Search Results - sars

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Anti-Viral Polypeptide Griffithsin: Compounds, Compositions, and Methods of Use
Abstract: This technology describes additional methods of using the griffithsin anti-viral polypeptides described in related NCI invention (reference number E-106-2003).  Specifically, this invention describes the use of GRFT to inhibit viral infection of hepatitis C viral infection, a severe acute respiratory syndrome (SARS) viral infection, an H5N1...
Published: 4/8/2024   |   Inventor(s): Barry O'Keefe, James McMahon, Toshiyuki Mori
Keywords(s): Anti-Viral, Corona virus, Ebola, Griffithsin, INFLUENZA, O’Keefe, SARS
Category(s): TherapeuticArea > Infectious Disease, Collaboration Sought > Collaboration, Application > Therapeutics, Collaboration Sought > Licensing
Griffithsin-Based Anti-viral Therapeutics with Improved Stability and Solubility
Abstract: Griffithsin is a potent anti-viral protein with activity against HIV, HCV, Sars, HSV 1 & 2 and other viruses.  It is active against HIV and HCV at picomolar concentrations.  Griffithsin is moving into clinical trials as an anti-HIV microbicide. Based on the structure of griffithsin and the necessities of pharmaceutical product development...
Published: 7/16/2024   |   Inventor(s): Barry O'Keefe, Kenneth Palmer, Tinoush Moulaei, Lisa Rohan, Joshua Fuqua, Lindsay Kramzer
Keywords(s): Anti-Viral, cnidarin, Griffithsin, HCV, HIV, HSV, SARS
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease
An Anti-Viral Polypeptide: Griffithsin
Abstract: Virus entry into a susceptible host cell is the first step in the formation of all viral diseases. Controlling viral infections by disrupting viral entry is advantageous for antibody-mediated neutralization by the host’s immune system and as a preventive and therapeutic antiviral strategy. Plant-derived carbohydrate-binding proteins...
Published: 4/8/2024   |   Inventor(s): Michael Boyd, Toshiyuki Mori, Barry O'Keefe
Keywords(s): Griffithsin, O'Keefe, SARS, Severe acute respiratory syndrome
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing
Use of Modified Peptide Nucleic Acids for Visualizing DNA
The compounds described in this technology may be useful in the development of nucleic acid detection kits for various pathogens. Technologies for genomic detection most commonly use DNA probes to hybridize to target sequences, and require the use of Polymerase Chain Reaction (PCR) to amplify target sequences. Replacing the DNA probe with peptide nucleic...
Published: 10/28/2024   |   Inventor(s): Daniel Appella
Keywords(s): 2, Acid, Acids, Anthrax, APPLICATIONS, Cross-Coupled, Cyclopentan, Detection, Diamine-modified, Gamma-lysine, Modified, Nucleic, Patent Category - Chemistry, PATHOGENS, Peptide, Probes, SARS, Severe acute respiratory syndrome, Synthesis, Trans-1, YXXXXX
Category(s): Collaboration Sought > Collaboration
Methods and Compositions for the Inhibition of SARS-CoV Replication Propagation and Transmission
Available for licensing and commercial development is a method of inhibiting SARS-CoV replication, propagation and transmission using 2-cyano-3,12-dioxooleana-1,9-dien-28-oic (CDDO). Severe acute respiratory syndrome (SARS) is an infectious atypical pneumonia that has recently been recognized in patients in 32 countries and regions. The atypical pneumonia...
Published: 10/28/2024   |   Inventor(s): Sharon Wahl, Gang Peng
Keywords(s): (4)r syndrome, C syndrome, Chromosome 4 ring syndrome, Chromosome 6 ring syndrome, Chromosome 7 ring syndrome, DB4BXX, DBXXXX, DXXXXX, G syndrome, Hypertelorism with esophageal abnormality and hypospadias, N syndrome, R(6) syndrome, R(7) syndrome, SARS, Severe acute respiratory syndrome, Syndrome X, W syndrome, W syndrome; Syndrome W
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease