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Search Results - richard+compans
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Boosting Immunogenicity of Vaccines Using Saponins and Agonists of the Intracellular STING Pathway
Application Vaccine formulation of an activator of the stimulator of interferon genes (STING) pathway and saponin adjuvant for enhanced protection of aged population. Key Benefits Significantly improved protective immunity of vaccine in the aged. More efficient than the current methods of influenza vaccination of population 65 years of age or...
Published: 10/28/2024
|
Inventor(s):
Elena Vassilieva
,
Richard Compans
Keywords(s):
Immunology/Inflammation
,
Microbiology/Infectious Diseases
,
Small Molecule
Category(s):
TechPub Algolia > Vaccines
Membrane-anchored Fusokine as Vaccine Adjuvant to Prevent Viral Infection
Application GIFT4 anchored to virus-like particles (VLPs) as a prophylactic vaccine adjuvant to prevent chronic viral infections including HIV, HBV, HPV and influenza. Key Benefits GIFT4-containing VLPs induce higher antibody response than non-adjuvanted VLPs. Effectively induce strong mucosal immune response. Market Summary Currently, there...
Published: 7/30/2024
|
Inventor(s):
Baozhong Wang
,
Richard Compans
,
Jacques Galipeau
,
Jiusheng Deng
Keywords(s):
Enzyme/Protein
,
Immunology/Inflammation
,
Microbiology/Infectious Diseases
Category(s):
TechPub Algolia > Vaccines
Novel Vaccine Antigen Presentation Platforms
Application Combined antigen-adjuvant virus-like particle (VLP) vaccine platform for enhanced immune response. Key Benefits Chimeric VLPs (cVLPs) contain both antigen and adjuvant, thereby enhancing both cellular and humoral responses. cVLPs are safer than live replicating vectored vaccines because of their lack of infectivity. The cVLP manufacturing...
Published: 9/26/2024
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Inventor(s):
Baozhong Wang
,
Fu Shi Quan
,
Martin Moore
,
Richard Compans
,
Alan Aderem
,
Ioanna Skountzou
,
Jadranka Bozja
Keywords(s):
Immunology/Inflammation
,
Microbiology/Infectious Diseases
Category(s):
TechPub Algolia > Vaccines
Repurposed Kinase Inhibitors as Vaccine Adjuvants
Application Repurposed, small molecule kinase inhibitors, such as epidermal growth factor receptor (EGFR) inhibitors, as topical vaccine adjuvants. Key Benefits Improves immune response and efficacy of vaccines and vaccine candidates. Employs compounds that are already approved for human use. Market Summary In order to create long lasting protection...
Published: 10/17/2024
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Inventor(s):
Brian Pollack
,
Richard Compans
,
Joanna Pulit-Penaloza
,
Ioanna Skountzou
Keywords(s):
Immunology/Inflammation
,
Microbiology/Infectious Diseases
,
Repurposed Drug
,
Small Molecule
Category(s):
TechPub Algolia > Therapeutics
,
TechPub Algolia > Vaccines
HIV Vaccine Using Virus-Like Particles (VLPs)
Application VLPs containing modified HIV Env have been developed for an AIDS vaccine, capable of inducing cellular and humoral immune responses; including neutralizing activities. Key Benefits VLPs are safer than live replicating vectored vaccines because of their lack of infectivity, allowing for use in immunocompromised patients. HIV VLPs extract...
Published: 10/28/2024
|
Inventor(s):
Richard Compans
,
Beatrice Hahn
,
Gale Smith
Keywords(s):
Microbiology/Infectious Diseases
Category(s):
TechPub Algolia > Vaccines