Search Results - chen+xiaoming

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Telomere assay for the detection of alternative lengthening of telomere (ALT) activity in cells
PAGE TITLE Overview PAGE SUMMARY Executive Statement: A unique tool for distinguishing cancer cells based on telomere maintenance mechanisms, providing potential biomarkers for cancer subtypes and therapeutic responses. Description: This technology provides detailed telomere profiling from individual chromosomes, capable of differentiating...
Published: 6/28/2024   |   Inventor(s): Ming Xiao
Keywords(s):  
Category(s): Life Sciences, Medical Devices & Diagnostics, Medical Devices & Diagnostics > MDD: Diagnostic Tests, Pharmaceuticals & Therapeutics > Pharma: Gene Therapy, Pharmaceuticals & Therapeutics > Pharma: Cellular Therapy, Pharmaceuticals & Therapeutics > Pharma: Genome Engineering, Research Tools & Materials
Quantification of On-off target gene editing by optical mapping
PAGE TITLE Overview PAGE SUMMARY Executive Statement: A revolutionary methodology for quantifying on-target and off-target gene editing activity using CRISPR-Cas9 and optical mapping. Description: This technology comprises a single-molecule optical mapping strategy using CRISPR-Cas9 to fluorescently label the modified genes. The method involves...
Published: 6/28/2024   |   Inventor(s): Ming Xiao, Yilin Wang, Lahari Uppuluri
Keywords(s):  
Category(s): Life Sciences, Medical Devices & Diagnostics, Medical Devices & Diagnostics > MDD: Diagnostic Tests, Research Tools & Materials, Pharmaceuticals & Therapeutics > Pharma: Cellular Therapy, Pharmaceuticals & Therapeutics > Pharma: Gene Therapy, Pharmaceuticals & Therapeutics > Pharma: Genome Engineering
Multicolor whole-genome mapping for genetic analysis
PAGE TITLE Overview PAGE SUMMARY Executive Statement: A novel method for precise genome mapping and sequencing using Cas9-mediated labeling within nanochannels. Description: This technology is a method for mapping a whole genome using a universal multi-color mapping strategy in nanochannels that combines a conventional sequence-motif labeling...
Published: 6/20/2024   |   Inventor(s): Ming Xiao, Lahari Uppuluri
Keywords(s):  
Category(s): Life Sciences, Medical Devices & Diagnostics, Medical Devices & Diagnostics > MDD: Diagnostic Tests, Pharmaceuticals & Therapeutics > Pharma: Cellular Therapy, Pharmaceuticals & Therapeutics > Pharma: Gene Therapy, Pharmaceuticals & Therapeutics > Pharma: Genome Engineering, Research Tools & Materials
Linked-read sequencing library preparation
PAGE TITLE Overview PAGE SUMMARY Executive Statement: Innovative methods for generating sequence-linked DNA fragments for high-quality, low-cost genome sequencing. Description: This technology describes a novel strategy to construct a long-read sequencing library such that adjacent fragments are linked with end-terminal duplications. The...
Published: 6/28/2024   |   Inventor(s): Ming Xiao, Lahari Uppuluri
Keywords(s):  
Category(s): Life Sciences, Medical Devices & Diagnostics > MDD: Diagnostic Tests, Pharmaceuticals & Therapeutics > Pharma: Genome Engineering, Pharmaceuticals & Therapeutics > Pharma: Gene Therapy, Pharmaceuticals & Therapeutics > Pharma: Cellular Therapy, Research Tools & Materials
Single molecule real-time long DNA mapping and sequencing
PAGE TITLE Overview PAGE SUMMARY Executive Statement: The invention offers an innovative way to immobilize and optically map/sequence oligonucleotides on a micropatterned substrate for efficient large-scale genomic assembly. Description: This technology presents a method for immobilizing and linearizing oligonucleotides on a micropatterned...
Published: 6/20/2024   |   Inventor(s): Ming Xiao, Dharma Varapula, Eric LaBouff, Moses (hongseok) Noh
Keywords(s):  
Category(s): Medical Devices & Diagnostics, Computing, Software, Analytics & Information Technology > Computing: Bioinformatics, Medical Devices & Diagnostics > MDD: Diagnostic Tests, Life Sciences, Pharmaceuticals & Therapeutics > Pharma: Cellular Therapy, Pharmaceuticals & Therapeutics > Pharma: Gene Therapy, Pharmaceuticals & Therapeutics > Pharma: Genome Engineering, Research Tools & Materials
CRISPR-Cas9 Labeling of Human Genomic DNA for Telomere Length Measurement
PAGE TITLE Overview PAGE SUMMARY Executive Statement: An innovative method for the precise detection and measurement of individual telomere lengths that can be correlated to specific chromosomes. Description: This technology provides a method for detecting the length of individual telomeres in genomic DNA using a unique combination of guide...
Published: 4/6/2024   |   Inventor(s): Ming Xiao, Jennifer McCaffrey
Keywords(s):  
Category(s): Medical Devices & Diagnostics, Medical Devices & Diagnostics > MDD: Diagnostic Tests, Life Sciences, Pharmaceuticals & Therapeutics > Pharma: Cellular Therapy, Pharmaceuticals & Therapeutics > Pharma: Gene Therapy, Pharmaceuticals & Therapeutics > Pharma: Genome Engineering, Pharmaceuticals & Therapeutics > Pharma: Oncology
Nanopore Tweezer System for Protein Kinase Allosteric Drug Screening
­ PRODUCT OPPORTUNITIES AND END-USE APPLICATIONS • Nanopore-tweezer-based system for efficient kinase allosteric drug screening ADVANTAGES • Label-free method • Capable of identifying both allosteric inhibitors and activators • Capable of distinguishing active-site inhibitors from allosteric...
Published: 8/3/2023   |   Inventor(s): Min Chen, Fanjun Li
Keywords(s):  
Category(s): Biotechnology, Life Sciences, Research tools
Nanopore-based Sensors for Antibody Screening Applications
PRODUCT OPPORTUNITIES AND END-USE APPLICATIONS • Nanopore-based antibody screening system • Nanopore sensors for antibody detection and identification • Antibody screening in hybridoma-based antibody production • Real-time monitoring of antibody production in cell culture ADVANTAGES •...
Published: 6/26/2023   |   Inventor(s): Min Chen, Joshua Foster, Minji Kim, Matthew Moore
Keywords(s):  
Category(s): Devices & sensors, Life Sciences, Research tools
Novel Multi-Omics Aging Clock
­A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...
Published: 3/12/2024   |   Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools
Autonomous Drone for railroad track inspection
Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...
Published: 3/15/2023   |   Inventor(s): Yu Qian, Yi Wang, Chen Chen
Keywords(s): autonomous drone, flight control, image processing, railroad track inspection, self-navigation
Category(s): Engineering and Physical Sciences
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