PAGE TITLE
Overview
PAGE SUMMARY
The invention offers an innovative way to immobilize and optically map/sequence oligonucleotides on a micropatterned substrate for efficient large-scale genomic assembly.
This technology presents a method for immobilizing and linearizing oligonucleotides on a micropatterned substrate. It also describes its associated chemistry for mapping and sequencing DNA. The invention addresses the need for new devices and methods to stretch single DNA molecules and to immobilize and linearize oligonucleotides for efficient large-scale genomic assembly.
ADVANTAGES
TITLE:Key Advantages
Efficient and accurate mapping/sequencing of DNA sequences
Ability to generate super-long DNA sequencing and mapping reads
Resolves the limitations of traditional mapping and sequencing technologies
Problem Solved
TITLE:Problems Solved
Labor-intensive and resource-heavy traditional DNA mapping and sequencing
Limited length of linearized DNA for efficient large-scale genome assembly
APPLICATIONS
TITLE: Market Applications
Genome mapping and sequencing
Diagnostic testing for DNA-based diseases
Biomedical research
IP STATUS
Intellectual Property and Development Status
United States Patent Pending- Publication #US20210033606A1 - DNA mapping and sequencing on linearized DNA molecules
PUBLICATIONS
References
Pubinfo should be the citation for your publication. Publink is the full url linking to the publication online or a pdf.
Nature Scientific Reports 2019: A micropatterned substrate for on-surface enzymatic labelling of linearized long DNA molecules
Commercialization Opportunities
This invention is part of a larger portfolio of technologies available for licensing and commercialization around TOOLS FOR GENOMIC APPLICATIONS POWERED BY CRISPR/CAS9 BASED DNA LABELING
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Contact Information
For Intellectual Property and Licensing inquiries
Tanvi Muni, PhD
Licensing Manager,
Drexel Applied Innovation
Office of Research and Innovation
3250 Chestnut Street, Ste. 3010 Philadelphia, PA 19104
Phone:267-359-5640
Email:tanvi.muni@drexel.edu
Inventor information
Ming Xiao, PhD
Professor School of Biomedical Engineering, Science and Health Systems
Phone:215-895-2690
Email:mx44@drexel.edu
Inventor Webpage