PAGE TITLE
Overview
PAGE SUMMARY
A revolutionary methodology for quantifying on-target and off-target gene editing activity using CRISPR-Cas9 and optical mapping.
This technology comprises a single-molecule optical mapping strategy using CRISPR-Cas9 to fluorescently label the modified genes. The method involves scanning the whole genome, locating molecules with modified genes, and quantifying gene modification events for both on-target and off-target gene modification.
ADVANTAGES
TITLE:Key Advantages
Provides an efficient, less time-consuming, and less costly alternative to Whole Genome Sequencing (WGS)
Allows for unbiased detection and true off-target gene editing frequency
Capable of quantifying less than 1% of gene modification events
Problem Solved
TITLE:Problems Solved
Solves the inefficient, expensive, and impractical nature of Whole Genome Sequencing (WGS)
Overcomes the limitations of biased detection in existing target enrichment sequencing protocols
APPLICATIONS
TITLE: Market Applications
Potential to revolutionize gene editing research in genomics
Useful in therapeutics for genetic diseases where precise gene editing is required
Could be essential in agricultural biotechnology for crop improvement
IP STATUS
Intellectual Property and Development Status
United States Provisional filed
Commercialization Opportunities
This invention is part of a larger portfolio of technologies available for licensing and commercialization around TOOLS FOR GENOMIC APPLICATIONS POWERED BY CRISPR/CAS9 BASED DNA LABELING
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Contact Information
For Intellectual Property and Licensing inquiries
Tanvi Muni, PhD
Licensing Manager,
Drexel Applied Innovation
Office of Research and Innovation
3250 Chestnut Street, Ste. 3010 Philadelphia, PA 19104
Phone:267-359-5640
Email:tanvi.muni@drexel.edu
Inventor information
Ming Xiao, PhD
Professor School of Biomedical Engineering, Science and Health Systems
Phone:215-895-2690
Email:mx44@drexel.edu
Inventor Webpage