Search Results - zhenping+he

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Summary The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a class of novel aplithianine-derived small molecule analogs that compete with ATP for binding on a range of clinically relevant kinases including: Oncogenic gene fusion DNAJB1-PRKACA (PKADJ) Wild type protein kinase A (PKA) Protein kinase...

Published: 12/20/2024 | Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li

Keywords(s):

Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing

Reverse Thiazine Kinase Inhibitors

Published: 12/19/2024 | Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare / Neglected Diseases, Collaboration Sought > Licensing

Novel Kinase Inhibitory Aplithianines

Published: 12/20/2024 | Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li

Keywords(s):

Category(s): Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare / Neglected Diseases, Collaboration Sought > Collaboration, Collaboration Sought > Licensing

Method of Treating Obesity-Induced Glucose Intolerance and Liver Fibrosis (UCLA Case No. 2021-323)

UCLA researchers in the School of Engineering have discovered a novel method to treat obesity-induced glucose intolerance and liver fibrosis. BACKGROUND: The CDC reports that 41.9% of adults ages 20 and over are obese. An increased incidence of obesity also increases the rates of comorbidities such at type 2 diabetes mellitus (T2DM), non-alcoholic...

Published: 9/24/2024 | Inventor(s): Zhen Gu

Keywords(s): glucose intolerance, liver fibrosis, Nanoparticles, Notch signaling pathway, obesity

Category(s): Therapeutics > Metabolism And Endocrinology

Equanimity - Dynamic Physiology

This invention consists of a software package in combination with state-of-the-art hardware that is capable of continuously monitoring stress-related Heart Rate Variability (HRV). The software can recognize when HRV goes below a specified threshold and will prompt a yoga breathing exercise to increase HRV to healthier levels. The technology has the...

Published: 7/10/2024 | Inventor(s): John Allen, Richard Lane, Janet Roveda, Shu-Fen Wung, Ping Chang

Keywords(s):

Category(s): Technology Classifications > Software & Information Technology, Technology Classifications > Software & Information Technology > Mobile Application

A Transformer-Based Diffusion Probabilistic Model for Vital Signs Forecasting

The model proposed in this technology, Transformer-based Diffusion Probabilistic Model for Sparse Time Series Forecasting (TDSTF), is a novel deep-learning algorithm that can be used for vital signs forecasting, data synthesis, simulation, and digital twins. Trained and tested on data from over 46,000 patients, the TDSTF technology merges transformer...

Published: 8/23/2024 | Inventor(s): Ao Li, Ping Chang, Huayu Li, Janet Roveda

Keywords(s):

Category(s): Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Software & Information Technology > Web & Internet

A Broad-spectrum Biopesticide Strain with Plant Growth Promoting Capability

The Challenge Plant diseases can wipe out entire crops and historical plantings in a short period of time as shown by boxwood blight. Globally, these diseases pose increasing risks to food security and plant biosecurity. Current approaches to disease management depend largely on chemical protection. These approaches are not sustainable due to growing...

Published: 1/24/2024 | Inventor(s): Ping Kong

Keywords(s):

Category(s): Technology Classifications > Agriculture, Technology Classifications > Environment/Green Tech

Novel Anti-HIV Compounds Using Peptides or Peptide Mimetics

Abstract: The subject invention describes a new class of compounds (such as peptides or mimetics) that target viral RNAs and inhibit the viral life cycle by blocking the viral recognition process. More specifically, these compounds are the first against an RNA Target - currently there are no clinical drugs against RNA targets in the treatment of any...

Published: 4/8/2024 | Inventor(s): Yun-Xing Wang, Liu Yu, Ping Yu, Ina O'Carroll

Keywords(s): Anti-Viral, HIV

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease

Nucleic Acid Nanoparticles (NANP) and Methods of Using Same for Controlled Immunomodulation

Abstract: The technology is directed to compositions and methods of designing nucleic acid nanoparticles (NANPs) composed entirely of DNA, RNA, or DNA and RNA to achieve desirable immunostimulation and decrease undesirable effects on the immune system by changing the composition of the NANP. Benefits of the invention include the desirable activation...

Published: 4/8/2024 | Inventor(s): Kirill Afonin, Justin Halman, Marina Dobrovolskaia, Enping Hong

Keywords(s): CANCER, Dobrovolskaia, IMMUNE, Immunomodulation, Inflammation, Nucleic Acid Nanoparticle

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Therapeutics

Chemically Modified AMPA Receptor RNA Aptamers Designed for In Vivo Use

" RNA aptamers as glutamate agonists offer potential therapeutics for a range of neurological disorders RSS.HDBackground> Background: < Neurological disorders are increasingly recognized as major causes of death and disability worldwide. Nearly 500,000 cases of brain tumor, multiple sclerosis, and amyotrophic lateral sclerosis (ALS) are...

Published: 1/22/2024 | Inventor(s): Li Niu, Zhen Huang

Keywords(s): Technologies

Category(s): Technology Classifications > Screens and Assays, Technology Classifications > Research Tools and Reagents, Campus, Campus > University at Albany

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