Search Results - huw+davies

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Cost-Effective Catalysts for Industrial Chemical Applications
Application A cost-effective catalyst for industrial chemical applications as an alternative to expensive rhodium-dependent dirhodium catalysts. Key Benefits Alternative catalysts to dirhodium using a straightforward synthesis process. Preliminary data show the ability to self-assemble in a similar manner to dirhodium compounds. Significantly...
Published: 7/30/2024   |   Inventor(s): Huw Davies, Joshua Sailer, Jack Sharland, Bo Wei
Keywords(s): Chemistry
Category(s): TechPub Algolia > Non-Therapeutics
CFTR Modulators for Treating Rare Forms of Cystic Fibrosis
Application Small molecules to treat cystic fibrosis and other pulmonary diseases. Key Benefits Rescue rare variants of CFTR gene. Serve as PDE4 inhibitors with strong anti-inflammatory effects. Market Summary Cystic fibrosis (CF) is a progressive, genetic disorder that arises from mutations in the cystic fibrosis transmembrane conductance...
Published: 8/22/2024   |   Inventor(s): Eric J. Sorscher, Jeong Hong, Haian Fu, Yuhong Du, Huw Davies, Andras Rab, Candela Manfredi, Xun Yang, Zhi Ren
Keywords(s): Rare/Orphan Diseases, Respiratory, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Chimeric Molecule for the Treatment of Depression
Application Small molecules for treating depression and/or depression associated with cancer/chemotherapy. Key Benefits Potentially a dual mechanism compound – working via monoamine reuptake inhibition and HDAC inhibition (epigenetic modification). Quicker acting compound compared to current therapies in the market. Works better than the...
Published: 8/22/2024   |   Inventor(s): Hyunsuk Shim, Huw Davies, Hyun Min Park, Yoon Hyeun Oum
Keywords(s): Neuroscience/Pain, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Cyclopropylamide Derivatives for Pain Management
ApplicationSmall molecules that can be used in the treatment of neuropathic pain. Key BenefitsCyclopropylamines have shown reduced side effects compared to other SNRIs for the treatment of neuropathic pain. Cyclopropylamine derivatives are more potent than other SNRI medication. Technical SummaryNeuropathic pain is a chronic/persistent state resulting...
Published: 7/30/2024   |   Inventor(s): Huw Davies, Spandan Chenna Madhavuni, Thomas Martin, Steven Childers
Keywords(s): Neuroscience/Pain, Small Molecule
Category(s): TechPub Algolia > Therapeutics
Chiral Catalyst for Enantioselective Reactions of Aryl- and Styryldiazoacetates
Application Catalysis of highly enantioselective cyclopropanations, tandem cyclopropanation/Cope rearrangements and combined C-H functionalization/Cope rearrangement reactions. Key Benefits Exhibits good tolerance to large ester groups for electron-withdrawing in high asymmetric induction. Efficient reactions in dichlormethane allowing broader...
Published: 7/30/2024   |   Inventor(s): Changming Qin, Jorn Hansen, Huw Davies
Keywords(s): Chemistry, Enzyme/Protein
Category(s): TechPub Algolia > Non-Therapeutics, TechPub Algolia > Research Tools