Search Results - guangzhao+mao

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Using Nanotechnology to Target Aggressive Cancers
A modified gold nanoparticle is used to target aggressive triple negative breast cancer and melanoma by inhibiting RAD6 which is overexpressed in aggressive and chemoresistant cancers. Technology Summary This technology utilizes gold nanoparticles (GNPs) conjugated with a small molecule inhibitor (SMI#9) designed to target RAD6, a protein overexpressed...
Published: 9/15/2025   |   Inventor(s): Malathy Shekhar, Guangzhao Mao, Yanhua Zhang
Keywords(s): Breast Cancer, Nanotechnology
Category(s): Life Science, Oncology, Drug Delivery, Therapeutics, Cancer, Nanomaterials
DNA Nanocaged Enzymes
Compartmentalization increases the overall activity and specificity of encapsulated enzymes by protecting the enzymes, maintaining a high concentration of enzymes and substrates, and promoting substrate channeling. While there have been artificial enzymatic particles that have been created using compartmentalization by virus-like proteins, liposomes,...
Published: 2/13/2025   |   Inventor(s): Jinglin Fu, Hao Yan, Neal Woodbury, Zhao Zhao
Keywords(s): Bioanalysis, Catalysis, Enzymes
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors
Targeted Drug Delivery for Spinal Cord Injury
Technology Summary: WSU researchers have developed a new nanoparticle-drug conjugate for treating cervical spinal cord injury (SCI) that can restore respiratory function to the paralyzed hemi diaphragm. Using the nano-conjugate enables targeted delivery of the drug directly to the respiratory centers resulting in dramatically lower effective dosages...
Published: 9/15/2025   |   Inventor(s): Harry Goshgarian, Guangzhao Mao, Yi Zou, Sunxi Wang
Keywords(s): Central Nervous System, Drug Delivery, Neuroscience, Therapeutics
Category(s): Therapeutics, Life Science, Drug Delivery, Nanomaterials, Neurological disorders, Receptors/targets