Search Results - cytotoxic

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Defensin-Based Therapeutics for the Treatment of Pulmonary Disease
Investigators at the National Heart, Lung and Blood Institute have developed modified defensins that are resistant to degradation, have improved characteristics compared to unmodified defensins, and are promising candidates for pulmonary disease therapeutics. Defensins are small cationic peptides that defend the lung against pathogenic microorganisms...
Published: 10/28/2024   |   Inventor(s): Joel Moss
Keywords(s): ADP-ribose, ADP-ribose-arginine, ADP-RIBOSYLARGININE, ADP-ribosylation, AIRWAY, Arginines, ASTHMA, BBXXXX, cytotoxic, CYTOTOXICITY, DBXXXX, defensin, Defensins, DXXXXX, HNP-1, human neutrophil peptide 1, IB4XXX, IBXXXX, Inflammation, IXXXXX, neutrophil, Patent Category - Biotechnology, Pulmonary, PULMONARY FIBROSIS
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Pulmonology, Application > Diagnostics, Application > Research Materials
N-Heterocyclic Carbene Aptamers that Target Drug Delivery to Specific Cancer Cells
Cytotoxic Therapy Targets Malignancies, Avoiding Healthy Cells and Negative Side Effects Caused by Heavy Metal Buildup in OrgansThese aptamers, conjugated with N-heterocyclic carbene metal complexes, deliver therapeutic doses of the cytotoxic metal ion to targeted cancer cells. These complexes avoid toxicity to healthy cells while being highly effective...
Published: 6/27/2021   |   Inventor(s): Adam Veige, Mary Garner, Weijia Niu
Keywords(s): Aptamer crosslinker, aptamers, Cancer Cells Targeting, Cancer Drug Delivery, Cancer Drugs, Cancer Therapeutics, Cancer Therapeutics: Small Molecule, carbene, Cytotoxic, metal ion
Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Human Health Care > Therapeutics