This innovative technology employs a combination inoculum of the plant growth-promoting rhizobacterium Azospirillum brasilense Sp7 and the nucleoside compound cytidine to coat crop seeds. This treatment significantly improves root architecture, increases bacterial colonization in the rhizosphere, and boosts plant resistance to diseases such as those caused by Pseudomonas syringae in tomatoes. The combination synergistically enhances lateral root growth and reduces disease symptoms without diminishing pathogen presence, offering an environmentally friendly alternative to chemical pesticides. The technology is applicable across diverse crops including peas, soybeans, and tomatoes, with proven benefits in promoting plant growth, nutrient uptake, and biocontrol of phytopathogens.