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Diagnosis of hypertrophic cardiomyopathy and left ventricular hypertrophy using frequency domain analysis of ECG signals
Background Cardiac conditions involving abnormal thickening of the heart muscle, such as hypertrophic cardiomyopathy (HCM) and left ventricular hypertrophy (LVH), present significant diagnostic challenges due to their overlapping symptoms and similar manifestations in standard ECG readings. Existing diagnostic methods—including echocardiograms,...
Published: 5/19/2025   |   Inventor(s): Dongmei Chen, Edward Kim, Wei Li
Keywords(s):  
Category(s): Computer > Algorithms and software methods > Healthcare, Computer > Algorithms and software methods
Photoelastic Polymer Sensor
Executive Summary Sensors for measuring force or pressure are used in a wide variety of applications in industrial, healthcare and automation. Soft sensors, in particular, are used in applications where only low levels of stress are measured. However, one drawback with current soft sensors, is the long term repeatability and cost. Researchers at Michigan...
Published: 4/22/2025   |   Inventor(s): Jiabin Liu, Shaoting Lin, Wei Li
Keywords(s):  
Category(s): Advanced Materials, Devices, Test and Measurement
Hybrid Lighting Phosphors with High Quantum Efficiency, and Enhanced Thermal and Photostability
​ This rare-earth element-free invention can be used in LEDs to generate the entire visible spectrum​ Invention Summary: The use of rare earth elements in the phosphor coating of light-emitting diodes (LEDs) and compact fluorescent lamps (CFLs) raises environmental...
Published: 12/4/2024   |   Inventor(s): Jing Li, Yang Fang, Wei Liu
Keywords(s): LEDs, Photonics and photovoltaics
Category(s): Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Polymers/Composites/Materials, Technology Classifications > Electronics/Semiconductor
BASH-GN: A New Machine Learning–Derived Questionnaire for Screening Obstructive Sleep Apnea
BASH-GN is a machine learning-based questionnaire designed to classify the risk of obstructive sleep apnea (OSA) by considering various risk factor subtypes. Compared with other commonly used OSA screening tools, the BASH-GN questionnaire demonstrated superior performance, making it a more effective option for identifying at-risk individuals. This questionnaire...
Published: 9/23/2024   |   Inventor(s): Ao Li, Jiayan Huo, Stuart Quan, Janet Roveda
Keywords(s):  
Category(s): Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Healthcare Portfolios > Sleep Disorders
Improved Methods For Cryopreservation Of Cells, Tissues, And Organs
Summary: The National Eye Institute seeks research co-development partners and/or licensees for novel methods of cryopreserving cells, tissues, and organs via FOXO1 activation and other mechanisms. Description of Technology: The cornea is a critical part of the eye that helps prevent debris from entering and refracts light for proper vision. Corneal...
Published: 5/15/2025   |   Inventor(s): Jingxing Ou, Kiyoharu Miyagishima, Guanghui Jin, Wei Li, Lihao Ge
Keywords(s):  
Category(s): Application, Application > Research Materials, Collaboration Sought > Collaboration, TherapeuticArea > Ear, Nose, & Throat, Collaboration Sought > Licensing
A Transformer-Based Diffusion Probabilistic Model for Vital Signs Forecasting
The model proposed in this technology, Transformer-based Diffusion Probabilistic Model for Sparse Time Series Forecasting (TDSTF), is a novel deep-learning algorithm that can be used for vital signs forecasting, data synthesis, simulation, and digital twins. Trained and tested on data from over 46,000 patients, the TDSTF technology merges transformer...
Published: 2/26/2025   |   Inventor(s): Ao Li, Ping Chang, Huayu Li, Janet Roveda
Keywords(s):  
Category(s): Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Software & Information Technology > Web & Internet
MTS-LOF: Medical Time-Series Representation Learning via Occlusion-Invariant Features
Medical Time Series Representation Learning, known as MTS-LOF, uses the strengths of contrastive learning and Masked Autoencoder (MAE) methods, providing more sophisticated, context-rich representations, while also clarifying the interplay between temporal and structural dependencies in healthcare data. MTS-LOF is ideal for integration into numerous...
Published: 2/26/2025   |   Inventor(s): Ao Li, Huayu Li, Ana Carreon-Rascon
Keywords(s):  
Category(s): Technology Classifications > Software & Information Technology > Web & Internet, Technology Classifications > Software & Information Technology > Health IT
DeScoD-ECG: Deep Score-Based Diffusion Model for ECG Baseline Wander and Noise Removal
The DeScoD-ECG model is a novel electrocardiogram (ECG) baseline wander and noise removal technology that extends the current diffusion model for reconstructing electrocardiogram signals. It establishes a new benchmark in biomedical signal processing to provide a more accurate approximation of ECG signals for detection of cardiovascular irregularities....
Published: 1/17/2025   |   Inventor(s): Ao Li, Huayu Li, Gregory Ditzler, Janet Roveda
Keywords(s):  
Category(s): Technology Classifications > Software & Information Technology > Communications & Networking, Technology Classifications > Software & Information Technology > Open Source, Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Diagnostics
Biomimetic high-strength bone implant polymer material
Problem Bone defects are a global issue affecting millions, caused by factors such as trauma, aging, disease, surgical resections, and congenital abnormalities. There are natural and synthetic options for bone grafts or replacement. A natural bone graft may come from the patient or a donor and is surgically inserted and provides a surface for the remaining...
Published: 4/12/2024   |   Inventor(s): Wei Li, Hanyu Zhu, Vincent Wang
Keywords(s):  
Category(s): Life sciences > Biomaterials, Life sciences > Therapeutics > Synthetic biology
DNA Methylation Barriers
In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...
Published: 2/13/2025   |   Inventor(s): Li Liu, Jingmin Shu
Keywords(s):  
Category(s): Applied Technologies, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Diagnostic Assays/Devices
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