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Inhibition of a Cholesterol Metabolism Gene for Effectively Treating Sepsis
Pharmacologically Blocking Specific Cholesterol Gene to Treat and Reduce Early Death from Sepsis This cholesterol metabolism gene is upregulated in sepsis patients with poor prognoses, and its inhibition shows promise as an effective treatment. Sepsis is the body’s extreme immune response to an existing infection, giving rise to an enhanced chain...
Published: 1/22/2024   |   Inventor(s): Faheem Guirgis, Vinitha Jacob, Jordan Shavit, Srinivasa Reddy
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Human Health Care > Others
Use of Quercetin and Related Flavonoids for the Treatment of Myotonic Dystrophy Types 1 and 2
A novel flavonoids-based therapeutic strategy for the treatment of myotonic dystrophy and potentially repeat expansion disorders. Background: Myotonic dystrophy (DM) is the most common form of adult muscular dystrophy. It is a multisystemic disorder affecting nearly all organs including muscles, brain, heart, eyes, and the GI tract, among others....
Published: 3/12/2024   |   Inventor(s): John Berglund, Subodh Mishra, Kaalak Reddy, John Cleary
Keywords(s): drug discovery, drug efficacy, myotonic dystrophy, RNA, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Healthcare, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
PEGylation of the Human Galectin-3C Protein for Improving Biologic Therapeutic Use
Increases the Stability and Robustness of the Galectin-3C Protein PEGylation of the carbohydrate recognition domain of human Galectin-3 (Gal3C) increases the stability and robustness of the protein, overcoming limitations hindering its biologic therapeutic use. Biologics are highly effective, targeted treatments for varying diseases, constituting approximately...
Published: 8/21/2023   |   Inventor(s): Matthew Eddy, Michael Harris, Amanda Pritzlaff
Keywords(s):  
Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Human Health Care > Therapeutics
Vaccine-pulsed Dendritic Cells as a Treatment for Aggressive Breast Cancers
Application Immunotherapy for HER2+ and triple-negative breast cancer. Key Benefits Autologous vaccine comprising patient-specific tumor antigens and immune stimulatory components against aggressive breast cancers. Prepared outside of the body and then administered to patients. Preclinical data indicate treatment decreases tumor growth and improves...
Published: 10/17/2024   |   Inventor(s): Periasamy (Selva) Selvaraj, Luis Munoz, Ramireddy Bommireddy, Christopher Pack, Shaker Reddy, Sampath Ramachandiran
Keywords(s): Immunology/Inflammation, Oncology, Women's Health
Category(s): TechPub Algolia > Therapeutics
Seatbelt System for Buses – Retrofit or New
PRODUCT OPPORTUNITIES This invention can provide the many buses that are currently operating without seatbelts a cost effective means to obtain an approved seatbelt system that can substantially extend the useful life of these buses. PRODUCT OPPORTUNITIES TECHNOLOGY DESCRIPTION A novel seatbelt system has been developed that...
Published: 8/3/2023   |   Inventor(s): Sundar Krishnamurty, Douglas Eddy, Anne Schewe, Conrad Zanzinger
Keywords(s):  
Category(s): Devices, Engineering
Transgenic Hspa2-Cre Mice for Studying Spermatogenesis and Male Infertility
HSPA2 is a member of the HSP70 family of heat-shock proteins that serve as molecular chaperones. Hspa2-cre expression mimics the spermatogenic cell-specific expression of endogenous HSPA2 within the testis, being first observed in leptotene/zygotene spermatocytes. Expression of the transgene is also detected at restricted sites in the brain, as occurs...
Published: 10/28/2024   |   Inventor(s): Edward Eddy
Keywords(s): Cells, Cre, EXPRESSED, Gene, Generation, Hspa2, IDXXXX, IXXXXX, Line, Mouse, PROMOTER, Recombinase, REGULATION, Spermatogenesis, Spermatogenic, TRANSGENIC
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Application > Research Materials, Application > Diagnostics
Hspa2 Knockout Mice for Study of Spermatogenesis and Male Infertility
HSPA2 is a member of the HSP70 family of heat-shock proteins that serve as molecular chaperones. Researchers discovered that HSPA2 protein is expressed in spermatogenesis during the meiotic phase. Spermatogenic cells lacking the HSPA2 protein arrest in mid-meiosis and undergo apoptosis. HSPA2 is present in the synaptonemal complex of wild-type mice...
Published: 10/28/2024   |   Inventor(s): Edward Eddy
Keywords(s): Deletion, Gene, Generation, Hsp70-2, Hspa2, IDXXXX, IXXXXX, KNOWN, Mouse, previously, Spermatogenesis, Strain, Targeted
Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Therapeutics, Application > Research Materials
All-Optical Multiplexer and De-multiplexer for Temporal Modes of Electromagnetic Radiation using Nonlinear Optical Cavities and Shaped Laser Pulses
University of Oregon Researchers: Michael Raymer, Dileep Reddy Patent: US10,871,699 issued on 12/22/2020 (UO-18-26) All-Optical Multiplexer and De-multiplexer for Temporal Modes of Electromagnetic Radiation using Nonlinear Optical Cavities and Shaped Laser Pulses. Technology Background/Definition of Problem:: A quantum pulse gate can be understood...
Published: 5/13/2024   |   Inventor(s): Michael Raymer, Dileep Reddy
Keywords(s): Science
Category(s): Communications, Engineering, Information Technology, Physical Science
Adaptive exercise-enabled proportional-derivative artificial pancreas control algorithm
Summary The current technology is an adaptive proportional-derivative (APD) control algorithm that provides automated delivery amounts of insulin and optionally glucagon to a person with type 1 diabetes using continuous glucose measurements (CGM) sensed from the person’s subcutaneous tissue. The APD algorithm includes a safety layer decision...
Published: 9/30/2022   |   Inventor(s): Peter Jacobs, Joseph Leitschuh, Jessica Castle, Joseph El Youssef, Seyed (Navid) Resalat, Ravi Reddy
Keywords(s): Software, Therapeutics
Category(s): Software, Therapeutics
Adaptive exercise-enabled model-predictive-control artificial pancreas control algorithm
Summary Artificial pancreas devices help maintain healthy glucose levels in patients with type 1 diabetes (T1D), but incidences of hypoglycemia are still common after episodes of eating, sleeping and exercise. Oregon Health & Science University researchers have developed an algorithm that features adaptive responses to these factors as well as...
Published: 12/5/2023   |   Inventor(s): Peter Jacobs, Joseph Leitschuh, Jessica Castle, Joseph El Youssef, Seyed (Navid) Resalat, Ravi Reddy
Keywords(s): Software, Therapeutics
Category(s): Software, Therapeutics
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