Search Results - roger+johnson

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Mitochondrial-Targeted Peptide Modulators of Delta Protein Kinase C Interaction with the d-subunit of F1Fo ATP Synthase/ATPase as Therapeutics Against Cardiac Injury
Current State of the Art: Current clinical therapy for heart attack victims focuses on the rapid restoration of blood flow by thrombolysis, angioplasty, stenting and when appropriate surgical coronary artery bypass grafts. Problems with the Current Art: The majority of cardiac cell death associated with a heart attack actually occurs during the...
Published: 4/29/2020   |   Inventor(s): John Johnson, Tiffany Tuyen Nguyen, Mourad Ogbi
Keywords(s): Cardiovascular, Heart Attack, Therapeutics
Category(s): Therapeutics
Biocompatible gel formulation
Single-cell and cell cluster optical tomography, or Cell-CT, has found increasing application in life sciences basic research. Two limitations to its use in this area are that it can image only fixed cells, and the lack of thixotropic gels that can support live cells and also satisfy refractive index constraints. Researchers at the Biodesign Institute...
Published: 2/23/2023   |   Inventor(s): Roger Johnson, Fengyu Su, Laimonas Kelbauskas, Vivek Nandakumar, Yanqing Tian, Deirdre Meldrum
Keywords(s): Bio-Technology, Drug Screening, Materials, Medical Devices and Imaging, Therapeutics
Category(s): Biomaterials, Life Science (All LS Techs), Medical Imaging
Fluorescent Potassium Ion Sensors
The accurate measurement of potassium ion levels in biological samples is essential given the impact such ion levels have on many aspects of homeo-stasis. Normal potassium levels are important for the maintenance of heart and nervous system function. Traditionally, potassium ions have been measured in plasma or serum using ion-selective electrodes,...
Published: 2/23/2023   |   Inventor(s): Yanqing Tian, Deirdre Meldrum, Xianfeng Zhou, Fengyu Su, Roger Johnson, Cody Youngbull
Keywords(s): Agriculture and Animal Science, Bio-Technology, Environmental, Materials and Electronics, Medical Devices and Imaging, Therapeutics
Category(s): Medical Diagnostics/Sensors, Chemical/Biological Sensors, Life Science (All LS Techs)
Endoscope for Analyte Consumption Rate Determination with Single Cell Resolution for In Vivo Applications
Determination of consumption/secretion rates of single-cell resolution has great potential for delivering detailed insights into early onset and development of various disease states as well as drug and stimulus response. Due the lack of sensitivity of current technologies, this information is difficult to obtain. Single cell measurements in vivo are...
Published: 2/23/2023   |   Inventor(s): Deirdre Meldrum, Laimonas Kelbauskas, Jeff Houkal, Roger Johnson, Yanqing Tian, Cody Youngbull
Keywords(s): Bio-Technology, Drug Screening, Medical Devices and Imaging, Therapeutics
Category(s): Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Imaging
Chips and Fabrication Methods for Capture and Rotation of Live Single Cells or Cell Clusters
High-dimensional single cell visualization technologies, such as live-cell computed tomography (CT), are redefining the way we view and understand biological systems, particularly when identifying and analyzing cancer cells. Some cell defects on the surface or in the interior of a cell just can't be properly evaluated in two dimensional microscopy....
Published: 2/23/2023   |   Inventor(s): Deirdre Meldrum, Roger Johnson, Iniyan Soundappa Elango, Andrew Shabilla, Hong Wang, Matthew Stanley, Jakrey Myers, Laimonas Kelbauskas, Dean Smith, Pimwadee Limsirichai
Keywords(s): Bio-Technology, Drug Screening, Environmental, Materials and Electronics, Medical Devices and Imaging
Category(s): Life Science (All LS Techs), Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Imaging