Search Results - david+brown

3 Results Sort By:
Human Artificial Chromosome Generation Technology
Technology allowing efficient formation, delivery, isolation, and enrichment of single-copy Human Artificial Chromosome (HAC) for use in research, plant production, gene and cell therapy and more. Problem: Existing gene-editing techniques have limitations due to their reliance on viruses for delivery, restricting their packaging capacities. A more potent...
Published: 9/19/2025   |   Inventor(s): Ben Black, Craig Gambogi, John Glass, David Brown, Gabriel Birchak
Keywords(s): Bioengineering, Gene Editing, Gene Therapy, Genetic Disorders, Platform Technology
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
RECONSTITUTION OF SPLIT-HALOTAG VIA ORTHOGONAL TAG BINDING DOMAINS
RECONSTITUTION OF SPLIT-HALOTAG VIA ORTHOGONAL TAG BINDING DOMAINS Researchers at UCSF have developed a method using split HaloTags to tag multiple proteins in a single assay and measure their interactions. Due to new technologies such as CRISPR/Cas9 gene editing, it is now easier to modify DNA than at any other point in human history. One of the...
Published: 5/18/2023   |   Inventor(s): David Brown, Suraj Makhija, Bo Huang
Keywords(s): FACS, HaloTag, Knock-In Cell Lines, Protein Fragment, Self-Complementing Protein Fragments, Split Protein System
Category(s): Technology Classifications > Biology
Small Molecule Inhibitors of NADPH Oxidase 4 (NOX4) Signaling
Application Small molecule inhibitors of NOX4 signaling with a wide array of therapeutic potential. Key Benefits Small molecule inhibitors of NOX4 signaling. Low cytotoxicity. Market Summary The NADPH oxidase 4 (NOX4) has gained considerable and growing attention during the past years because of its potential key involvement in a variety of...
Published: 7/22/2025   |   Inventor(s): Bernard Lassegue, Kathy Griendling, David Brown, Qian Xu, Osman Guner, J. Phillip Bowen, Amol Kulkarni, E. Blake Watkins
Keywords(s): Small Molecule
Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Drug Discovery