Search Results - therapeuticarea

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HLA-class II-restricted T Cell Receptors for PIK3CA “Hotspot” Mutations, E545K and N345K
Summary: The National Cancer Institute (NCI) seeks co-development partners and/or licensees for a collection of T cell receptors (TCRs) that specifically target PIK3CA mutations to treat patients with tumors expressing these mutations in the context of HLA-DPA1*01:03:01, HLA-DPB1*04:01:01 or HLA-DRB1*04:01. Description of Technology: Phosphatidylinositol-4,5-biphosphate...
Published: 11/10/2024   |   Inventor(s): Steven Rosenberg, NIkolaos Zacharakis, S M Rafiqul Islam, Samantha Seitter, Maria Parkhurst, Frank Lowery
Keywords(s):  
Category(s): TherapeuticArea, TherapeuticArea > Oncology, TherapeuticArea > Immunology, Collaboration Sought > Collaboration, Application > Therapeutics
Pigment Epithelium-Derived Factor Peptides and Use for Treating Retinal Degeneration
Summary: The National Eye Institute (NEI) seeks research co-development partners and/or licensees for the development of an eyedrop formulation and/or AVV2-based delivery system to deliver the 17-mer [H105A] peptide to treat retinal degeneration. Description of Technology: Retinitis pigmentosa (RP) is one of the most common inherited retinal...
Published: 4/8/2024   |   Inventor(s): S. Patricia Becerra
Keywords(s):  
Category(s): Application, TherapeuticArea, TherapeuticArea > Eye / Ear / Nose / Throat, Collaboration Sought > Collaboration
T Cell Receptors Targeting the KRAS G13D Mutation in the Context of HLA-A11:01 for Research Use
Summary: The National Cancer Institute (NCI) has identified HLA-A11:01-restricted T Cell Receptors (TCRs) targeting the KRAS G13D mutation. The NCI seeks licensees for the use of these TCRs in research. Description of Technology: Tumor-specific mutated proteins can create immunogenic, mutation-containing “neoepitopes” which are attractive...
Published: 4/8/2024   |   Inventor(s): Catherine Ade, Zhiya Yu, Matthew Sporn, James Yang, Kenichi Hanada
Keywords(s):  
Category(s): TherapeuticArea, Application, Application > Research Materials, Collaboration Sought > Licensing