Search Results - zhenping+he

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Method of Treating Obesity-Induced Glucose Intolerance and Liver Fibrosis (UCLA Case No. 2021-323)
UCLA researchers in the School of Engineering have discovered a novel method to treat obesity-induced glucose intolerance and liver fibrosis. BACKGROUND: The CDC reports that 41.9% of adults ages 20 and over are obese. An increased incidence of obesity also increases the rates of comorbidities such at type 2 diabetes mellitus (T2DM), non-alcoholic...
Published: 9/24/2024   |   Inventor(s): Zhen Gu
Keywords(s): glucose intolerance, liver fibrosis, Nanoparticles, Notch signaling pathway, obesity
Category(s): Therapeutics > Metabolism And Endocrinology
Equanimity - Dynamic Physiology
This invention consists of a software package in combination with state-of-the-art hardware that is capable of continuously monitoring stress-related Heart Rate Variability (HRV). The software can recognize when HRV goes below a specified threshold and will prompt a yoga breathing exercise to increase HRV to healthier levels. The technology has the...
Published: 7/10/2024   |   Inventor(s): John Allen, Richard Lane, Janet Roveda, Shu-Fen Wung, Ping Chang
Keywords(s):  
Category(s): Technology Classifications > Software & Information Technology, Technology Classifications > Software & Information Technology > Mobile Application
A Transformer-Based Diffusion Probabilistic Model for Vital Signs Forecasting
The model proposed in this technology, Transformer-based Diffusion Probabilistic Model for Sparse Time Series Forecasting (TDSTF), is a novel deep-learning algorithm that can be used for vital signs forecasting, data synthesis, simulation, and digital twins. Trained and tested on data from over 46,000 patients, the TDSTF technology merges transformer...
Published: 8/23/2024   |   Inventor(s): Ao Li, Ping Chang, Huayu Li, Janet Roveda
Keywords(s):  
Category(s): Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Software & Information Technology > Web & Internet
A Broad-spectrum Biopesticide Strain with Plant Growth Promoting Capability
The Challenge Plant diseases can wipe out entire crops and historical plantings in a short period of time as shown by boxwood blight. Globally, these diseases pose increasing risks to food security and plant biosecurity. Current approaches to disease management depend largely on chemical protection. These approaches are not sustainable due to growing...
Published: 1/24/2024   |   Inventor(s): Ping Kong
Keywords(s):  
Category(s): Technology Classifications > Agriculture, Technology Classifications > Environment/Green Tech
Novel Anti-HIV Compounds Using Peptides or Peptide Mimetics
Abstract: The subject invention describes a new class of compounds (such as peptides or mimetics) that target viral RNAs and inhibit the viral life cycle by blocking the viral recognition process. More specifically, these compounds are the first against an RNA Target - currently there are no clinical drugs against RNA targets in the treatment of any...
Published: 4/8/2024   |   Inventor(s): Yun-Xing Wang, Liu Yu, Ping Yu, Ina O'Carroll
Keywords(s): Anti-Viral, HIV
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease
Nucleic Acid Nanoparticles (NANP) and Methods of Using Same for Controlled Immunomodulation
Abstract: The technology is directed to compositions and methods of designing nucleic acid nanoparticles (NANPs) composed entirely of DNA, RNA, or DNA and RNA to achieve desirable immunostimulation and decrease undesirable effects on the immune system by changing the composition of the NANP. Benefits of the invention include the desirable activation...
Published: 4/8/2024   |   Inventor(s): Kirill Afonin, Justin Halman, Marina Dobrovolskaia, Enping Hong
Keywords(s): CANCER, Dobrovolskaia, IMMUNE, Immunomodulation, Inflammation, Nucleic Acid Nanoparticle
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Therapeutics
Chemically Modified AMPA Receptor RNA Aptamers Designed for In Vivo Use
" RNA aptamers as glutamate agonists offer potential therapeutics for a range of neurological disorders RSS.HDBackground> Background: < Neurological disorders are increasingly recognized as major causes of death and disability worldwide. Nearly 500,000 cases of brain tumor, multiple sclerosis, and amyotrophic lateral sclerosis (ALS) are...
Published: 1/22/2024   |   Inventor(s): Li Niu, Zhen Huang
Keywords(s): Technologies
Category(s): Technology Classifications > Screens and Assays, Technology Classifications > Research Tools and Reagents, Campus, Campus > University at Albany
Potent and Selective Inhibition of a Single AMPA Receptor Subunit by an RNA Aptamer
Inhibitors of AMPA type glutamate ion channels for the treatment of neurological disorders such as ALS, Alzheimer's, and Parkinson's. <.HDBackground>Background: Ionotropic glutamate receptors (iGluRs) play special roles in brain activities, such as memory and learning, and have been implicated in a variety of neurological diseases,...
Published: 1/29/2024   |   Inventor(s): Li Niu, Zhen Huang, Yan Han, Congzhou Wang, Jae Seon Park
Keywords(s): RNA, Technologies
Category(s): Technology Classifications > Biomedical Science and Engineering, Campus, Campus > University at Albany
Drug Candidate for ALS
RNA aptamers that focus on glutamate receptors are a potential drug candidate for amyotrophic lateral sclerosis (ALS). Background: Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, is a progressive neuromuscular disease for which there is no cure. The disease attacks motor neurons that run from the brain to the spinal cord...
Published: 1/29/2024   |   Inventor(s): Li Niu, Zhen Huang
Keywords(s): ALS, amyotrophic lateral sclerosis, aptamers, drug design, Lou Gehrig's disease, MND, motor neurone disease, RNA
Category(s): Technology Classifications > Biomedical Science and Engineering, Campus > University at Albany
Superstrong and Reversible Hydrogel Adhesives
Ultrastrong hydrogel adhesives that can carry greater than 50kgs of weight and yet can be rendered reversible. Problem: The current limit for the strength of reversible and reworkdable dry adhesives is in the range of 10-100 N/m2. This range is not enough to carry large weights greater than 50kgs. Solution: The current invention reports ultrastrong...
Published: 10/16/2023   |   Inventor(s): Shu Yang, Hyesung Cho, Gaoxiang Wu, Jason Christopher Jolly, Anand Jagota, Zhenping He
Keywords(s): Hydrogels, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials
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