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Transgenic Mouse Model for Marfan Syndrome Research

Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...

Published: 12/23/2025 | Inventor(s): Li Li, Shichao Wu, Jiawei Zhao

Keywords(s):

Category(s): Technology Category > Research tools, Technology Category > Animal models, Technology Category > Biology, Technology Category > Diagnostic

Glanceability in Augmented Reality Systems

THE CHALLENGE Challenge in developing head-worn augmented reality (AR) devices lies in creating systems that can deliver timely, context-aware digital content without disrupting the user’s primary tasks. While there is strong market demand for hands-free, real-time information access—especially in sectors like manufacturing, healthcare,...

Published: 7/9/2025 | Inventor(s): Doug Bowman, Feiyu Lu, Wallace Santos Lages, Shakiba Davari-Najafabadi, Lorance Lisle, Yuan Li

Keywords(s):

Category(s): Technology Classifications > Consumer Products

SPACX- A silicon-based Photonic accelerator for DNN Chiplets architecture

The continuous increase in size and complexity of deep neural network (DNN) models leads to rapidly increasing demand for computing capacity which has outpaced the scaling capability of conventional monolithic chips. Chiplet-based DNN accelerators have emerged as a promising solution for continuous scaling. Nevertheless, the metallic-based interconnects...

Published: 1/9/2026 | Inventor(s): Yuan Li, Ahmed Louri

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Computers Electronics & Software, Technology Classifications > Computers Electronics & Software > Artificial Intelligence, Technology Classifications > Computers Electronics & Software > Processing Chips, Technology Classifications > Computers Electronics & Software > Computing Architecture

Sequential Targeting and Crosslinking Nanoparticles for Tackling the Multiple Barriers to Treat Brain Tumors

SUMMARYResearchers at the University of California, Davis have developed an approach to improve drug delivery to tumors and metastases in the brain. Their multi-barrier tackling delivery strategy has worked to efficiently impact brain tumor management while also achieving increased survival times in anti-cancer efficacy.BACKGROUNDWhile treating brain...

Published: 3/13/2023 | Inventor(s): Yuanpei Li, Hao Wu, Tzu-yin Lin

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Real-Time RT-PCR Assay for the Rapid Detection of Rabies and Other Lyssaviruses

Rabies occurs in more than 150 countries and territories, resulting in at least 55,000 human deaths per year worldwide according to World Health Organization estimates. Rabies is a vaccine-preventable viral disease caused by numerous lyssaviruses that are found in a variety of animal species throughout the world. Rabies virus infects the central nervous...

Published: 4/24/2025 | Inventor(s): Yu Li

Keywords(s): assay, DA4XXX, DDXXXX, Diagnostics, LYSSAVIRUSES, Modified, NCEZID, NCEZID-DHCPP, Non-rabies, Probe, rabies, REAL-TIME, RT-PCR, VLXXXX, VOXXXX, WBXXXX, WGXXXX, WHXXXX, WIXXXX, XEXXXX, YBXXXX, YGXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Occupational Safety and Health, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Therapeutics, Application > Research Materials, Application > Diagnostics

Universal Diagnostic Assay for Detection and Identification of Poxviruses in Clinical Samples

CDC researchers have developed an assay for detection and diagnosis of poxviruses within clinical samples or from lab culture-systems. The assay specifically targets chordopoxviruses (except avipoxviruses) for PCR-based identification; an improvement upon the current standard of cell culturing methodologies. Individual chordopoxvirus species can cause...

Published: 4/24/2025 | Inventor(s): Inger Damon, Hui Zhao, Yu Li

Keywords(s): ASSAYS, CDC Docket Import, CDC Docket Import CDC Prosecuting, CHORDOPOXVIRUSES, DA4BXX, DA4XXX, DAXXXX, diagnostic, DXXXXX, OID-NCEZID-DHCPP, VLXXXX, VOXXXX, WBXXXX, WFXXXX, WIXXXX, WMXXXX, XCXXXX, XEXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Occupational Safety and Health, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Diagnostics, Application > Research Materials

PKC412 restores functionality of the keratin cytoskeleton in the skin disorder epidermolysis bullosa simplex

Invention Summary: Epidermolysis bullosa simplex (EBS) is a highly penetrant genetic condition that causes fragility of skin keratinocytes resulting in fluid-filled skin blisters that erode upon scratching or minor pressure on the skin. There is no good cure for EBS, and treatment typically involves preventive and/or supportive care...

Published: 1/28/2026 | Inventor(s): Bishr Omary, Thomas Magin, Jacques Roberge, Katrin Rietscher, Pei Li

Keywords(s): Dermatology

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Rare Disease

Method for 3D Nonlinear Structured Illumination Super-resolution Imaging

Researchers at the University of Arizona have developed a super-resolution microscopy method that is faster, easier to use, and has less artifacts than current super-resolution methods. The result is a 3D dual-color stimulated emission depletion (STED) nonlinear structured illumination (NL-SIM) microscope. Using a combination of low coherent light and...

Published: 4/3/2023 | Inventor(s): Leilei Peng, Yu Li, Han Zhang

Keywords(s):

Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry

PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids

The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...

Published: 1/9/2026 | Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li

Keywords(s):

Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment

Chance-Constrained Optimization for Treatment of Prostate and Other Cancers in Intensity-Modulated Proton Therapy

The quality of IMPT treatment plans may be drastically diminished by uncertainties such as proton range and patient setup errors. If these uncertainties are not figured into treatment planning, the dose distribution that the patient receives may not be the same as the planned dose distribution. New treatment plans, which include optimized software/programming,...

Published: 7/4/2025 | Inventor(s): Jianming Liang, Yu An, Wei Liu

Keywords(s):

Category(s): Computing & Information Technology, Life Science (All LS Techs), Medical Imaging

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