > Tool/assay/screening platform
HIGH OUTPUT, FLEXIBLE PIEZOELECTRIC DEVICES
Princeton Docket # 10-2585 Researchers at Princeton have developed a new design for highly flexible, high output piezoelectric assemblies. Princeton is seeking an industrial partner to commercialize this technology. Current and past devices have relied on low output piezoelectric compounds and mechanical...
Published: 4/10/2025   |   Inventor(s): Michael McAlpine, Yi Qi
Keywords(s):  
Category(s): Mechanical/Electrical Engineering
Acquisition – Software to Control Acquisition of Images for Near-Earth Object Survey Operations
The Acquisition subsystem in the Catalina Sky Survey (CSS) software suite manages the operation of telescopes and instruments to capture data on asteroids and Near-Earth Objects (NEOs). Once areas of the sky are selected for observation, Acquisition takes over, accepting the input from the Planner subsystem and coordinating the telescope, camera, and...
Published: 12/9/2024   |   Inventor(s): A Departmental Work
Keywords(s):  
Category(s): Technology Classifications > Software & Information Technology > Open Source, Technology Classifications > Software & Information Technology
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